Harlan肥胖模型高酯饲料 Diet induced obesity
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Harlan肥胖高酯模型
Diet induced obesity
 
Purified high fat diets used to induce obesity and obesity-related complications such as diabetes and metabolic syndrome typically have 40-60% of energy derived from fat. The diet tables below summarize relevant diet features for several Teklad custom research diets commonly used in rodent models.
Teklad also creates high-fat diets for other species, including pigs, primates, and dogs. Contact us to discuss the use of these diets or one that better meets your needs.

*Control diets can be designed in several ways, depending on what features the researcher wants to modify relative to the high-fat diet. These are just a few examples.

饮食诱导肥胖

用于诱导肥胖和肥胖相关并发症(如糖尿病和代谢综合征)的纯化高脂饮食通常有40-60%的能量来源于脂肪。下面的饮食表总结了一些特克拉德定制研究饮食的相关饮食特征，这些研究饮食通常用于啮齿类动物模型。
泰克乐还为其他物种，包括猪、灵长类动物和狗创造高脂肪饮食。联系我们讨论使用这些饮食或更好地满足您的需要。

*控制饮食可以通过几种方式来设计，这取决于研究人员相对于高脂肪饮食想要改变什么特征。这些只是几个例子。

Diets for diet-induced obesity (DIO)
Diets with 55-60% of calories from fat like TD.06414 and TD.93075 are commonly used for inducing obesity in rodents. While considered extreme compared to typical human fat consumption, these diets are effective in initiating rapid weight gain in most rodents. With higher fat content there is less room for carbohydrate, thus the carbohydrate (particularly sucrose) amount is relatively low compared to other obesity inducing diets. If you are interested in high fat and high carbohydrate, look at diets with 40-45% of calories from fat (often referred to as western diets).
As the fat level increases, pellet quality (durability) is often compromised. Some higher fat formulas are available only in non-pelleted form or require specific carbohydrate, maltodextrin, for pelleting. Depending on the fat and carbohydrate sources used, the non-pelleted form could be dense and crumbly, dough-like, or paste-like. Though a little more challenging to work with, non-pelleted diet is still used by many researchers for diet-induced obesity models as these researchers suspect the softer form may enhance obesity development.
Diets with 40-45% of calories from fat, like TD.95217, TD.88137, TD.06415, and TD.08811, represent another popular diet pattern for diet-induced obesity work. These diets have double or triple the amount of sucrose found in higher fat diets. High levels of simple carbohydrate like sucrose and fructose may help to promote hypertriglyceridemia, insulin resistance, and fatty liver. Diets with a pattern of high sucrose and high saturated or trans fat are often referred to as “Western Diets” in obesity and cardiovascular fields. Some “Western Diets” have further modifications to the fatty acid profile or even specific vitamin and minerals adjustments to be even more closely matched to a Western Diet pattern. For specific fatty acid modifications, see examples on our fat/lipid adjusted diets page.
Diets for diet-induced diabetes
Many of the same diets used for inducing obesity in rodents can be used to enhance diabetes related phenotypes like insulin resistance and glucose intolerance. However, fasting hyperglycemia characteristic of diabetes (glucose > 200 mg/dL) is uncommon with a diet only approach. Pre-feeding a high fat diet to induce a certain level of obesity and insulin resistance and then giving low-dose streptozotocin (STZ) may be an effective approach if overt hyperglycemia is desired.
Ingredient matched, low-fat DIO control diets
There are many options with different levels and types of fat in addition to different types of carbohydrate ranging from sucrose (highly refined, simple digestion) to corn starch (refined, but more complex) to resistant starch (refined, but not fully digestible). A very basic purified control diet would be AIN-93M (TD.94048) or AIN-93G (TD.94045). AIN-93 diets have a moderate amount of sucrose at ~10%, and fat is from soybean oil with a healthy fatty acid profile. Additional examples of controls for specific DIO diets can be found in the above tables.
Many researchers choose to compare their high fat fed animals to animals fed a natural ingredient, grain-based diet (also referred to as standard diets or chow). These diets differ in the source and level of nutrients as well as in the presence of non-nutritive factors (such as phytates or phytoestrogens). Depending on what your main comparisons are, it may be suitable to have a grain-based diet as your control/reference group. However, making such comparisons limits inferences to dietary patterns versus a specific dietary component.

Harlan TD.09682 高酯饲料 42% Fat Calories Diet (Western, Blue)说明书
货号：TD.09682
品牌：Harlan
英文名称：42% Fat Calories Diet (Western, Blue)
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Harlan TD.09682 高酯饲料 42% Fat Calories Diet (Western, Blue)说明书
Formula                            g/Kg
Casein                                195.0
DL-Methionine                       3.0
Sucrose                              341.46
Corn Starch                          150.0
Anhydrous Milkfat                      210.0
Cholesterol                            1.5
Cellulose                              49.85
Mineral Mix, AIN-76 (170915)            35.0
Calcium Carbonate                     4.0 +
Vitamin Mix, Teklad (40060)              10.0
Ethoxyquin,                            0.04
Blue Food Color                        0.15
Key Features
+ Purified Diet
+ Atherogenic
+ Modification of TD.88137
+ Color Coded
Key Planning Information
+ Products are made fresh to order
+Store product at 4°C or lower
+Use within 6 months (applicable to most diets)
+ Box labeled with product name, manufacturing date, and lot number
+ Replace diet at minimum once per week  More frequent replacement may be advised
+ Lead time:

• 2 weeks non-irradiated
• 4 weeks irradiated

Footnote
Modification of TD.88137 to add blue coloring.
Product Specific Information
+ 1/2″ Pellet or Powder (crumbly)
+ Minimum order 3 Kg
+ Irradiation available upon request
+ Vacuum packaging (1 and 2 Kg)

Harlan氨基酸调节饲料 Amino acid defined
品牌：Harlan
货号：TD.90262
英文名称：Amino acid defined
Harlan氨基酸调节饲料 Amino acid defined
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Amino acid defined | Harlan
A few amino acid defined formulas are shown below. This type of diet is used when a diet needs to be deficient in one or more amino acids, or adjustments need to be made to specific amino acid levels.
Formula examples:
TD.99366      Amino acid diet
TD.90262      Methionine and choline deficient diet
TD.00434      Folic acid deficient diet
TD.99386      No lysine AA diet
Sometimes this type of diet is used to further reduce the background level of certain vitamins that are found in protein sources such as casein or vitamin-free (alcohol extracted) casein. Some folic acid deficient diets utilize this approach.
The amino acid profile for most amino acid defined diets is based on work by Harper and Rogers (J. Nutr. (1965) 87:267-276) and is not representative of the amino acid profile of an intact protein source such as casein. Other amino acid profiles can be specified. When an amino acid(s) is removed or reduced, isonitrogenous adjustment can be made if required.
公式实例:
TD.99366氨基酸饮食
TD.90262蛋氨酸和胆碱缺乏饮食
TD.00434叶酸缺乏饮食
TD.99386不含赖氨酸AA饮食
有时，这种饮食被用来进一步降低某些维生素的背景水平，这些维生素存在于蛋白质来源，如酪蛋白或无维生素的酪蛋白(醇提取的)酪蛋白中。一些叶酸缺乏的饮食使用这种方法。
大多数氨基酸定义的饮食的氨基酸谱是基于哈珀和罗杰斯的工作(J.Nutr)。(1965)87：267-276)，不代表酪蛋白等完整蛋白质来源的氨基酸谱。还可以指定其他氨基酸谱。当氨基酸被去除或减少时，如果需要，可以进行等氮调节。
上海金畔生物科技有限公司（www.jinpanbio.com）提供生命科学研究领域系列产品，包括生化试剂、诊断试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料；修饰性PEG（Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG）；Sigma、Amresco、TCI、MP bio生化试剂；WAKO日本和光纯药、日本关东化学Kanto试剂、日本三菱、日本柴田科学SIBATA；Megazyme食品分析检测试剂盒、日本共立理化学；Research diets、Harlan饲料、Bio-Serv、日本CLEA Japan品牌的动物饲料；Oxoid、Nissui日水、日本荣研、BD difco、Himedia品牌微生物培养基；免疫诊断试剂包括:Bethyl抗体；Biolegend流式抗体、Abcam、CST、Santa Cruz抗体；Roche、TOYOBO、NEB品牌的酶；中检所、TRC、药典USP、EP、Reagecon标准品；耗材和仪器包括Whatman、日本Advantec滤膜、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Wheaton瓶子、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
上海金畔生物科技有限公司
服务热线:18301939375   QQ：3258089810    3259632176
Email:  info@jinpanbio.com
官网：http://www.jinpanbio.com

Harlan TD.95027低钙饲料(0.4%P)
Harlan货号：TD.95027
英文名称：Low Calcium Diet (0.4% P)
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Formula                                                                     g/Kg
Casein                                                                    200.0
Cystine                                                                     3.0
Sucrose                                                            342.188
Corn Starch                                                         320.0
Soybean Oil                                                          60.0
Cellulose                                                              40.0
Mineral Mix, Ca-P Deficient (79055)                    13.37
Potassium Phosphate, monobasic                     11.43
Vitamin Mix, Teklad (40060)                                10.0
Ethoxyquin, antioxidant                                       0.012
Key Features
+ Purified Diet
+ Calcium
+ Phosphorus
Key Planning Information
+ Products are made fresh to order
+Store product at 4°C or lower
+Use within 6 months (applicable to most diets)
+Box labeled with product name, manufacturing date, and lot number
+ Replace diet at minimum once per week More frequent replacement may be advised
+ Lead time:
· 2 weeks non-irradiated
· 4 weeks irradiated
上海金畔生物科技有限公司（www.jinpanbio.com）提供生命科学研究领域系列产品，包括生化试剂、诊断试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料；修饰性PEG（Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG）；Sigma、Amresco、TCI、MP bio生化试剂；WAKO日本和光纯药、日本关东化学Kanto试剂、日本三菱、日本柴田科学SIBATA；Megazyme食品分析检测试剂盒、日本共立理化学；Research diets、Harlan饲料、Bio-Serv、日本CLEA Japan品牌的动物饲料；Oxoid、Nissui日水、日本荣研、BD difco、Himedia品牌微生物培养基；免疫诊断试剂包括:Bethyl抗体；Biolegend流式抗体、Abcam、CST、Santa Cruz抗体；Roche、TOYOBO、NEB品牌的酶；中检所、TRC、药典USP、EP、Reagecon标准品；耗材和仪器包括Whatman、日本Advantec滤膜、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Wheaton瓶子、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
上海金畔生物科技有限公司
服务热线:18301939375   QQ：3258089810    3259632176
Email:  info@jinpanbio.com
官网：http://www.jinpanbio.com