日本EIKEN荣研化学株式会社微生物培养基

日本EIKEN荣研化学株式会社微生物培养基
上海金畔生物代理日本EIKEN荣研化学株式会社微生物培养基培养基系列产品,欢迎新老客户访问日本EIKEN荣研化学株式会社官网或者咨询我们获取跟到有关产品信息。

EIKEN CHEMICAL manufactures and markets a range of products used in the field of microbiology.  荣研化学株式会公司生产和销售一系列用于微生物学领域的产品。


 
 
 
 

Culture Media

In 1949, EIKEN successfully commercialized the manufacture of the first dehydrated powdered agar in Japan. Since then,
we have been committed to bring out high-quality products for various bacteriological exams.
Pearlcore series
Pearlcore series are granulated media developed for more convenient use. Pearlcore allows quick dissolution and easy measurement while keeping good quality that our dehydrated powdered media have developed.
We own the dedicated plant called DCMP for production of dehydrated culture media. DCMP allows
us high productivity and continuous quality improvement to meet customers’ satisfaction.

Major Products

Code No.

Product Name

Usage

E-MJ00 Agar`Eiken’ Preparation for solid/semisolid medium
E-MD03 TCBS Agar `Eiken’ Isolation of cholera vibrios / vibrio para
E-MB31 BCP Plate Count Agar `Eiken’ Enumeration of Lactobasilli in dairy products
E-MF21 Potato Dextrose Agar `Eiken’ Isolation, preservation and identification of fungi
E-MA32 SIM Medium `Eiken’ Differentiation of the intestinal bacteria on the basis of sulfide production, idole formation, motility, and IPA reaction.

Only available in Japanese-package. English product information will be provided for instruction for use.

文化媒体

1949年,EIKEN在日本成功地将第一批脱水粉末琼脂的生产商业化。从那以后,我们一直致力于为各种细菌检验生产高质量的产品.
Pearlcore级数
Pearlcore系列是为方便使用而开发的造粒介质。Pearlcore允许快速溶解和易于测量,同时保持我们的脱水粉状介质的良好质量。
我们拥有一家名为DCMP的生产脱水培养基的专用工厂。DCMP允许我们生产效率高,质量不断提高,以满足客户的满意。

主要产品

代码号。

产品名称

使用

E-MJ 00 艾肯 固体/半固态介质的制备
E-MD 03 TCBS琼脂‘eiken’ 霍乱隔离弧菌 /弧菌第2段
E-MB 31 BCP平板计数琼脂‘eiken’ 计数拉克托巴西里乳制品
E-MF 21 马铃薯Dextrose琼脂‘eiken’ 分离、保存和鉴定真菌
E-MA32 SIM介质“eiken” 根据硫化物的产生、咪唑的形成、运动和IPA反应来区分肠道细菌。

栄研化学株式会社

  •  TCBS琼脂培养基
    35℃,24hr
  •  加蛋黄甘露醇食盐琼脂培养基
    35℃,48hr
  •  EC肉汤培养基
    44.5℃,24hr
  •  煌绿乳糖胆盐肉汤培养基
    35℃,24hr
  •  ES Coliblue Medium(紫外线下(365nm))
    35℃,24hr
  •  ES Coliblue Medium
    35℃,24hr
  •  ES Colimark Aguar
    混释平板培养法 35℃,20hr
  • ES大肠杆菌琼脂培养基
    混释平板培养法 35℃,20hr
  • 伊红美蓝琼脂培养基
    35℃,24hr
  •  去氧胆酸琼脂
    混释平板培养法 35℃,20hr
  • 马铃薯琼脂培养基
    涂抹平板培养法 25℃,72hr
  •  标准寒天培养基
    混释平板培养法 35℃,48hr

日本老化JaICA中国代理及JaICA品牌介绍

日本老化JaICA中国代理及JaICA品牌介绍

Japan Institute for the Control of Aging (JaICA)

上海金畔生物作为日本 JaICA 老化中国代理商,欢迎新老客户访问日本 JaICA 老化官网或者咨询我们获取更多日本 JaICA 老化产品线价格说明书等信息。
日本老化制御研究所 Jaica代理

日本老化制御研究所自成立以来就对抗衰老进行研究,它是在有助于健康促进的理念下创建的。结果,此研究所在开发DNA氧化损伤测试试剂盒方面取得了很大的成功,并在该领域处于了领先地位。
本研究所现在销售许多氧化应激相关产品,这些产品可应用于医学,药学,生化学,食品科学等。它还利用其独特的技术开展检测服务。随着社会老龄化的发展,预防医学与抗衰老引起了越来越多的关注,在这些领域中,我们研究所将会通过开发和提供研究产品来助于营造一个健康,长寿的社会。
产品类型:
1. DNA氧化检测产品;
2. 蛋白氧化检测产品;
3. 脂肪氧化检测产品;
4. 抗氧化检测产品。
特性:
1. 高专一性、高灵敏性;
2. 不与RNA损伤产生交叉反应;
3. 易于操作、简单快速;
4. 无需昂贵的设备和样品预处理。

日本Jaica
The Japan Institute for the Control of Aging has conducted research into control of aging since its foundation under the doctrine of contributing health promotion. As a result, the institute succeeded in developing a DNA oxidative damage measuring kit, thus taking the lead for this field.
The institute now sells many products related to oxidative stress, and such products are utilized in the fields of medicine, pharmacy, biochemistry, food sciences, etc. The institute also performs assay services utilizing its unique technologies. Preventive medicine and anti-aging are receiving increased attention with the advancement of aging society. In these areas, our Institute will contribute to realizing a healthy, long-lived society by developing and supplying research products.

独特的氧化应激标记物

日本控制衰老研究所从事衰老研究,目的是促进人类健康。该研究所成功研发了检测DNA氧化损伤的试剂盒,并且在这个领域处于领先地位。该研究所目前销售很多关于氧化应激研究方面的产品。这些产品在医学,药学,生物化学和食品方面都有运用。该研究所也提供定制服务。随着步入老龄化社会,预防医学和抗衰老收到越来越多的关注。
JaICA从事试剂盒销售和定制服务。试剂盒部分,研究所研发和生产用于检测氧化应激标记物的试剂盒。单抗和ELISA试剂盒可用于检测活性氧产生的氧化损伤产物。定制服务部分,使用本研究所研发的产品和积累的经验检测尿液和血液样品,检测食品。近来预防医学、抗衰老和功能性食品的关注越来越多,因此全球医院,大学,研究所、食品企业和制药企业分析氧化应激标记物,衰老相关激素和矿物质需求也越来越多。
◆氧化应激标记物概况

类型 产品名称 运用 备注
尿液 血清 组织
DNA 氧化 8-OHdG   Check ELISA Kit 是(动物) 普遍使用的氧化应激标记物
检测时间:大概3.5小时
8-OHdG   Check ELISA Kit (High Sensitivity) 是(动物) 人血清、组织和培养细胞的更低检测限。
anti-8-Hydroxy-2′-deoxyguanisine   [8-OHdG],mAb(N45.1) 8-OHGua/8-OHG低交叉反应性
anti-Thymidine   Glycol [TG], mAb (2E8) DNA特异性氧化应激标记物
脂类氧化 Hexanoyl-Lys   [HEL] ELISA Kit n:6 多不饱和脂肪酸早期氧化的新标记物
anti-Hexanoyl-Lys   [HEL], mAb (5F12) 免疫组化,免疫印迹和ELISA
anti-Hydroxy-2-nonenal   [4-HNE], mAb(HNEJ-2) 普遍使用的脂类氧化标志物
anti-Acrolein   [ACR], mAb (5F6) 免疫组化, 免疫印迹 和 ELISA.
anti-Malondialdehyde   [MDA], mAb (1F83) 免疫组化 和 免疫印迹
anti-4-Hydroxy-2-hexenal   [4-HHE], mAb (HHE53) 免疫组化
anti-Crotonaldehyde   [CRA], mAb (82D3) 免疫组化
anti-Methylglyoxal   [MG], mAb (3C) 免疫组化
anti-7-Ketocholesterol   [7-KC], mAb (35A) 胆固醇氧化标记物
蛋白氧化 Dityrosine   [DT] ELISA Kit 蛋白氧化新型标记物。检测时间:过夜 + 1.5小时。
anti-Dityrosine   [DT], mAb (1C3) 免疫组化, 免疫印迹 和 ELISA.
anti-Dibromo-tyrosine   [DiBrY], mAb (3A5) 炎症相关的蛋白氧化标记物
抗氧化检测 Total   Antioxidant Capacity [PAO] Test Kit Food
Samples
血清、食物和酒水总抗氧化检测,能够疏水和亲水的抗氧化剂。

日本FUCHIGAMI 动物毛发记号笔

日本FUCHIGAMI 动物毛发记号笔
上海金畔生物代理日本FUCHIGAMI品牌产品,欢迎新老客户访问日本FUCHIGAMI官网或者咨询我们获取更多相关产品信息
日本FUCHIGAMI 动物毛发记号笔
中文名称:动物安全标记笔(记号笔)
英文名称:Animal Marker
国产/进口:日本进口
产地/品牌:日本 Fuchigami
产品类别:动物器具
规       格:中号(AM15),小号(AM10)
我们使用由肯辛顿公司开发并由卫生和福利部条例规定的合法色素。
它是严格管制的产品,如质量标准和测试方法。
该品牌实验动物专用毛发标记笔,能够方便快捷的为动物区分标识度,采用专业染料无毒无害,深受业内人士的肯定。
该产品由染发剂制造商开发,它是一种安全性极佳的动物标记物。
■■■功能■■■
它是一种可以放心使用的标记。
我们有5种方便的颜色(蓝色/绿色/红色/黄色/橙色)。
它对动物的皮肤和体毛具有很强的穿透力,即使动物舔它也不会脱落。
这取决于动物的大小,但它可以处理大鼠使用的约400至600只动物。
它不会在长期研究期间褪色,并且通常会在6到12周内保持良好的辨别能力。
■■■特点■■■
1,可简便并放心使用的标记笔,使用日本厚生省法定色素。
2,配备了5种高识别度色彩(蓝,绿,红,黄,橙)
3,对动物皮肤、体毛的渗透力较强,即便被舔舐也不易掉色。
4,一支标记笔用于实验动物老鼠上大致可处理400-600只。
5,绝对保证长期试验过程中不褪色,在一般条件下可保持6-12周的良好辩识度。

アニマル・マーカー
アニマル・マーカー
規格表
規格表
法定色素使用
动物安全标记笔:
中号(AM15)

CatNo.
绿
容量
15 ml
包装数量
1盒:10支装 (各2支 / 色)
小号(AM10)

CatNo.
绿
容量
10 ml
包装数量
1盒:10支装 (各2支 / 色)

日本FUCHIGAMI 小鼠灌胃针(PTFE软管)

日本FUCHIGAMI 小鼠灌胃针(PTFE软管)
上海金畔生物代理日本FUCHIGAMI品牌产品,欢迎新老客户访问日本FUCHIGAMI官网或者咨询我们获取更多相关产品信息
该产品比较适合老鼠、豚鼠等等
对小型实验动物的强制经口用药没有发生问题吗?
近年来,在GLP(有关实施医药品安全性试验的标准)中,有人指出了保证动物实验数据的可靠性的恰当方法和程序。把一根经口探针洗净再利用,多用途使用,从质量保证方面来讲是不可取的。
另外,给实验动物带来痛苦、压力,造成肺、气管的误用以及邻近各脏器的损伤等问题也发生了。
因此,本公司开发出了能够获得对实验动物温柔、可靠的实验数据的一次性经口探针.特别是在柔性型细管中,采用耐药品性、柔韧性、低摩擦性、非粘合性的PTFE管,容易渗透粘度高的液体。开发出了可以任意弯曲加工,即使弯曲也不易弯曲的商品.
结果减轻了肺、气管误服及损伤邻近各脏器的麻烦,使获得更准确的实验数据成为可能.现在,除了1986年发售的不锈钢类型外,还发售了挠性型、防挠嚼型。
这些商品出于质量维持的目的,在制造过程中设置了手工工序,每件一一精心制造,现在来自国内外※的许多研究所·实验中心等客户,得到录取,深受好评(美国、加拿大、英国、瑞典、挪威、韩国等
本产品不需清洗、灭菌,方便、安全,价格比其他厂家产品价格低,价格低廉。
我确信,我们一定会为您效劳的.

ステンレスタイプ

PTFE管的特征

各方面都比PP、PE管材高出几倍。
耐药品性 对化学药品表现出良好的抵抗,不浸泡在任何酸、碱、有机药品中.
柔软性 可以任意弯曲加工,弯曲也不用担心折断。
低的摩擦性 不损伤物体滑滑、敏感的临近各脏器.
配合非粘合性,容易投入高粘度的液体.
过错粘着性 具有弹奏液体的特性,不剩液态.
※化工厂·半导体制造装置·食品制造装置·理化学设备等被广泛用于工业领域。

硅橡胶的特征

无味、无臭、无毒,不被其他物质浸泡在化学上也稳定,在食品、医疗、理化方面使用。

PTFE特性比较表

非常优越0=优越=稍差×=较差
树脂特性 PTFE FEP ETFE PFA PCTFE PVDF 六尼龙 聚丙烯
硬质聚乙烯
氯乙烯
耐热性
(常用温度°C)
260 200 150 260 150 150 80-120 100到120 60
电的特性
阻燃性(0.1%) 95< 95< 30 95< 95 43 24 18 45
机械的特性
低的摩擦性
耐药
品质
×
碱性 ×
溶剂 ×
过错粘结性 × ×
耐候性 × × ×
透明性
成形性
比重 2.17 2.15 1.73 2.15 2.13 1.76 1.13 0.9 1.35
来自Pakkinland HP株式会社的引用

不锈钢类型

特征 ■■■

  • 是没有残留药物的麻烦,安心使用的一次性(一次性)产品.
  • 管子因为不锈钢细管能简单地弯曲加工,所以初学者也能很容易地投入.
  • 前端是球状硅,具有弹性,能够顺利地向食道投药,因此可以减轻肺、气管的误用和对邻近各脏器的损伤。
  • 为了应对多种小型实验动物,我们准备了各种尺寸.
  • 5支小份包装·EOG灭菌(公共机关)的无菌及急性毒性试验中被安全确认),仅能使用必要的数量,不费清洗、灭菌的工夫。
4200系列    (单位:mm)
Cat No. 规格 针长 先玉 外径×内径 销售单位
4202 用鼠标 38 1.9 0.92×0.62 一盒:
一百根装×五箱
(500个)
4204 用老鼠 52 2.3 1.20×0.83
4206 老鼠和豚鼠用 78 2.9 1.81×1.45

也有未灭菌的商品

【 针基色
針基色

(4202)
針基色

(4204)
針基色

(4206)
6200系列    (单位:mm)
Cat No. 规格 针长 先玉 外径×内径 销售单位
6202 用鼠标 70 1.9 0.92×0.62 一箱:500个装
6204 用老鼠 80 2.3 1.20×0.83
6206 老鼠和豚鼠用 95 2.9 1.81×1.45 一盒:
250根装×2箱
(500个)
也有未灭菌的商品

【 针基色
針基色

(4202)
針基色

(4204)
針基色

(4206)

柔性类型耐药品性、柔软性、低摩擦性、非粘着性优异
用PTFE管,消除给药时的故障.
特征 ■■■
口径的材质是灵活的PTFE,尖端采用柔软的球状硅。
软管具有可以任意弯曲加工的特性,所以可以防止对肺、气管的误用。
另外,由于优异的低摩擦性,可以无抵抗地顺利地插入食道,减轻损伤敏感的临近各脏器的纠纷。
软管结合了非粘着性、低摩擦性,容易投入粘度高的液体,不残留液体.
管状物是半透明的,容易确认试验药物.
为了应对多种小型实验动物,我们准备了各种尺寸.
5支小份包装·EOG灭菌(公共机关)※的无菌及急性毒性试验中被安全确认),仅能使用必要的数量,不费清洗、灭菌的工夫。

フレキシブルタイプ
フレキシブルタイプ
5200系列   (单位:mm)
Cat No. 规格 针长 先玉 外径×内径 销售单位
NEW 5200S 用鼠标 30 1.9 0.90×0.50  
1箱:250根装
(1包5个)
×50包)
 NEW  5200 38
NEW 5202SS 25 2 1.18×0.68
NEW 5202S 30
5202 38
5204 用老鼠 52 2.4 1.46×0.86
5206 78 2.8 1.79×1.19
也有未灭菌的商品    5200S·5200使用PFA

【 针基色
針基色

(5200S、5200)
針基色

(5202SS、5202S、5202)
針基色

(5204)
針基色

(5206)
7200系列   (单位:mm)
Cat No. 规格 针长 先玉 外径×内径 销售单位
7202 用鼠标 50 2 1.18×0.68 1箱:250根装
(1包5根×
50包)
7204 用老鼠 75
7206 85 2.4 1.46×0.86
7208 100 2.8 1.79×1.19
7210 老鼠和豚鼠用 110 2.9 2.10×1.50 1箱:200根装
(1包5根×
40包)
120
也有未灭菌的商品

【 针基色
針基色

(7202、7204)
針基色

(7206)
針基色

(7208)
針基色

(7210、7212)

柔性啮合防止类型
特征 ■■■
连接有弹性的硅头球和PTFE管,针基附近的管部分是被不锈钢管覆盖的商品.
试验药物投药时,可以最大限度的防止实验动物咬断软管。
不锈钢管具有适度的弹性和强度,无需担心误用肺、气管或损伤邻近各脏器,为了得到正确的实验数据,受到很多研究者的关注。
材质采用从耐药品性、低摩擦性等各个方面使与试验药物的相互作用最小的物质。
为了应对多种小型实验动物,我们准备了各种尺寸.
通过每5个小口包装·EOG灭菌(公共机关※的无菌及急性毒性试验被安全确认),只能使用必要的数量,不需要清洗、灭菌。

フレキシブル噛切り防止タイプ
5200/7200系列  (单位:mm)
Cat No. 规格 针长 先玉 外径×内径 防止咬伤
管长
销售单位
5202K 用鼠标 38 2 1.18×0.68 11 1箱:250根装
(1包5个)
×50包)
5204K 用老鼠 52 2.4 1.46×0.86 13
5206K 78 2.8 1.79×1.19 15
7202K 用鼠标 50 2 1.18×0.68 11
7204K 用老鼠 75
7206K 85 2.4 1.46×0.86 13
7208K 100 2.8 1.79×1.19 15
【 针基色
針基色

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針基色

(5206、7206K)
針基色

(5206K、7208K)

Torpac动物投药用胶囊使用说明书

Torpac动物投药用胶囊说明书
Torpac公司的实验动物专用投药胶囊是猪皮为原料制成。颗粒、粉末、混合液体等无论哪种形态的被验药物都可以被完全有效地投放到动物胃部。
使原先不可能的操作变得简单精准。另外还有投药器和灌药底座的成套产品出售。
动物给药胶囊,非常适合对大鼠、小鼠进行胶囊式口部给药。
先对药物进行胶囊灌装,再对大鼠或小鼠进行给药操作。
灌入胶囊内的被验药物没有形状的限制。除粉末、颗粒、锭剂等固体之外,还有糊状、悬浊液等,都可以被填充。
与经口灌胃针相比,无需插入,投药简单方便。
刺激性强的溶媒或是被验药做成了胶囊,可以在胃里充分吸收,不会呕吐。
即使被验药有臭味或是苦味,也不会对动物造成应激影响,让动物在放松自然的状态下服用药物。
也不会产生混在饲料中喂食的剩下残留药物的情况,能准确计算投药量

Now Available: bovine-free gelatin capsules in veterinary sizes.
Capsules offer several advantages:

bullet Faster product introductions.
bullet Capability to deliver unique products.
bullet More profitable smaller runs.
bullet Higher product memorability.

对大鼠、小鼠、豚鼠进行胶囊给药:
粉末或者固体的药物,或者无法用导管进行投药的情况下,使用胶囊就可以轻松投药;
对应一些有臭味或者苦味的药剂,能够简单投药,减轻动物的痛苦;
个别制剂类药物的投药相当便利;
为了能够长时间持续的发挥药效,胶囊可以辅助充分吸收;
实验规程中必须要用胶囊进行投药的情况下,是最适合的;
与药物混在饲料中进行喂食相比,用胶囊的方法准且无残留;

1. Separate a single capsule. Place the capsule body (Longer, narrower part of the Capsule) in the holder.   打开胶囊,将胶囊体放在不锈钢底座内。
2. Place the funnel over the capsule body in the holder.    放上漏斗。
3. Dose a pre-measured amount of powder into the capsule through the funnel, or put the assembly on a precision balance, tare it, and dose the powder into the capsule through the funnel.
将事先准备好的药物粉末通过漏斗填充到胶囊内,或者将该装置放到天平上,边称边向漏斗内加入药物。
4. When the required quantity of powder has been put into the funnel, use the tamper to compress filling material into capsule body.   用不锈钢棒挤压药物粉末。
5. Slowly remove the funnel.   移开漏斗
6. Place the capsule’s cap onto the body of the capsule, pressing firmly to lock. Remove the filled capsule from the base.     盖上胶囊盖子,从不锈钢孔底座内取出。
犬用(NO.11、12、13)大鼠及豚鼠用(NO.9)

胶囊尺寸 Size 9 Capsule Size 9el Capsule
填充容量 0.025ml 0.08ml
填充重量 25mg* 80mg*
长度(密闭时) 8.6mm 23.2mm
最大外径 2.65mm 2.65mm
动物体重 大鼠 200g 以上
豚鼠 300g 以上
大鼠 200g 以上
豚鼠 300g 以上

*:填充物密度为1g/ml时。

 Parameter Size 9el Size 9 Size 9h Size M
 Species & Weight Rats 200g+ Rats 200g
(min 150g)
Guinea Pig 300g+
Hamsters & Rats 150g+ Mice 25g+
 Species & Weight Lower GI Delivery n/a Rat 200g+
Guinea Pig 300g+
Hamster
& Rat 150g+
Guinea Pig 300g+
Mice 30g+
 Capsule Body Capacity 0.08 ml 0.025 ml 0.013ml 0.004 ml
 Fill Weight (materials with density 1g/ml) 80 mg 25 mg 13mg 4 mg
 External Diameter Maximum 2.71 mm 2.71 mm 2.71 mm 1.27 mm
 Length When Locked Maximum 23.0 mm 8.4 mm 5.1mm 8.4 mm
 Surface area locked capsule in sq mm for enteric coating. Not Applicable 68mm2 42 mm2 31mm2
 Weight Empty (Cap & Body) Average1 17 mg 10 mg 5mg ~2 mg
 Colors Available Clear & Opaque Clear & Opaque Clear & Opaque White
For a specific net fill weight tare the weight of each capsule body individually and then fill or use a pre-weighed amount of powder for each capsule.

Tip: Order syringes for each technician to speed dosing.

Torpac动物投药用胶囊

Torpac动物投药用胶囊
Torpac是专业是动物给药用品提供商,从小鼠到牛各种大小动物胶囊制作设备及耗材提供商
世界领袖:
torpac是定制胶囊(可溶性容器)的全球领dao者,也是台式胶囊填料市场的先驱。它的产品在北美,欧洲和环太平洋国家使用。
重要产品:
torpac的胶囊和机器主要用于包装动物和人类药物和营养产品。它们还被用于开发救命药物。
独特客户:
我们的客户主要在制药行业,包括拜耳,礼来,默克,诺华,辉瑞,Shionogi等主要制药公司; 独立制造商; 以及研究实验室,例如Agouron,Idex和Sepracor。在制药行业之外,我们的客户包括美泰玩具,派拉蒙影业,劳斯莱斯和西部数据。
新应用:
torpac为客户开发胶囊和新型药物应用的zhuan利用途提供支持:胶囊封装,导线形式的氧化铜和鼻腔手术中使用的胶囊。torpac专注于非药用胶囊,并帮助其客户在其他产品中引入玩具,实验室测试包和光学元件包装。
历史:
Torpac成立于1989年,年增长率稳定在两位数。它在美国新泽西州费尔菲尔德设有销售和分销中心,并在印度孟买以外的ISO-9002工厂生产。
给药试剂盒包括开始给予啮齿动物所需的一切。
套件包括:(1)给药注射器,(2)填充漏斗和支架
实验用投药胶囊

装药器、投药器套装 
Dosing Kits include capsules, funnel, stand, tamper, dosing device & instructional video

非常适用于不溶物,形成不良悬浮液,受异常影响,或有异味和令人反感的物质(如持续释放珠粒,油漆片,氧化铬标记)
通过消除悬架/溶液均匀性的验证来节省时间和金钱。
消除异常吸收效应。
用于豚鼠的低GI传递。

TORPAC公司出品 大鼠・豚鼠投药用胶囊

 

各种各样的被验药物需要经口投药的情况下,使用胶囊会比其他方法来的更为合适与便利。

  • 粉末或者固体的药物,或者无法用导管进行投药的情况下,使用胶囊就可以轻松投药。
  • 对应一些有臭味或者苦味的药剂,能够简单投药,减轻动物的痛苦。
  • 个别制剂类药物的投药相当便利。
  • 为了能够长时间持续的发挥药效,胶囊可以辅助充分吸收。
  • 实验规程中必须要用胶囊进行投药的情况下,是最适合的。
  • 与药物混在饲料中进行喂食相比,用胶囊的方法更精准且无残留。

灌入胶囊内的被验药物没有形状的限制。除粉末、颗粒、锭剂等固体之外,还有糊状、悬浊液等,都可以被填充。
与经口灌胃针相比,无需插入,投药简单方便。
刺激性强的溶媒或是被验药做成了胶囊,可以在胃里充分吸收,不会呕吐。
即使被验药有臭味或是苦味,也不会对动物造成应激影响,让动物在放松自然的状态下服用药物。
也不会产生混在饲料中喂食的剩下残留药物的情况,能准确计算投药量
Torpac动物投药用胶囊特点:

填充材料 填充重量和准确度 给药时间和验收
  • 任何形式的干燥材料(粉末,珠粒,水晶,油漆片),糊状物和非水液体。
  • 25毫克。每个胶囊用于密度为1g / ml的材料。
  • <1分钟 (60只大鼠30-45分钟)
  • 在最小经验后成功给药> 98%(每只大鼠3-4剂安慰剂)
解体时间 动物重量 降低胃肠道药物传递
  • 在啮齿动物的胃里10分钟内。
  • 大鼠:200克+(分钟。150克)
  • 豚鼠:300克+
  • 适用于豚鼠下胃肠道的肠溶包衣和药物递送。

胶囊尺寸 Size 9 Capsule Size 9el Capsule
填充容量 0.025ml 0.08ml
填充重量 25mg* 80mg*
长度(密闭时) 8.6mm 23.2mm
最大外径 2.65mm 2.65mm
动物体重 大鼠 200g 以上
豚鼠 300g 以上
大鼠 200g 以上
豚鼠 300g 以上

*:填充物密度为1g/ml时。

Parameter Size 9el Size 9 Size 9h Size M
 Species & Weight Rats 200g+ Rats 200g
(min 150g)
Guinea Pig 300g+
Hamsters & Rats 150g+ Mice 25g+
 Species & Weight Lower GI Delivery n/a Rat 200g+
Guinea Pig 300g+
Hamster
& Rat 150g+
Guinea Pig 300g+
Mice 30g+
 Capsule Body Capacity 0.08 ml 0.025 ml 0.013ml 0.004 ml
 Fill Weight (materials with density 1g/ml) 80 mg 25 mg 13mg 4 mg
 External Diameter Maximum 2.71 mm 2.71 mm 2.71 mm 1.27 mm
 Length When Locked Maximum 23.0 mm 8.4 mm 5.1mm 8.4 mm
 Surface area locked capsule in sq mm for enteric coating. Not Applicable 68mm2 42 mm2 31mm2
 Weight Empty (Cap & Body) Average1 17 mg 10 mg 5mg ~2 mg
 Colors Available Clear & Opaque Clear & Opaque Clear & Opaque White
For a specific net fill weight tare the weight of each capsule body individually and then fill or use a pre-weighed amount of powder for each capsule.

Tip: Order syringes for each technician to speed dosing.

Torpac公司动物给药胶囊

Torpac公司动物给药胶囊
上海金畔生物代理美国Torpac公司产品,欢迎客户访问Torpac官网或者咨询我们获取更多Torpac公司的动物给药胶囊等相关产品信息。
Torpac—专业供应各型胶囊及胶囊灌装机
Torpac成立于1989年,是定制化可溶性胶囊的世界领军企业,也是桌面胶囊灌装机市场的先驱。它的产品胶囊壳、空心胶囊、给药器和胶囊灌装机主要用于人及动物药品(从小鼠到牛各种大小动物)和营养品的包装和给药,以及长保质期药物的研发。公司产品被世界各大只要企业所采用,包括拜耳、礼来、默克、诺华、辉瑞、盐野义及其它制药厂、研发中心(如Agouron、Idex及Sepracor)。除了只要企业,Torpac还为美泰玩具、 派拉蒙电影公司、劳斯莱斯和西部数据提供产品服务。
Torpac可支持客户研发胶囊及新药应用的新型,如囊中囊、线型氧化铜及鼻外科用胶囊。Torpac还擅长非药用容器产品生产与研发,可帮助客户研发小型的实验室测试系统及封装光学元件。

Torpac公司主要产品介绍:
一、胶囊产品系列
该系列产品包括常规各种粒径的无牛来源成分的明胶胶囊,兽医辅助配/用药胶囊及给药试剂盒系统三个子系列产品。
1、各种粒径的常规胶囊产品,除型号规格齐全,安全可靠外,Torpac公司的该系列明胶胶囊还具有以下优势:
Ø可使药物研发和生产具有更高的灵活性,因此带来更大的利润。
Ø适用于各种大小动物的给药,包括肉牛、奶牛、绵羊、山羊、鹿、马、狗和猪。
Ø 可内填各种性质的材料,如固体、液体、面团装以及组合型材料,胶囊在体内几分钟内即可溶解。
Ø 给药形式可以是口服、经阴道和产后子宫内给药,该系列胶囊可溶解于饮用水中。
Ø 给药快、高兼容性、高利润等。

2、兽医辅助配/用药胶囊产品系列
采用该系列产品,可剂量准确地给各种类型的材料,包括固体(粉末、颗粒、小圆粒等)、液体和面团状材质的材料。明胶胶囊无味(可隐藏药物本身难闻的气味和味道),可在胃(包括瘤胃)、阴道和子宫中快速完全溶解,对有机体本身无副作用。该系列产品还具有以下优势:
Ø可确保动物获取足量剂量的药物。
Ø 可在移出滞留胎盘后实现子宫内给药。
Ø可体内定量给驱虫药、大分子前体物质、酶及酵母等。
Ø 可采用常规投丸器同时给几种小胶囊和药片。

 
3、给药试剂盒系统
该系统包括胶囊、漏斗、支架、给药装置及使用操作视频。该系统是难溶性、悬浮材料的理想给药选择,不受赋形剂影响,可极好地隐藏药物难受的气味和味道。适用于缓释颗粒、漆片及标记的氧化铬等给药使用。

4、临床前研究用胶囊产品系列
该产品系列可用于临床前研究,胶囊型号包括11, 12, 13, 9 & 9el号。

 
二、非药用产品
除药用胶囊外,Torpac公司还供应多种非药用明胶产品,用于玩具、医疗器械、光学材料及影视行业。
1、玩具行业:
因胶囊具有独特的水溶性、生物可降解、无毒的天然蛋白特性,因此可安全用于玩具行业,用于填充各种形式的材料,如粉末、海绵泡沫等。外观可呈现不透明的珍珠色及闪亮色,或者透明的一致性颜色如粉色等,对环境温度适应性高(可耐-268° C低温及30° C以下室温)

 
2、医疗器械领域使用
因胶囊具有生物可溶解、无害的特点,临床上可用于吞咽及插入辅助器具使用。此外,Torpac公司的胶囊产品还可实现创新性使用:常规粒径和形状的胶囊可用于封装小型测量设备,服用后在胃里胶囊溶解后释放出测量设备,此外,该设备还可与胶囊外以连接线连接方便测量后取出;定制大小的胶囊可用于封装脱矿的骨或其它化合物用于整形外科;定制形状的胶囊可用于包被用于通过一个小创口插入体内的管子或其他相关设备的末端,以提供一个平滑、润滑的表面而便于管子或设备到达预定位置,而包被的末端在5-10分钟左右胶囊融化后即可暴露便于操作。
3、用于光学材料包被及其它材料保存
由于胶囊材料特殊的生物特性,可用于透镜、镜头、滤光器、晶体等微光学及电子材料的封装和保存,既安全可靠,保护平滑表面,又能与空气隔绝,而且操作方便快捷。

三、胶囊生产相关设备
该系列产品可满足多种规格和型号胶囊的生产,相关设备有
1、常规胶囊生产设备(适用于0-5号及el号胶囊生产)
2、大型胶囊生产设备(兽用,可生产3ml以上规格胶囊)
3、胶囊预制模具
4、各种漏斗、预混机及电子包被机等

日本 CLEA Japan 特殊实验配方饮食 Formula Diets for Special Experiments

日本 CLEA Japan 特殊实验配方饮食 Formula Diets for Special Experiments
上海金畔生物代理日本CLEA Japan 公司饲料,欢迎客户访问CLEA Japan 官网或者咨询我们获取更多相关产品信息。

Drug-containing Diets 含药饲料
Purified Diets 纯化饲料
AIN Purified Basic Formula Diet AIN精制基础配方饲料
Specified Formula Diets 指定配方饲料
Various Diet Materials 各种膳食材料
Special Form Diets, Imported Diets 特殊形式的饲料,进口的饲料
Past Record of Special Diet Manufacturing 特殊饲料制造的过去记录

Drug-containing Diets 含药饲料
We provide diets prepared from our standard products with the addition of drugs or other substances as designated; these diets are applicable to pharmacology or toxicity studies.
我们提供由我们的标准产品准备的饮食,添加指定的药物或其他物质;这些饮食适用于药理学或毒性研究。

饮食编号 产品 Products
D15001 CE-2+2%胆固醇1%胆酸5%棕榈油 CE-2 + 2% cholesterol, 1% cholic acid, 5% palm oil
D15002 CE-2+1%胆固醇,0.5%胆酸,10%棕榈油 CE-2 + 1% cholesterol, 0.5% cholic acid, 10% palm oil
D15010 CE-2+1%胆固醇,0.5%胆酸钠 CE-2 + 1% cholesterol, 0.5% sodium cholate
D15020 CE-2+1%胆固醇,0.2%胆酸钠,5%橄榄油 CE-2 + 1% cholesterol, 0.2% sodium cholate, 5% olive oil
D15030 CE-2+3%胆固醇,15%黄油 CE-2 + 3% cholesterol, 15% butter
D15040 CE-2+牛油粉 CE-2 + powdered beef tallow
D25001 CR-3+2%胆固醇6%花生油 CR-3 + 2% cholesterol, 6% peanut oil
D25010 CR-3+1%胆固醇 CR-3 + 1% cholesterol
D25011 CR-3+2%胆固醇 CR-3 + 2% cholesterol
D15100 CE-2+3%NaCl CE-2 + 3% NaCl
D15101 CE-2+8%NaCl CE-2 + 8% NaCl
D15000 小鼠和大鼠饮食+其他提供的药物 Diets for mice and rats + other provided drugs
D25000 兔子饮食+其他提供的药物 Diets for rabbits + other provided drugs
D35000 豚鼠饮食+其他提供的药物 Diets for guinea pigs + other provided drugs
D45000 狗的饮食+其他提供的药物 Diets for dogs + other provided drugs
D55000 猴子饮食+其他提供的药物 Diets for monkeys + other provided drugs
D 65000 其他饮食+其他提供的药物 Other diets + other provided drugs

Purified diets  纯化饲料
These diets are prepared from purified materials (casein, various sugars, etc.) for which the contents and origins of various nutrients are clearly known. These diets are widely applicable to situations in which the adjustment of specific nutrients is needed (which can be difficult using natural materials), to situations in which the preparation of a pathological status is required (such as a deficiency or an excess of specific vitamins or minerals), and for various nutritional studies.
 Basic diet
< CLEA purified basic formula diet > 
CLEA purified basic formula diet is designed by combining purified raw materials for which the origins of the nutrients are definitely known. This diet allows us to readily prepare deficiencies or excesses of nutrients (vitamins, minerals, etc.) that are difficult to adjust when using natural raw materials.
< AIN purified basic formula diets > 
These diets are the standard purified diets proposed by the American Institute of Nutrition (AIN) in 1977 (AIN-76) and 1993 (AIN-93) for use in nutritional studies using mice or rats. The compositions of these diets were determined by the AIN based on the nutritional requirements of mice and rats issued by the National Academy of Sciences National Research Council (NAS-NRC), which were determined using indications such as of favorable growth, pregnancy, and lactation during the year after birth.
这些饮食是由纯化的原料(酪蛋白、各种糖等)制成的。各种营养物质的含量和来源都很清楚。这些饮食广泛适用于需要调整特定营养物的情况(使用天然材料可能很困难)、需要准备病理状态的情况(例如缺乏或过量的特定维生素或矿物质),以及各种营养研究。
基本饮食
< CLEA purified basic formula diet > 
Clea纯化的基本配方饮食是通过组合纯化的原料来设计的,这些原料的营养来源是非常清楚的。这种饮食使我们可以随时准备营养不足或过量(维生素、矿物质等)。在使用天然原料时很难调整。
< AIN purified basic formula diets > 
这些饮食是美国营养研究所(AIN)在1977年(AIN-76)和1993年(AIN-93)提出的标准纯化饮食,用于使用小鼠或大鼠的营养研究。这些饮食的组成由AIN根据国家科学院国家研究委员会(NAS-NRC)发布的小鼠和大鼠的营养需求来确定。

CLEA purified basic formula diet
Milk casein 牛奶酪蛋白 24.50%
Cornstarch 玉米淀粉 45.50%
Granulated sugar 砂糖 10.00%
Corn oil 玉米油 6.00%
Crystalline cellulose 结晶纤维素 3.00%
Cellulose powder 纤维素粉 2.00%
Okanol (pregelatinized starch)* 奥卡诺(预糊化淀粉)* 1.00%
Vitamin mix (for CLEA purified diet) 维生素混合物(用于洁净饮食) 1.00%
Mineral mix (for CLEA purified diet) 矿物混合物(用于Clea纯饲料) 7.00%
Total 共计 100.00%

*Potato starch  *马铃薯淀粉

AIN purified basic formula diets   AIN-76 AIN-93G* AIN-93M*
Cornstarch 玉米淀粉 15.00% 39.75% 46.57%
Milk casein 牛奶酪蛋白 20.00% 20.00% 14.00%
Pregelatinized cornstarch 预变性玉米淀粉 13.20% 15.50%
Granulated sugar 砂糖 50.00% 10.00% 10.00%
Purified soybean oil 纯化大豆油 7.00% 4.00%
Cellulose powder 纤维素粉 5.00% 5.00% 5.00%
Mineral mix (AIN-93M-MX) 矿物混合(AIN-9300万-MX) 3.50% 3.50% 3.50%
Vitamin mix (AIN-93VX) 维生素混合物(AIN-93VX) 1.00% 1.00% 1.00%
L-cystine L-胱氨酸 0.30% 0.18%
Choline bitartrate 酒石酸胆碱 0.20% 0.25% 0.25%
Tertiary butylhydroquinone 叔丁基对苯二酚 0.00% 0.00%
DL-methionine DL-蛋氨酸 0.30%
Corn oil 玉米油 5.00%

*Composition of powdery diets. For solid diets, part of the pregelatinized cornstarch is replaced with cornstarch.  *粉状饮食的组成。对于固体饮食,部分预糊化玉米淀粉被玉米淀粉取代。
Examples of purified diet manufacturing  纯饲料生产实例

  • Protein formula diet: adjustment of protein quantities and alterations in the protein material
  • Fat formula diet: adjustment of the fat quantities and alteration of the fat material (high-fat diet, low-fat diet)
  • Vitamin formula diet: adjustment of the amounts of vitamins added or no addition of vitamins
  • Mineral formula diet: adjustment of the amounts of minerals added or no addition of minerals
  • 蛋白质配方饮食:蛋白质量的调整和蛋白质材料的改变
  • 脂肪配方饮食:调整脂肪数量和改变脂肪物质(高脂饮食,低脂肪饮食)
  • 维生素配方饮食:调整维生素添加量或不添加维生素
  • 矿物配方饮食:调整矿物质添加量或不添加矿物质

For special formula diets including those other than the above, consult the diet division of our company.   如需特殊配方饲料,请咨询本公司的饮食部门。
AIN purified basic formula diets  AIN精制基础配方饲料
hese diets are standard purified diets proposed by the American Institute of Nutrition (AIN) in 1977 (AIN-76) and 1993 (AIN-93) for use in nutritional studies using mice and rats. The compositions of these diets were determined by the AIN based on the nutritional requirements of mice and rats issued by the National Academy of Sciences National Research Council (NAS-NRC), which were determined using indications such as of favorable growth, pregnancy, and lactation during the year after birth.
这些饮食是美国营养研究所(AIN)在1977年(AIN-76)和1993年(AIN-93)提出的标准纯化饲料,用于使用小鼠和大鼠的营养研究。这些饮食的组成由AIN根据国家科学院国家研究委员会(NAS-NRC)发布的小鼠和大鼠的营养需求来确定。
AIN-76 purified basic formula diet     纯基本配方饮食

Composition
Milk casein 牛奶酪蛋白 20.00%
DI-methionine 二蛋氨酸 0.30%
Cornstarch 玉米淀粉 15.00%
Granulated sugar 砂糖 50.00%
Cellulose powder 纤维素粉 5.00%
Corn oil 玉米油 5.00%
Vitamin mix (AIN-76) 维生素混合物(AIN-76) 1.00%
Mineral mix (AIN-76) 矿物混合(AIN-76) 3.50%
Choline bitartrate 酒石酸胆碱 0.20%
100.00%

 

AIN-76 vitamin mix
Vitamin A (1,000,000 IU/g) 维生素A(1 000 000 IU/g) 0.08%
Vitamin D3 (500,000 IU/g) 维生素D 3(500 000 IU/g) 0.02%
Vitamin E (50%) 维生素E(50%) 1.00%
Vitamin B1 维生素B1 0.06%
Vitamin B2 维生素B2 0.06%
Vitamin B6 维生素B6 0.07%
Vitamin B12(0.1%) 维生素B12(0.1%) 0.10%
Nicotinic acid 烟酸 0.30%
Calcium pantothenate 泛酸钙 0.16%
Folic acid 叶酸 0.02%
Biotin (2%) 生物素(2%) 0.10%
Vitamin K3 维生素K3 0.00%
Granulated sugar 砂糖 97.95%
100.00%

 

AIN-76 mineral mix
CaHPO4・2H2O CaHPO4·2H2O 50.00%
Nacl 氯化钠 7.40%
K3C6H5O5・H2O K3C6H5O5·H2O 22.00%
K2SO4 K2SO4 5.20%
MgO 氧化镁 2.40%
MnCO3 MnCO3 0.35%
FeC6H5O7・5H2O FeC6H5O7・5H2O 0.60%
5ZnO・2CO2・4H2O 5ZnO·2CO2·4H2O 0.16%
CuCO3Cu(OH)2・H2O 库科3Cu(OH)2·H2O 0.03%
KIO3 KIO3 0.00%
Na2SeO3・5H2O Na2SeO3・5H2O 0.00%
CrK(SO4)2・12H2O CrK(SO4)2・12H2O 0.06%
Granulated sugar 砂糖 11.80%
100.00%

AIN-93 purified basic formula diet    AIN-93纯天然配方奶

Conposition
AIN-93G AIN-93M
(Breeding for pregnancy lactation) (for Maintenance)
Cornstarch 玉米淀粉 39.75% 46.57%
Milk Casein 牛奶酪蛋白 20.00% 14.00%
Pregelatinized cornstarch 预变性玉米淀粉 13.20% 15.50%
Granulated sugar 砂糖 10.00% 10.00%
Purified soybean oil 纯化大豆油 7.00% 4.00%
Cellulose powder 纤维素粉 5.00% 5.00%
Mineral mix 矿物混合 (AIN-93G-MX) 3.5% (AIN-93M-MX) 3.5%
Vitamin mix 维生素混合 1.00% 1.00%
(AIN-93VX) (AIN-93VX)
L-Cystine L-胱氨酸 0.30% 0.18%
Choline bitartrate 酒石酸胆碱 0.25% 0.25%
Tertiary butylhydroquinone 叔丁基对苯二酚 0.00% 0.00%
100.00% 100.00%

 

AIN-93VX Vitamin mix
Nicotinic acid 烟酸 0.30%
Dl-Calcium pantothenate DL-泛酸钙 0.32%
Vitamin B6 维生素B6 0.07%
Vitamin B1 维生素B1 0.06%
Vitamin B2 维生素B2 0.06%
Folic acid 叶酸 0.02%
D-biotin (2%) D-生物素(2%) 0.10%
Vitamin B12(0.1%) 维生素B12(0.1%) 0.25%
Vitamin E(50%) 维生素E(50%) 1.50%
Vitamin A(500,000IU/g) 维生素A(50万IU/g) 0.08%
Vitamin D3(500,000IU/g) 维生素D3(50万IU/g) 0.02%
Vitamin K1(phylloquinone) 维生素K1(卟啉醌) 0.01%
Granulated sugar 砂糖 97.21%
100.00%

 

Mineral mix
AIN-93G-MX AIN-93M-MX
CaCO3 碳酸钙3 35.70% 35.70%
KH22PO4 KH22PO4 19.60% 25.00%
K3C6H5O7・H2O K3C6H5O7·H2O 7.08% 2.80%
NaCl 氯化钠 7.40% 7.40%
K2SO4 K2所以4 4.66% 4.66%
MgO 乐高 2.40% 2.40%
FeC6H5O7・H2O FEC6H5O7·H2O 0.61% 0.61%
5ZnO・2CO2・H2O 5ZnO·2CO2·H2O 0.17% 0.17%
MnCO3 MnCO3 0.06% 0.06%
CuCO3Cu(OH)2・H2O 库科3Cu(OH)2·H2O 0.03% 0.03%
KIO3 KIO3 0.00% 0.00%
Na2SeO4 2SEO4 0.00% 0.00%
(NH4)6Mo7O24・4H2O (NH)4)6Mo7O24·4H2O 0.00% 0.00%
Na2SiO3・9H2O 2SiO3·9H2O 0.15% 0.15%
CrK(SO4)2・12H2O 克尔克4)2·12H2O 0.03% 0.03%
H3BO3 H33 0.01% 0.01%
NaF 纳法 0.01% 0.01%
NiCO3・2Ni(OH2)・4H2O 尼科3·2Ni(OH)2)·4H2O 0.00% 0.00%
LiCl 氯化锂 0.00% 0.00%
NH4VO3 4Vo3 0.00% 0.00%
Granulated sugar 砂糖 22.10% 22.10%

Special Formula Diets   特殊配方饲料
These diets are based on our standard products with some modifications in composition (e.g., the removal or increase in the quantity of a particular ingredient).
这些饮食是以我们的标准产品为基础,并对成分进行了一些修改(例如,去除或增加某一特定成分的数量)。

Diet No. Product
CLEA Diet No.001 CR-3 without alfalfa
CLEA Diet No.002 CR-3 without alfalfa and Vit. C
CLEA Diet No.005 CE-2 low fat
CLEA Diet No.006 CE-2 low Ca
CLEA Diet No.007 CE-2 sorbic acid 15%
CLEA Diet No.008 CA-1 low iodine
CLEA Diet No.009 CA-1 low selenium
CLEA Diet No.010 CA-1 low sodium
CLEA Diet No.011 CE-2 low iodine
CLEA Diet No.012 CE-2 without fish flour
CLEA Diet No.013 CA-1 Ca 1%
CLEA Diet No.014 CG-7 low Vit. C
CLEA Diet No.015 CE-2 Na-free
CLEA Diet No.016 CR-3 without soybean oil + 1.2% lard

Various Diet Materials   各种饲料材料
We provide single items of various natural materials and purified diets for sale.
我们提供单一项目的各种天然材料和纯化饮食出售。

 Protein materials 蛋白质材料
Milk casein 牛奶酪蛋白
Vitamin-free casein 无维生素酪蛋白
Egg white powder 蛋清粉
Purified soybean protein 纯化大豆蛋白
Edible soybean protein 食用大豆蛋白
 Fat materials  脂肪材料 
[Vegetable] [蔬菜]
Corn oil 玉米油
Purified soybean oil 纯化大豆油
Palm oil (coconut oil) 棕榈油(椰子油)
[Animal] [动物]
Purified lard 纯化猪油
Powdered beef tallow 牛油粉
 Carbohydrate materials  碳水化合物材料 
Cornstarch (raw starch/corn) 玉米淀粉(生淀粉/玉米)
Granulated sugar (sucrose) 砂糖(蔗糖)
Okanol (pregelatinized starch/potato) 奥卡诺(预糊化淀粉/马铃薯)
Pregelatinized cornstarch (corn) 预变性玉米淀粉(玉米)
 Fiber materials  纤维材料 
Filter paper powder 滤纸粉
Crystalline cellulose 结晶纤维素
Cellulose powder 纤维素粉
Vitamin mix, mineral mix 维生素混合物
For CLEA purification For CLEA purification
AIN-76 AIN-76
AIN-93 AIN-93
Harper Harper

Past Record of Special Diet Manufacturing   特之前销售殊饲料制造
Low-zinc diet (Diet No. A12551)   低锌饲料(塑料编号 A12551)

Composition

Cornstarch

30%

Granulated sugar

33%

Egg white powder

20%

Corn oil

5%

Cellulose powder

3%

Okanol

1%

Vitamin mix (purified)

1%

Mineral mix

7%

 

100%

 

Mineral mix (in 100 g of diet)  矿物混合(100克膳食)

CaCO3

1355.40mg

KH2PO4

1730.00mg

CaHPO4・2H2O

1500.00mg

MgSO4・7H2O

800.00mg

Nacl

600.00mg

FeC6H5O7・5H2O

190.00mg

CuSO4・5H2O

1.26mg

CoCl2・6H2O

0.40mg

Ca(IO3)2

1.54mg

MnSO4・4H2O

15.40mg

Cornstarch

801.26mg

 

7000.00mg

Analytical values

  1. Zn 0.11 mg% formula O-7290 analysis E-1219 (Dec. ‘87)
  2. Zn 0.22 mg% formula O-9279 analysis E-1682 (Oct. ‘89)
  3. Zn 0.20 mg% formula O-9286 analysis E-1693 (Oct. ‘89)
  4. Zn 0.38 mg% formula O-1057 analysis E-2053 (Feb. ‘91)
  5. Zn 0.18 mg% formula O-1216 analysis E-2053 (Jul. ‘91)

Other diets

  • Bile stone-producing diet (for hamsters) 产胆结石的食物(为仓鼠)
  • Low choline, protein formula diet  低胆碱、蛋白质配方饮食
  • Low-sodium diet  低钠饮食
  • Low-magnesium diet  低镁饮食
  • Low-iron diet  低铁饮食
  • Low-vitamin diet  低维生素饮食
  • Low-calcium diet  低钙饮食
  • 0.5% Calcium diet  0.5%钙饮食
  • Low-potassium diet  低钾饮食
  • Low-selenium diet  低硒饮食
  • Low-copper diet  低铜饮食

日本 CLEA Japan 普通饲料General Diets

日本 CLEA Japan 普通饲料General Diets
上海金畔生物代理日本CLEA Japan 公司饲料,欢迎客户访问CLEA Japan 官网或者咨询我们获取更多相关产品信息。

CA-1 (for breeding) CA-1(用于育种)
CE-2 (for rearing and breeding) Ce-2(用于饲养和育种)
CE-7 (for long-term rearing) CE-7(长期饲养)
CL-2 (for germ-free and immunodeficient animals) Cl-2(用于无菌和免疫缺陷动物)
B·F (for weaning) B·F(用于断奶)
Quick Fat (for diabetes and obesity research) 快速脂肪(用于糖尿病和肥胖研究)
High Fat Diet 32 (for diabetes and obesity researc) 高脂饮食32(糖尿病和肥胖研究)
CR-3 (for rearing) CR-3(用于饲养)
CG-7 (for rearing and breeding) CG-7(用于饲养和繁殖)
CD-5M (for breeding and rearing) 镉-5米(用于繁殖和饲养)
CMK-2 (for rearing) CMK-2(用于饲养)
CMS-1M (for breeding and rearing) CMS-1M(用于育种和饲养)
M-16 M-16

For mice, rats, and hamsters   对于老鼠、老鼠和仓鼠
OA-2
CA-1
CE-2
CE-7
CL-2
B・F
For diabetes and obesity studies (for mice and rats)   糖尿病和肥胖研究(老鼠和大鼠)
Quick Fat  快速脂肪
High Fat Diet 32     高脂饮食32
For rabbits and guinea pigs  兔和豚鼠
CR-3
CG-7
For dogs    狗饲料
CD-5M
For monkeys     猴子
CMK-2
CMS-1M
For miniature pigs 小型猪饲料
M-16

日本 CLEA Japan品牌饲料 CLEA Rodent Diet CA-1 (for breeding)

日本 CLEA Japan品牌饲料 CLEA Rodent Diet CA-1 (for breeding)

CLEA Japan, Inc
This diet is a Good Laboratory Practice (GLP)-compliant diet consisting mainly of animal protein (whitefish meal) with a proper balance of cereals and enriched with protein content and minerals. This diet is designed for the breeding of inbred animals.
对于老鼠、老鼠和仓鼠–Clea啮齿动物日粮CA-1(用于繁殖)
这种饮食是一个良好的实验室实践(GLP)的饮食,主要由动物蛋白质(白粉)与适当的平衡谷类和丰富的蛋白质含量和矿物质。这种饮食是为繁殖近交系动物而设计的。

Ingredients Protein source whitefish meal, soybean meal, yeast, fish liver powder
Fat source cereal germ, soybean oil
Fiber source wheat bran, defatted rice bran, alfalfa meal
Carbohydrate source wheat flour, corn, milo
Vitamins Vit. A, D3, E, B1, B2, B6, B12, C, niacin, pantothenic acid, biotin, folic acid, choline chloride, inositol
Minerals calcium carbonate, salt, ferrous sulfate, manganese sulfate, cobalt sulfate, calcium iodate
Mean values from regular analyses in fiscal 2017
Nutrient components and calories
(in 100 g)
(All production lots analyzed)
Moisture (%) 8.48
Crude protein (%) 27.09
Crude fat (%) 4.69
Crude fiber (%) 4.54
Crude ash (%) 7.92
NFE (%)*1 47.28
Energy (kcal)*1,2 339.7
Hardness (kg/cm2) 24.7
*1Calculated from mean values.
*2Calculated by multiplying crude protein (4), crude fat (9), and NFE (4).
Minerals (in 100 g)
(All production lots analyzed for Ca and P. Other minerals subjected to semiannual analyses)
Ca (g) 1.54
P (g) 1.32
Mg (g) 0.32
K (g) 0.86
Mn (mg) 11.33
Fe (mg) 29.90
Cu (mg) 0.78
Zn (mg) 7.00
Na (g) 0.42
Ca/P*1 1.17
Ca/Mg*1 4.83
K/Na*1 2.07
*1Calculated from mean values.
Vitamin (in 100g)
(Semiannual analyses)
Retinol (IU) 2730
Vitamin B1 (mg) 1.9
Vitamin B2 (mg) 1.4
Vitamin B6 (mg) 1.2
Vitamin B12 (μg) 6.2
Total vitamin C (mg) 23
Vitamin D3 (IU) 290
Vitamin E (mg) 7.5
Pantothenic acid (mg) 2.4
Niacin (mg) 19.6
Folic acid (mg) 0.2
Choline (g) 200
Biotin (μg) 52.8
Inositol (mg) 565
Form Pellet (12.5 mm in diameter), powder (*made-to-order)
Volume 20kg
Package Paper bag (3-layer craft + 1-layer plastic bag)

 

配料 蛋白源 白粉,豆粕,酵母,鱼肝粉
脂肪源 谷类胚芽、大豆油
光纤源 麦麸,脱脂米糠,苜蓿粉
碳水化合物源 小麦粉,玉米,米洛
维生素 维特。A,D3,E,B1,B2,B6,B12,C,烟酸,泛酸,生物素,叶酸,氯化胆碱,肌醇
矿物 碳酸钙,盐,硫酸亚铁,硫酸锰,硫酸钴,碘酸钙
2017年财政分析的平均值
营养成分和卡路里
(100克)
(分析所有生产批次)
水分(%) 8.48
粗蛋白(%) 27.09
粗脂肪(%) 4.69
粗纤维(%) 4.54
粗灰分(%) 7.92
NFE(%)*1 47.28
能源(千卡)*1,2 339.7
硬度(公斤/厘米)2) 24.7
*1根据平均值计算。
*2用粗蛋白(4)、粗脂肪(9)和NFE(4)相乘计算。
矿物(100克)
(对Ca和P.的所有生产批次进行半年一次的分析)
CA(G) 1.54
P(G) 1.32
镁(G) 0.32
k(G) 0.86
锰(镁) 11.33
Fe(Mg) 29.90
Cu(Mg) 0.78
锌(镁) 7.00
NA(G) 0.42
CA/P*1 1.17
Ca/Mg*1 4.83
K/Na*1 2.07
*1根据平均值计算。
维生素(100克)
(半年分析)
视黄醇(IU) 2730
维生素B1(毫克) 1.9
维生素B_2(Mg) 1.4
维生素B6(毫克) 1.2
维生素B1 2(μg) 6.2
总维生素C(毫克) 23
维生素D 3(IU) 290
维生素E(Mg) 7.5
泛酸(Mg) 2.4
烟酸(Mg) 19.6
叶酸(Mg) 0.2
胆碱(G) 200
生物素(μg) 52.8
肌醇(Mg) 565
形式 球团(直径12.5毫米),粉末(*按订单制作)
体积 20公斤
包装 纸袋(3层工艺+1层塑料袋)

上海金畔生物科技有限公司(www.jinpanbio.com)提供生命科学研究领域系列产品,包括生化试剂、诊断试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料;修饰性PEG(Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG);Sigma、Amresco、TCI、MP bio生化试剂;WAKO日本和光纯药、日本关东化学Kanto试剂、日本三菱、日本柴田科学SIBATA;Megazyme食品分析检测试剂盒、日本共立理化学;Research diets、Harlan饲料、Bio-Serv、日本CLEA Japan品牌的动物饲料;Oxoid、Nissui日水、日本荣研、BD difco、Himedia品牌微生物培养基;免疫诊断试剂包括:Bethyl抗体;Biolegend流式抗体、Abcam、CST、Santa Cruz抗体;Roche、TOYOBO、NEB品牌的酶;中检所、TRC、药典USP、EP、Reagecon标准品;耗材和仪器包括Whatman、日本Advantec滤膜、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Wheaton瓶子、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
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Research diets饲料问题答疑

Research diets饲料问题答疑
上海金畔生物代理Research Diets品牌饲料,欢迎客户访问Research Diets品牌官网或者咨询我们获取更多饲料价格等相关信息。
Research Diets 公司是一家专业的生产科研实验室动物饲料的大型公司,产品包括高脂、高糖、脂肪肝、酒精肝、动脉硬化、缺铁性贫血饲料、骨质疏松饲料等饲料的世界著名的供应商。
Q: 1.包装尺寸怎样?
A:Research Diet公司商品的包装尺寸为12.5kg/箱。
基本上Research Diet商品的销售单位为12.5kg。备选的(费用另算)也有
2.5kg >x 5袋的小袋包装。
Q: 2.从订单发行到交货要多长时间?
A: 特供饲料在性质上,大多是收到订单后才开始生产,除了一部分标准商品在国内有库存。此外由于是特殊饲料,Research Diet公司也将库存量压到最小量,几乎都采用JUST IN TIME(准时生产)的方式。关于交货期,在收到订单之后,大约3周后。国内部分产品备有现货。
Q: 3.保存方法如何?
A:多数的Research Diet商品都可以在室温(阴暗场所)保存。在多湿气的冰箱中长期保存,可能会吸收冰箱中的异味。因此请注意保管室提高袋子的密封性。D12492、D12331等超高脂肪饲料的情况下,如果是固态饲料,为了保持其颗粒形状,建议进行冷冻保存。但是,粉末饲料的情况下,由于其组成为脂肪酸,进行冷冻保存的话,会结块,因此取出放入时,注意不要让空气进入,并且收紧袋口,确认其密封性,最好冷藏保存。
Most diets require storage in a cool, dry location. Some diets, especially those with high fat content, are best if kept frozen. Storage requirements are indicated on top of each carton.
Q: 4.品质保存期限是多久?
A:Research Diet饲料的品质保存期限是从生产日开始6个月。送达的商品中会附加如下的标签。从上到下分别为商品名、明细、保存状态、品质保存期限、批号(批号的前6表示生产年月日。如:03_01_15的意思是 2003年1月15日。
例如:
D12492
带有60 kcal% 脂肪的啮齿动物饲料
蓝色
冷冻保存, 有效期: 7月15日
Lot # 03011501
Shelf Life(保质期)
In proper storage conditions OpenSource Diets will last six (6) months. All diets are labeled with an expiration date.
Q: 5.成分、污染物以及重金属分析情况如何?
A:由于是纯化饲料,因此没有进行成分、污染物以及重金属的分析。可以对备选饲料(费用按照实际成本)实施分析。关于费用等详细情况,请进行咨询。
Q: 6.何为“纯化”饲料的脂肪和油脂?
A:经常听到“添加17-20g%以上的脂肪,很难使饲料固体化”,而Research Diet公司通过独有的生产法,做到了60 kcal% fat,质量换算后达到35%。
Q: 7.能否生产和我现在使用的相同饲料?
A:客户如果有自己配方的饲料或者从其他公司生产的饲料,Research Diet公司可以根据客人希望的形状(颗粒、粉末、液体、片剂)生产出与之相同的饲料。此外两周内可以出货。
Q: 8.Research Diet公司饲料的对象动物种类是哪些?
A:Research Diet公司的配方适合大鼠、老鼠、豚鼠,仓鼠、兔子、猫、犬、猴、鸟、豚等所有用途的饲料。
Q: 9.可以公开配方吗?
A:Research Diet公司将含有的全部盐分和维他命成分以及其正确的含量记载在成分表上,可以将该表提交给客户。
Q: 10.保密性如何?
A:Research Diet公司与全球的制药公司、政府机关以及教育机关都有交易,在对客户信息保密方面受到了好评。当然,没有客户事先的同意,有关客户所购入的饲料或者客户正在进行的试验,Research Diet公司绝对不会进行公开。
Q: 11.饲料能否实施消毒?
A:Research Diet公司几乎所有的饲料在封闭环境中可以照射伽马线。纯化饲料的情况下,推荐使用10KGy的射线。希望消毒的客户请向我们咨询。
Q: 12.可以通过怎样的形状进行使用?
A:Research Diet公司几乎所有的饲料都可以生产成为粉末、颗粒、片剂以及液体。 通过Research Diet公司独有的技术,也可以生产出60 kcal%(重量±35%)的高脂肪含量的颗粒状饲料。
Research diets高脂饲料专业代理:

货号 产品名称和描述 研究领域 重量单位
D12450B 精制饲料 DIO饲料 10 Kcal%脂肪(猪油) 肥胖/糖尿病 1箱 12.5 kg
D12451 精制饲料 DIO饲料 45 Kcal%脂肪(猪油) 肥胖/糖尿病 1箱 12.5 kg
D12492 精制饲料 DIO饲料 60 Kcal%脂肪(猪油) 肥胖/糖尿病 1箱 12.5 kg
D12079B 精制饲料 Western饲料 41Kcal%乳脂(牛) 肥胖 1箱 12.5 kg
D10001 精制饲料 AIN-76A标准饲料 标准饲料 1箱 12.5 kg
D10012G 精制饲料 AIN-93G标准饲料 用于训练动物 标准饲料 1箱 12.5 kg
D10012M 精制饲料 AIN-93M标准饲料 用于成熟动物 标准饲料 1箱 12.5 kg
D11724 精制饲料 高碳水化合物型低脂肪饲料(玉米淀粉) 糖尿病 1箱 12.5 kg
D11725 精制饲料 高碳水化合物型低脂肪饲料(高蔗糖) 糖尿病 1箱 12.5 kg
D12331 精制饲料 Surwit’s饲料 58Kcal%脂肪(椰子油、玉米淀粉) 糖尿病 1箱 12.5 kg
D12336 精制饲料 心血管疾病的饲料 高胆固醇 循环器官 1箱 12.5 kg

Research Diets D12108C 高脂饲料(含1.25%胆固醇)

Research Diets D12108C 高脂饲料(含1.25%胆固醇)
上海金畔生物代理Research Diets品牌饲料,欢迎客户访问Research Diets品牌官网或者咨询我们获取更多饲料价格等相关信息。
美国Research Diets公司是一家专业生产实验室动物饲料的顶尖公司,还可以根据客户要求定制特殊饲料,满足客户多方面需求。
Research Diets 公司是一家专业的生产科研实验室动物饲料的大型公司,产品包括高脂、高糖、脂肪肝、酒精肝、动脉硬化、缺铁性贫血饲料、骨质疏松饲料等饲料的世界著名的供应商。
Research Diets D12108C 高脂饲料(含1.25%胆固醇)
货号:D12108C
英文名:High fat rodent diet with 1.25% cholesterol
品牌:Research Diets
我司所销售的化学试剂、原料等所有产品(包括但不限于抗生素类、蛋白质类、试剂盒类产品等)仅限用于科学研究用途,不得作用于人体。

Description
High fat rodent diet with 1.25% cholesterol.
Used in Research
Atherosclerosis
Often used with Apo E or LDLR knockout mice
Replaces
D12108 with used alcohol-extracted casein, which is not believed to be important in inducing an athero phenotype.
Packaging
Product is packed in 12.5 kg box.
Each box is identied with the product name, description, lot number and expiration date.
Lead Time
5-7 business days.
Gamma-Irradiation
Yes. Add 10 days to delivery time.
Form
Pellet, Powder
Shelf Life
Most diets require storage in a cool dry environment. Stored correctly they should last 6 months.
Because of the high fat content is best if kept frozen.
Reference listing  参考文献:
  • Lichtman AH, Clinton S et al. Hyperlipidemia and Atherosclerosclerotic Lesion Development in LDL Receptor-Deficient Mice Fed Defined Semi purified Diets With and Without Cholate. Arteriosclerosis, Thrombosis and Vascular Biology. 1999; 19:1938-1944.
  • Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M, Davis V, Gutierrez-Ramos J-C, Connelly PW, & Milstone DS. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J. Clin. Invest. 107:1255-1262, 2001.
  • Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation. 2006 Jul 4;114(1):55-62. Epub 2006 Jun 26.
  • Xie D, Hazarika S, Andrich AJ, Padgett ME, Kontos CD, Donatucci CF, Annex BH. High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue. J Sex Med. 2008 May;5(5):1137-48.
  • Aslanian AM, Charo IF. Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Circulation. 2006 Aug 8;114(6):583-90. Epub 2006 Jul 31.
  • Chiba T, Shinozaki S, Nakazawa T, Kawakami A, Ai M, Kaneko E, Kitagawa M, Kondo K, Chait A, Shimokado K. Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice. Atherosclerosis. 2008 Jan;196(1):68-75. Epub 2007 Mar 23.
  • Martens GW, Arikan MC, Lee J, Ren F, Vallerskog T, Kornfeld H. Hypercholesterolemia impairs immunity to tuberculosis. Infect Immun. 2008 Aug;76(8):3464-72. Epub 2008 May 27.
  • Wolfrum S, Teupser D, Tan M, Chen KY, Breslow JL. The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18601-6. Epub 2007 Nov 15.
  • Trogan E, Feig JE, Dogan S, Rothblat GH, Angeli V, Tacke F, Randolph GJ, Fisher EA. Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3781-6. Epub 2006 Mar 1.

Research Diets动物模型饲料份分类

Research Diets动物模型饲料份分类

美国Research Diets公司是一家专业生产实验室动物饲料的顶尖公司,还可以根据客户要求定制特殊饲料,满足客户多方面需求。
Research Diets 公司是一家专业的生产科研实验室动物饲料的大型公司,产品包括高脂、高糖、脂肪肝、酒精肝、动脉硬化、缺铁性贫血饲料、骨质疏松饲料等饲料的世界著名的供应商。
详细信息

美国Research Diets公司是一家专业生产实验室动物饲料的顶尖公司,还可以根据客户要求定制特殊饲料,满足客户多方面需求。自1984年以来,Research Diets已成功开发了10,000种独特的实验室动物模型饲料,覆盖了生命科学的大部分研究领域。
动物模型
Research Diets在表型表达的饮食效应上拥有20年的研发经验,已成功研发了几种模型的饲料,如肥胖症、糖尿病、代谢综合征、动脉粥样硬化、癌症、骨质疏松等。Research Diets的饲料有多种形式:粉末状、颗粒状及液态形式。

适用动物
生产的饲料适用的动物有:大鼠、小鼠、豚鼠、仓鼠、兔子、猪及灵长类动物等。

Cat# 品名 应用 包装
D12450B DIO (LFD) 10 kcal% fat 肥胖、糖尿病 12.5kg
D12451 DIO (HFD) 45 kcal% fat 肥胖、糖尿病 12.5kg
D12492 DIO (VHFD) 60 kcal% fat 肥胖、糖尿病 12.5kg
D10001 AIN-76A 肥胖、糖尿病、 骨质疏松症、高血压、动脉粥样硬化、代谢综合症 12.5kg
D10012G AIN-93G 肥胖、糖尿病、 骨质疏松症、高血压、动脉粥样硬化、代谢综合症 12.5kg
D10012M AIN-93M 肥胖、糖尿病、 骨质疏松症、高血压、动脉粥样硬化、代谢综合症 12.5kg
D12266B Condensed Milk Diet Purified match to C11024 肥胖、糖尿病、高血压 12.5kg
D12489B Low-fat control to D12266B 肥胖、糖尿病、高血压 12.5kg
D12079B RD Western Diet 肥胖、糖尿病、 骨质疏松症、高血压、动脉粥样硬化、代谢综合症 12.5kg
D12330 58 kcal% fat w/corn starch 肥胖、糖尿病 12.5kg
D12328 Control: 11 kcal% fat w/corn starch 肥胖、糖尿病 12.5kg
D12331 58 kcal% fat w/sucrose 肥胖、糖尿病 12.5kg
D12329 Control: 11 kcal% fat w/sucrose 肥胖、糖尿病 12.5kg

Research Diets A02082002B MCD饲料-非酒精性脂肪肝模型饲料

Research Diets A02082002B MCD饲料-非酒精性脂肪肝模型饲料
英文名称:methionine-choline deficient diet, MCD
产地/品牌:Research Diets
产品类别:非酒精性脂肪肝模型饲料
Research Diets 公司是一家专业的生产科研实验室动物饲料的大型公司,产品包括高脂、高糖、脂肪肝、酒精肝、动脉硬化、缺铁性贫血饲料、骨质疏松饲料等饲料的世界著名的供应商。
非酒精性脂肪性肝病(NAFLD)是全世界范围内最普遍的一种肝脏疾病和肝功能检测异常的最常见诱因,包含一系列的疾病状态。从最初单纯的脂肪变性(肝硬化)发展至病理性的非酒精性肝炎(Nonalcoholic steatohepatitis, NASH),进一步引起肝纤维化,甚至导致肝硬化、肝功能衰竭和肝癌等终末期肝病。NASH的发病常常与肥胖症、胰岛素抵抗、线粒体功能异常、II型糖尿病等相关。作为严重肝病发生的必经阶段,对NASH发病机制的认识和治疗极具重要性。
目前对NASH发病机制和评估治疗成效的研究主要以合适的动物模型为平台。营养诱发动物模型(食物喂养法)是NASH动物模型建立最常用的方法。其中MCD(methionine-cholinedeficient diet)和HFD(high-fat diet)为诱导NASH的两种常见饲料,研究者可根据各个方法的成模特征、周期、动物类型等选择适宜的方法。
专题一 NASH动物模型(MCD法)
简 介
蛋氨酸/胆碱缺乏饲料(methionine-choline deficient diet, MCD)是最经典的建立NASH动物模型的方法,已经具有40多年的应用历史。一般选用啮齿类动物。是研究NASH疾病相关的炎症、氧化应激、线粒体损伤、肝纤维化的最佳建模方法。
Mpbio公司提供两种类型的MCD动物饲料,分别是粉末状(powder)和颗粒状(pellet)。另外还提供MCD对照饲料,与普通MCD饲料配方相同,只是在减少等量蔗糖的基础上,增加2g/kg 氯化胆碱和3 g/kg DL-蛋氨酸。
Research Diets A02082002B MCD饲料-非酒精性脂肪肝模型饲料
CD / MCD 特殊飼料:
Research Diets 货号  A02082002B,  methionine and choline-deficient diet (MCD)  ;
Research Diets 货号  A02082003B(MCD   contronl diets); 对照组

Harlan Teklad动物饲料目录以及Harlan饲料价格

Harlan Teklad动物饲料目录以及Harlan饲料价格
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Harlan Teklad动物饲料目录以及Harlan饲料价格

TD.94045 AIN-93G Purified Diet AIN-93G纯化饮食
TD.94048 AIN-93M Purified Diet AIN-93M纯化饮食
TD.94096 version of AIN-76A suitable for irradiation (vitamin levels are increased) 适用于辐射的AIN-76A型(维生素水平增加)
TD.97184 version of AIN-93G suitable for irradiation (vitamin levels are increased) 适用于辐照的AIN-93G版本(维生素水平增加)
TD.00102 version of AIN-93M suitable for irradiation (vitamin levels are increased) 适用于辐照的AIN-93M版本(增加维生素水平)
TD.95092 modification of AIN-93G where soybean oil is replaced with corn oil. 用玉米油代替豆油的AIN-93G的改性。
TD.06414 Adjusted Calories Diet (60/Fat) 调整后的卡路里饮食(60 /脂肪)
TD.06415 Adjusted Calories Diet (45/Fat) 调整后的卡路里饮食(45 /脂肪)
TD.03584 35% Lard Diet (Adj., No C) 35%猪油饮食(调整,否C)
TD.93075 Adjusted Calories Diet (55/fat) 调整后的卡路里饮食(55 /脂肪)
TD.95217 Adjusted Fat Diet 调整脂肪饮食
TD.96132 Adjusted Fat Diet 调整脂肪饮食
TD.88137 Adjusted Kcal Diet (42% from fat 调整后的Kcal饮食(42%来自脂肪
TD.08811 45% Kcal Fat Diet (21% MF, 2% SBO) 45%Kcal脂肪饮食(21%MF,2%SBO)
TD.06416 Adjusted Calories Diet (10/Fat) (a possible control for TD.06415 & TD.06414 listed above) 调整后的卡路里饮食(10 /脂肪)(上面列出的TD.06415和TD.06414的可能控制)
TD.08810 Low Glycemic Control Diet 低血糖控制饮食
TD.96355 Ketogenic Diet 生酮饮食
TD.84224 Essential Fatty Acid Deficient Diet 必需脂肪酸缺乏饮食
TD.88137 Adjusted Calories Diet (42% from fat) 调整后的卡路里饮食(42%来自脂肪)
TD.88051 Cocoa Butter and Purina Chow Diet 可可脂和Purina Chow饮食
TD.90221 Cocoa Butter Diet with 75% Purina Mouse (5015) 含75%Purina小鼠的可可脂饮食(5015)
TD.94059 5015, Cocoa Butter, Chol., etc. (excludes cholate) 5015,可可脂,Chol。等(不包括胆酸盐)
TD.02028 Atherogenic Rodent Diet (1.25% Chol. & 0.5% Cholic Acid) 动脉粥样硬化啮齿动物饮食(1.25%Chol。和0.5%胆酸)
TD.01383 2018 + 2% Cholesterol 2018 + 2%胆固醇
TD.86143 Vitamin A Deficient Diet 维生素A缺乏饮食
TD.89123 Vitamin D Deficient Diet 维生素D缺乏饮食
TD.88163 Vitamin E Deficient Diet 维生素E缺乏饮食
TD.95247 Folic Acid Deficient Diet 叶酸缺乏饮食
TD.80396 Iron Deficient Diet 缺铁饮食
TD.85419 Zinc Deficient Diet 锌缺乏饮食
TD.88239 Potassium Deficient Diet 缺钾饮食
TD.95027 Low Calcium Diet (0.4% P) 低钙饮食(0.4%P)
TD.96348 Diet (20% Lactose, 2% Ca, 1.25% P) 饮食(20%乳糖,2%Ca,1.25%P)
TD.92163 Selenium Deficient Diet 硒缺乏饮食
TD.95125 Iodine Deficient (0.15% PTU) 碘缺乏(0.15%PTU)
TD.93328 Protein Free Diet 无蛋白质饮食
TD.90016 6% Protein Diet 6%蛋白质饮食
TD.91352 20% Protein Diet 20%蛋白质饮食
TD.90018 40% Protein Diet 40%蛋白质饮食
TD.89247 60% Fructose Diet 60%果糖饮食
TD.86489 Diet with Adjusted Sucrose/Cornstarch 调整蔗糖/玉米淀粉的饮食
TD.96348 Diet (20% Lactose, 2% Ca, 1.25% P) 饮食(20%乳糖,2%Ca,1.25%P)
TD.98090 70% Carbohydrate Diet 70%碳水化合物饮食
TD.96355 Ketogenic Diet (almost no carbohydrate) 生酮饮食(几乎不含碳水化合物)
TD.99366 Amino Acid Diet 氨基酸饮食
TD.90262 Methionine & Choline Deficient Diet 蛋氨酸和胆碱缺乏饮食
TD.00434 Folic Acid Deficient Diet 叶酸缺乏饮食
TD.99386 No Lysine AA Diet 没有赖氨酸AA饮食
TD.90228 Sodium Deficient Diet 钠缺乏饮食
TD.96208 0.49% NaCl Diet 0.49%NaCl饮食
TD.90229 1% NaCl Diet 1%NaCl饮食
TD.92034 4% NaCl Diet 4%NaCl饮食
TD.92012 8% NaCl Diet 8%NaCl饮食
TD.01306 Rodent Diet (2018 + 625 doxycycline) 啮齿动物饮食(2018 + 625强力霉素)
TD.98186 Rodent Diet (7012 + 200 doxycycline) 啮齿动物饮食(7012 + 200强力霉素)
TD.92033 Swine Diet (15% Lard, 1.2% Cholesterol) 猪日粮(15%猪油,1.2%胆固醇)
TD.92052 Swine Diet (15% Lard, 1.5% Cholesterol) 猪日粮(15%猪油,1.5%胆固醇)
TD.93296 Swine Diet (15% Lard, 2% Cholesterol) 猪日粮(15%猪油,2%胆固醇)
CA.40060 Teklad Vitamin Mix Teklad维生素混合物
CA.40077 AIN-76A Vitamin Mix AIN-76A维生素混合物
TD.94047 AIN-93 Vitamin Mix AIN-93维生素混合物
CA.170915 AIN-76 Mineral Mix AIN-76矿物质混合物
TD.94046 AIN-93G Mineral Mix AIN-93G矿物质混合物
TD.94049 AIN-93M Mineral Mix AIN-93M矿物质混合物
TD.79055 Calcium & Phosphorus Deficient Mineral Mixed based on AIN-76 基于AIN-76的钙磷缺乏矿物混合物
TD.98057 Calcium & Phosphorus Deficient Mineral Mixed based on AIN-93 基于AIN-93的钙磷缺乏矿物混合物

Harlan TD.95027低钙饲料(0.4%P)

Harlan TD.95027低钙饲料(0.4%P)
Harlan货号:TD.95027
英文名称:Low Calcium Diet (0.4% P)
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Formula                                                                     g/Kg
Casein                                                                    200.0
Cystine                                                                     3.0
Sucrose                                                            342.188
Corn Starch                                                         320.0
Soybean Oil                                                          60.0
Cellulose                                                              40.0
Mineral Mix, Ca-P Deficient (79055)                    13.37
Potassium Phosphate, monobasic                     11.43
Vitamin Mix, Teklad (40060)                                10.0
Ethoxyquin, antioxidant                                       0.012
Key Features
+ Purified Diet
+ Calcium
+ Phosphorus
Key Planning Information
+ Products are made fresh to order
+Store product at 4°C or lower
+Use within 6 months (applicable to most diets)
+Box labeled with product name, manufacturing date, and lot number
+ Replace diet at minimum once per week More frequent replacement may be advised
+ Lead time:
· 2 weeks non-irradiated
· 4 weeks irradiated
上海金畔生物科技有限公司(www.jinpanbio.com)提供生命科学研究领域系列产品,包括生化试剂、诊断试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料;修饰性PEG(Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG);Sigma、Amresco、TCI、MP bio生化试剂;WAKO日本和光纯药、日本关东化学Kanto试剂、日本三菱、日本柴田科学SIBATA;Megazyme食品分析检测试剂盒、日本共立理化学;Research diets、Harlan饲料、Bio-Serv、日本CLEA Japan品牌的动物饲料;Oxoid、Nissui日水、日本荣研、BD difco、Himedia品牌微生物培养基;免疫诊断试剂包括:Bethyl抗体;Biolegend流式抗体、Abcam、CST、Santa Cruz抗体;Roche、TOYOBO、NEB品牌的酶;中检所、TRC、药典USP、EP、Reagecon标准品;耗材和仪器包括Whatman、日本Advantec滤膜、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Wheaton瓶子、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
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Harlan 动脉粥样硬化(胆固醇、脂肪、胆酸盐) 饲料Atherogenic

Harlan 动脉粥样硬化(胆固醇、脂肪、胆酸盐) 饲料Atherogenic
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Harlan 动脉粥样硬化(胆固醇、脂肪、胆酸盐) 饲料Atherogenic
Atherogenic

Research use Key dietary features Examples
“Western” purified atherogenic diet
Accelerated hypercholesterolemia and plaque formation in genetically modified models such as Apoe and Ldlr deficient mice.
Used for diet induced obesity in a variety of rodent models.
High fat diet (20 – 23% by weight; 40 – 45% kcal from fat)
Saturated fatty acids (SFA >60% of total fatty acids)
Milkfat/butterfat
Sucrose (34% by weight)
Cholesterol (0.2% total)
TD.88137
TD.10885
“Western” purified atherogenic diet with added cholesterol and cholate source*
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.
Will not promote obesity.
High fat diet (15 – 20% by weight; 34 – 45% kcal from fat)
Saturated fatty acids (SFA >55% of total fatty acids)
Milkfat/butterfat, cocoa butter
Sucrose (30-50% by weight)
Cholesterol (1 – 1.25%)
Cholate Source (0.5%)*
TD.02028
TD.09237
Hybrid high fat diets with added cholesterol and cholate source*
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.
Will not promote obesity.
Also used for lithogenic (gallstone) rodent studies.
75% rodent breeder diet; 25% purified ingredients
High fat (~15% by weight; 37% kcal from fat)
Saturated fatty acids (SFA >45% of total fatty acids)
Cholesterol (1.25%)
Cholate source (0.5%)*
TD.88051
TD.90221
Standard diets with added cholesterol
Induce hypercholesterolemia in genetically modified and wild type models without promoting obesity. Standard, grain-based rodent diet
Minimal/moderate phytoestrogen diets recommended
Cholesterol (1 – 4%)
TD.120097
TD.07841
TD.01383

*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis. However, if including a cholate source is not desired for your research, diets without cholate are available.
*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis.However, if including a cholate source is not desired for your research, diets without cholate are available.

在实验动物模型中,饮食是诱导或加速动脉粥样硬化的有用工具。用于诱发啮齿类动物动脉粥样硬化的主要饮食特征因研究模型、所需终点和喂养时间的不同而不同。尽管动脉粥样硬化饮食的配方在不断发展,但文献中详细描述的备选方案概述如下。有关每个饮食选项和文献参考的更多信息,请参见节目表后面的可扩展选项卡。
研究用途 主要饮食特征 实例
“西方”纯正致动脉粥样硬化饮食
加速高胆固醇血症和斑块形成的转基因模型,如APOE和Ldlr缺乏的小鼠。
用于饮食诱导肥胖的各种啮齿动物模型。
  • 高脂饮食(按体重计算占20-23%;脂肪占40-45%)
  • 饱和脂肪酸(SFA>总脂肪酸的60%)
  • 乳脂/乳脂
  • 蔗糖(按重量计占34%)
  • 胆固醇(总数0.2%)
TD.88137
TD.10885
添加胆固醇和胆酸来源的“西方”纯动脉粥样硬化饮食*
在野生型小鼠和大鼠中诱导高胆固醇血症和轻度动脉粥样硬化(泡沫细胞、脂肪条纹)。
不会助长肥胖。
  • 高脂饮食(体重15-20%;脂肪34-45千卡)
  • 饱和脂肪酸(SFA>总脂肪酸的55%)
  • 乳脂/黄油、可可脂
  • 蔗糖(重量占30%-50%)
  • 胆固醇(1-1.25%)
  • 巧克力来源(0.5%)*
TD.02028
TD.09237
添加胆固醇和胆酸盐的混合高脂饮食*
在野生型小鼠和大鼠中诱导高胆固醇血症和轻度动脉粥样硬化(泡沫细胞、脂肪条纹)。
不会助长肥胖。
也用于造石(胆石)啮齿动物的研究。
  • 75%的啮齿动物饲养员;25%的纯化成分
  • 高脂肪(体重约15%;脂肪37%千卡)
  • 饱和脂肪酸(SFA>总脂肪酸的45%)
  • 胆固醇(1.25%)
  • 巧克力源(0.5%)*
TD.88051
TD.90221
添加胆固醇的标准饮食
在转基因和野生型模型中诱导高胆固醇血症而不促进肥胖。
  • 标准的、以谷物为基础的啮齿动物饮食
  • 最小/中度植物雌激素饮食建议
  • 胆固醇(1-4%)
TD.120097
TD.07841
TD.01383

*胆酸钠或胆酸有助胆固醇和脂肪的吸收,并可透过胆汁酸合成减少胆固醇的排出。然而,如果你的研究不想包括胆酸盐的来源,没有胆酸盐的饮食是可用的。

“Western” purified atherogenic diet
“Western” style diets are fed to genetically-modified cardiovascular models, such as Apoe and Ldlr deficient mice, to accelerate and enhance hypercholesterolemia and plaque formation and to elicit phenotypes commonly associated with metabolic syndrome.Within the atherogenic literature, a “Western” diet typically is described as a purified rodent diet with 20-23% milkfat/butterfat, 0.2% total cholesterol, and 34% sucrose by weight.TD.88137is an example of a “Western” style diet that was originally designed to characterize and enhance atherosclerosis development in a newly generated Apoe-deficient mouse model.Contact us for more information about “Western” style diets, modifications, or possible control diets.
Examples:
TD.88137Adjusted calories diet (42% from fat, 0.2% total cholesterol)
TD.1088545% fat Kcal diet (0.2% total cholesterol)
Research use:
Accelerated hypercholesterolemia and plaque formation in genetically-modified models, such as Apoe and Ldlr deficient mice.
Used for diet-induced obesity in a variety of rodent models.
Key dietary features:
High Fat Diet (20-23% by weight; 40 – 45% kcal from fat)
Saturated fatty acids (SFA >60% of total fatty acids)
Milkfat/butterfat
Sucrose (34% by weight)
Cholesterol (0.2% total)
References:
1.Febbraio, M., et al., Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice.J Clin Invest, 2000.105(8): p.1049-56.
2.Huszar, D., et al., Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1.Arterioscler Thromb Vasc Biol, 2000.20(4): p.1068-73.
3.Nakashima, Y., et al., ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.Arterioscler Thromb, 1994.14(1): p.133-40.
4.Nakashima, Y., et al., Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse.Arterioscler Thromb Vasc Biol, 1998.18(5): p.842-51.
5.Plump, A.S., et al., Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.Cell, 1992.71(2): p.343-53.
6.Towler, D.A., et al., Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice.J Biol Chem, 1998.273(46): p.30427-34.
7,Tsuchiya, K., et al., FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis.Cell Metab, 2012.15(3): p.372-81.
“Western” purified atherogenic diet with added cholesterol and cholate source*
Wild type mice and rats generally are resistant to atherosclerosis, requiring more extreme dietary manipulation to modify lipoprotein profiles and develop mild atherosclerosis (foam cells, fatty streaks).Modern formulations are made completely of purified ingredients because this more refined approach has been reported to decrease the incidence of gallstones and liver damage associated with less refined and more traditional dietary approaches.To induce mild atherosclerosis in wild type animals, the “Western” purified diet can be modified to increase cholesterol (1-1.25%) and add a bile salt such as sodium cholate or cholic acid.Contact us for more information, modifications, or possible control diets.
Examples of purified high fat diets with added cholesterol and cholate source*:
TD.0202821% milkfat (1.25% cholesterol, 0.5% cholic acid)
TD.0923715% milkfat diet (1% cholesterol, 0.5% sodium cholate)
Examples of purified high fat diets with added cholesterol (without cholate source):
TD.9612121% milkfat (1.25% cholesterol)
Research Use:
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) primarily in wild type mice and rats.
Will not promote obesity.
Key dietary features:
High fat diet (15-20% by weight; 34 – 45% kcal from fat)
Saturated fatty acids (SFA >55% of total fatty acids)
Milkfat/butterfat, cocoa butter
Sucrose (30-50% by weight)
Cholesterol (1 – 1.25%)
Cholate source (0.5%)*
References:
1.Bernal, C., et al., Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis.J Nutr Biochem, 2013.24(11): p.1870-81.
2.Gao, Q., et al., Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase.Inflamm Bowel Dis, 2010.16(12): p.2043-54.
3.Lichtman, A.H., et al., Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate.Arterioscler Thromb Vasc Biol, 1999.19(8): p.1938-44.
4.Marcondes, M.C., et al., Effects of chronic mental stress and atherogenic diet on the immune inflammatory environment in mouse aorta.Brain Behav Immun, 2011.25(8): p.1649-57.
5.Nishina, P.M., et al., Effects of dietary fats from animal and plant sources on diet-induced fatty streak lesions in C57BL/6J mice.J Lipid Res, 1993.34(8): p.1413-22.
6.Nishina, P.M., et al., Atherosclerosis and plasma and liver lipids in nine inbred strains of mice.Lipids, 1993.28(7): p.599-605.
7.Yue, P., et al., Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice.PLoS One, 2010.5(3): p.e9906.
8.Nishina, P.M., J. Verstuyft, and B. Paigen, Synthetic low and high fat diets for the study of atherosclerosis in the mouse.J Lipid Res, 1990.31(5): p.859-69.
*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis.However, if including a cholate source is not desired for your research, diets without cholate are available.SeeTD.96121for a purified diet andTD.94059for a hybrid diet.Contact us for additional options.
Hybrid high fat diets with added cholesterol and cholate source*
Beverly Paigen and colleagues first characterized atherosclerosis development in C57BL/6 mice by feeding a hybrid atherogenic diet.The hybrid diet was created by mixing a natural ingredient mouse diet in a 3:1 ratio with a concentrated purified diet (containing 5% cholesterol and 2% sodium cholate; referred to as Thomas-Hartroft diet).The resulting mixture recreated inTD.88051/TD.90221(same formula) contains ~15.8% fat, 1.25% cholesterol, and 0.5% sodium cholate.This group later compared the hybrid atherogenic diet approach to the more modern “western” purified atherogenic diet with added cholesterol and cholate and found that the hybrid atherogenic diet induced more gallstones and liver damage.Hybrid diets contain a variety of unrefined ingredients that may modify lipid metabolism and atherogenesis and do not allow for precise control of ingredients and nutrients for the study of chronic diseases.Although more refined diets have been developed, hybrid atherogenic diets are still popular for inducing mild atherosclerosis and gallstones in wild type mice and rats.Contact us for more information, modifications, or possible control diets.
Examples of hybrid high-fat diets with added cholesterol and cholate source*:
TD.88051andTD.90221(same formula) are Teklad product codes for hybrid atherogenic diets
Example of hybrid high-fat diet with added cholesterol (without cholate source):
TD.94059
Research Use:
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) primarily in wild type mice and rats.
Will not promote obesity.
Also used for lithogenic (gallstone) rodent studies.
Key dietary features:
75% rodent breeder diet; 25% purified ingredients
High fat (~15% by weight; 37% kcal from fat)
Saturated fatty acids (SFA >45% of total fatty acids)
Cholesterol (1.25%)
Cholate source (0.5%)*
References:
1.Nishina, P.M., J. Verstuyft, and B. Paigen, Synthetic low and high fat diets for the study of atherosclerosis in the mouse.J Lipid Res, 1990.31(5): p.859-69.
2.Clee, S.M., et al., Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis.J Lipid Res, 2000.41(4): p.521-31.
3.George, J., et al., Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein-65.Arterioscler Thromb Vasc Biol, 1999.19(3): p.505-10.
4.Miyake, J.H., et al., Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice.Arterioscler Thromb Vasc Biol, 2002.22(1): p.121-6.
5.Paigen, B., et al., Quantitative assessment of atherosclerotic lesions in mice.Atherosclerosis, 1987.68(3): p.231-40.
6.Schreyer, S.A., D.L. Wilson, and R.C. LeBoeuf, C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis.Atherosclerosis, 1998.136(1): p.17-24.
7.Vergnes, L., et al., Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression.J Biol Chem, 2003.278(44): p.42774-84.
*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis.However, if including a cholate source is not desired for your research, diets without cholate are available.SeeTD.96121for a purified diet andTD.94059for a hybrid diet.Contact us for additional options.
Standard diets with added cholesterol
Standard, natural ingredient diets with cholesterol added are fed to induce hypercholesterolemia.Various levels of cholesterol, fat, and/or bile salts can be added to one of the numerous standard rodent diets stocked by Envigo Teklad.For many applications, adding these components to Envigo’s minimal-to-moderate phytoestrogen global rodent diets is recommended.Our minimal phytoestrogen global rodent diets are soybean meal free, limiting the effect of phytoestrogens on your research outcomes.Soybean meal, a common dietary source of phytoestrogens, has been shown to decrease aortic fatty streak development and modify plasma cholesterol, which may reduce the risk of developing atherosclerosis.Limiting dietary soybean meal may reduce confounding variables within your dietary-induced atherosclerosis model.Contact a nutritionist to discuss additional diet options.
Examples of minimal and moderate phytoestrogen rodent diets with added cholesterol:
TD.1200971% cholesterol diet (2020 – minimal phytoestrogens)
TD.078412% cholesterol diet (2016 – minimal phytoestrogens)
TD.013832% cholesterol (2018 – Moderate phytoestrogens)
Research use:
Induce hypercholesterolemia in genetically-modified and wild type models without promoting obesity.
Key dietary features:
Standard, grain-based rodent diet
Minimal/moderate phytoestrogen diets recommended
Cholesterol (1 – 4%)
References:
1.Belch, J.J., et al., Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo.Microvasc Res, 2013.85: p.86-92.
2.Hartvigsen, K., et al., A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome.Arterioscler Thromb Vasc Biol, 2007.27(4): p.878-85.
Diets for additional animal models of atherosclerosis
Rabbits, hamsters, and swine are common models of atherosclerosis.Contact a nutritionist for information and formula examples.Seerabbit, swine and other speciesfor information and formula examples.
“西方”纯正致动脉粥样硬化饮食

“西式”饮食被喂给基因修饰的心血管模型,如APOE和Ldlr缺乏的小鼠,以加速和促进高胆固醇血症和斑块形成,并引出通常与代谢综合征相关的表型。在动脉粥样硬化的文献中,“西方”饮食通常被描述为含有20-23%乳脂/蝴蝶脂肪、0.2%总胆固醇和34%蔗糖的纯啮齿动物饮食。TD.88137这是一种“西式”饮食的例子,最初的目的是在一种新生成的APOE缺陷小鼠模型中描述和促进动脉粥样硬化的发展。联系我们,以获得更多关于“西方”风格的饮食,修改,或可能的控制饮食。
例子:

  • TD.88137调整卡路里饮食(42%来自脂肪,0.2%总胆固醇)
  • TD.1088545%脂肪KCAL饮食(总胆固醇0.2%)

研究用途:
加速高胆固醇血症和斑块形成的转基因模型,如APOE和Ldlr缺乏的小鼠。
用于饮食诱导肥胖的各种啮齿动物模型。
主要饮食特征:

  • 高脂肪饮食(按体重计算占20-23%;脂肪占40-45%)
  • 饱和脂肪酸(SFA>总脂肪酸的60%)
  • 乳脂/乳脂
  • 蔗糖(按重量计占34%)
  • 胆固醇(总数0.2%)
野生型小鼠和大鼠一般对动脉粥样硬化有抵抗力,需要更极端的饮食操作来改变脂蛋白谱,形成轻度动脉粥样硬化(泡沫细胞、脂肪条纹)。现代配方完全是由纯化成分制成的,因为据报道,这种更精细的方法可以减少较少精制和较传统饮食方法引起的胆结石和肝脏损害的发生率。为了在野生型动物中诱导轻度动脉粥样硬化,可对“西方”纯化饲料进行改良,以提高胆固醇(1-1.25%),并添加胆酸钠或胆酸等胆盐。联系我们获得更多的信息,修改,或可能的控制饮食。
添加胆固醇和胆酸盐来源的纯化高脂饮食的例子*:

  • TD.0202821%乳脂(1.25%胆固醇,0.5%胆酸)
  • TD.0923715%乳脂饮食(1%胆固醇,0.5%胆酸钠)

添加胆固醇的纯化高脂饮食的例子(没有胆酸来源):

  • TD.9612121%乳脂(1.25%胆固醇)

研究用途:
主要在野生型小鼠和大鼠诱发高胆固醇血症和轻度动脉粥样硬化(泡沫细胞、脂肪条纹)。
不会助长肥胖。
主要饮食特征:

  • 高脂饮食(体重15-20%;脂肪34-45千卡)
  • 饱和脂肪酸(SFA>总脂肪酸的55%)
  • 乳脂/黄油、可可脂
  • 蔗糖(重量占30%-50%)
  • 胆固醇(1-1.25%)
  • 巧克力源(0.5%)*

*胆酸钠或胆酸有助胆固醇和脂肪的吸收,并可透过胆汁酸合成减少胆固醇的排出。然而,如果你的研究不想包括胆酸盐的来源,没有胆酸盐的饮食是可用的。看见TD.96121为了纯正的饮食TD.94059混合饮食。请与我们联系,了解其他选项。

贝弗利·派根和他的同事首先通过喂养一种混合性动脉粥样硬化饮食来描述C57BL/6小鼠动脉粥样硬化的发展。这种混合饲料是通过将一种天然成分的老鼠饲料按3:1的比例与浓缩的纯化饲料(含5%胆固醇和2%胆酸钠;称为Thoms-Hartroft饮食)混合而成的。产生的混合物在TD.88051/TD.90221(同配方)含有~15.8%脂肪、1.25%胆固醇和0.5%胆酸钠。这组人后来将混合动脉粥样硬化饮食方法与更现代的“西方”纯化动脉粥样硬化饮食方法进行了比较,并添加了胆固醇和胆酸盐,发现混合动脉粥样硬化饮食会导致更多的胆结石和肝脏损伤。混合饮食含有多种未精制的成分,这些成分可能会改变血脂代谢和动脉粥样硬化的发生,并且不允许对成分和营养物进行精确控制,以用于慢性病的研究。虽然已经开发出了更精细的饮食,但混合动脉粥样硬化饮食仍然是野生型小鼠和大鼠诱发轻度动脉粥样硬化和胆结石的流行食品。联系我们获得更多的信息,修改,或可能的控制饮食。
添加胆固醇和胆酸盐的混合高脂饮食实例*:

  • TD.88051和TD.90221(相同的配方)是特克拉德混合动脉粥样硬化饮食的产品代码。

添加胆固醇的混合高脂饮食的例子(没有胆酸来源):

  • TD.94059

研究用途:
主要在野生型小鼠和大鼠诱发高胆固醇血症和轻度动脉粥样硬化(泡沫细胞、脂肪条纹)。
不会助长肥胖。
也用于造石(胆石)啮齿动物的研究。
主要饮食特征:

  • 75%的啮齿动物饲养员;25%的纯化成分
  • 高脂肪(体重约15%;脂肪37%千卡)
  • 饱和脂肪酸(SFA>总脂肪酸的45%)
  • 胆固醇(1.25%)
  • 巧克力源(0.5%)*

*胆酸钠或胆酸有助胆固醇和脂肪的吸收,并可透过胆汁酸合成减少胆固醇的排出。然而,如果你的研究不想包括胆酸盐的来源,没有胆酸盐的饮食是可用的。看见TD.96121为了纯正的饮食TD.94059混合饮食。请与我们联系,了解其他选项。

标准的,添加胆固醇的天然成分饮食是用来诱导高胆固醇血症的。不同水平的胆固醇,脂肪和/或胆汁酸盐可以添加到众多的标准啮齿动物饮食之一,由EnvigoTeclad。在许多应用中,建议将这些成分添加到Envigo的最小到中等植物雌激素的全球啮齿动物饮食中。我们最小的植物雌激素全球啮齿动物饮食是不含豆粕的,限制了植物雌激素对你的研究结果的影响。豆粕是一种常见的植物雌激素来源,它可以减少主动脉脂肪条纹的发育,改善血浆胆固醇,从而降低动脉粥样硬化的风险。限制饮食豆粕可能会减少饮食诱导动脉粥样硬化模型中的混杂变量。联系营养学家讨论其他饮食选择。
添加胆固醇的最小和中度植物雌激素啮齿动物饮食的例子:

  • TD.120097  1%胆固醇饮食(2020年-最小植物雌激素)
  • TD.07841  2%胆固醇饮食(2016年-最小植物雌激素)
  • TD.01383  2%胆固醇(2018年-中度植物雌激素)

研究用途:
在转基因和野生型模型中诱导高胆固醇血症而不促进肥胖。
主要饮食特征:

  • 标准的、以谷物为基础的啮齿动物饮食
  • 最小/中度植物雌激素饮食建议
  • 胆固醇(1-4%)
兔子、仓鼠和猪是动脉粥样硬化的常见模型。请与营养师联系,了解有关信息和公式示例。看见兔子、猪和其他物种有关信息和公式示例。

Harlan蛋白质调节饲料 Protein adjusted diets

Harlan蛋白质调节饲料 Protein adjusted diets
Teklad diet, bedding and enrichment + Teklad laboratory animal diets + Custom research diets + Protein adjusted diets
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Harlan蛋白质调节饲料 Protein adjusted diets
Protein adjusted diets | Envigo
A few protein adjusted formulas are shown below. Please contact us for additional formulas of this nature or for more information about altering the protein type or content of a diet.
Formula examples:
TD.93328      “Protein free” diet
TD.90016      6% Protein diet
TD.91352       20% Protein diet
TD.90018      40% Protein diet
These diet examples are from a series of diets with the following features: casein-based, isocaloric (3.8 kcal/g) and matched for fat (5.5%), calcium (0.7%), and phosphorus (0.54%).  There are other diets available from this series of diets, as well as other unique protein adjusted diets.
Casein is the most widely used refined protein source, but it is also possible to use other refined protein sources, such as “vitamin-free” test casein (alcohol extracted), lactalbumin, isolated soy protein, and egg white solids. These particular protein sources are usually used to achieve a specific research objective, rather than for routine use. For instance, vitamin-free test casein is most appropriately used in vitamin deficient diets, and egg white solids is most suitable for zinc or biotin deficient diets.
Adjusted protein diets usually range from “protein-free” (trace) to 60% protein, depending on the research.
一些蛋白质调整的公式如下所示。请与我们联系,以获得更多的这种性质的配方,或更多有关改变蛋白质类型或饮食内容的信息。
公式示例:
TD.93328“无蛋白质”饮食
TD.90016  6%蛋白质饮食
TD.91352  20%蛋白质饮食
TD.90018  40%蛋白质饮食
这些饮食的例子来自一系列的饮食,有以下特点:酪蛋白为基础,等热量(3.8千卡/克),与脂肪(5.5%),钙(0.7%)和磷(0.54%)匹配。从这一系列的饮食中可以得到其他的饮食,以及其他独特的蛋白质调整的饮食。
酪蛋白是最广泛使用的精制蛋白质来源,但也可以使用其他精制蛋白质来源,如“无维生素”测试酪蛋白(醇提),乳清蛋白,分离大豆蛋白和蛋清固体。这些特定的蛋白质来源通常用于实现特定的研究目标,而不是用于常规用途。例如,无维生素测试酪蛋白最适合用于缺乏维生素的饮食,而蛋清固体最适合于锌或生物素缺乏的饮食。
根据研究结果,调整后的蛋白质饮食通常从“无蛋白质”(微量)到60%的蛋白质。
上海金畔生物科技有限公司(www.jinpanbio.com)提供生命科学研究领域系列产品,包括生化试剂、诊断试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料;修饰性PEG(Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG);Sigma、Amresco、TCI、MP bio生化试剂;WAKO日本和光纯药、日本关东化学Kanto试剂、日本三菱、日本柴田科学SIBATA;Megazyme食品分析检测试剂盒、日本共立理化学;Research diets、Harlan饲料、Bio-Serv、日本CLEA Japan品牌的动物饲料;Oxoid、Nissui日水、日本荣研、BD difco、Himedia品牌微生物培养基;免疫诊断试剂包括:Bethyl抗体;Biolegend流式抗体、Abcam、CST、Santa Cruz抗体;Roche、TOYOBO、NEB品牌的酶;中检所、TRC、药典USP、EP、Reagecon标准品;耗材和仪器包括Whatman、日本Advantec滤膜、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Wheaton瓶子、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
上海金畔生物科技有限公司
服务热线:18301939375   QQ:3258089810    3259632176
Email:  info@jinpanbio.com
官网:http://www.jinpanbio.com

Harlan 维生素调整饲料 Vitamin adjusted diets

Harlan 维生素调整饲料 Vitamin adjusted diets
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
A few vitamin adjusted formulas are shown below. Please contact us for additional formulas of this nature or for more information about altering the vitamin profile of a diet, and please read below to learn more.
Formula Examples:
TD.86143 Vitamin A deficient diet
TD.89123 Vitamin D deficient diet
TD.88163 Vitamin E deficient diet
TD.95247 Folic acid deficient diet
Most vitamin deficient diets use vitamin-free test casein (VFT casein) as the protein source. VFT casein is casein that has been extracted with denatured alcohol to reduce the fat content from about 1% to 0.1%. In the process the content of a number of vitamins (present at low or trace levels in casein) is further reduced, making this an ideal protein source for these types of diets. Envigo produces our own VFT in-house, and we also offer this as an ingredient for those mixing their own diets.
From this vitamin deficient base, various levels of vitamins can be added back. Many formulas adjust multiple vitamins, and other nutrients.
If use of an intact protein source is not advisable, an amino acid defined diet can be used.
一些维生素调整公式如下所示。请与我们联系,以获得更多的这种性质的配方或更多的信息,以改变维生素的饮食概况,并请阅读下面来了解更多。
公式示例:
TD.86143维生素A缺乏饮食
TD.89123维生素D缺乏饮食
TD.88163维生素E缺乏饮食
TD.95247叶酸缺乏饮食
大多数缺乏维生素的饮食使用无维生素的测试酪蛋白(VFT酪蛋白)作为蛋白质来源。VFT酪蛋白是用变性醇提取的酪蛋白,使脂肪含量从1%左右降至0.1%左右。在这个过程中,一些维生素的含量(在低水平或微量的酪蛋白)被进一步减少,使之成为这些类型的饮食的理想的蛋白质来源。Envigo生产我们自己的VFT内部产品,我们也为那些混合他们自己的饮食的人提供这种材料。
从这个缺乏维生素的基础,不同水平的维生素可以补充回来。许多配方调整多种维生素和其他营养。
如果使用完整的蛋白质源是不可取的,氨基酸限定饮食可以使用。
上海金畔生物科技有限公司(www.jinpanbio.com)提供生命科学研究领域系列产品,包括生化试剂、诊断试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料;修饰性PEG(Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG);Sigma、Amresco、TCI、MP bio生化试剂;WAKO日本和光纯药、日本关东化学Kanto试剂、日本三菱、日本柴田科学SIBATA;Megazyme食品分析检测试剂盒、日本共立理化学;Research diets、Harlan饲料、Bio-Serv、日本CLEA Japan品牌的动物饲料;Oxoid、Nissui日水、日本荣研、BD difco、Himedia品牌微生物培养基;免疫诊断试剂包括:Bethyl抗体;Biolegend流式抗体、Abcam、CST、Santa Cruz抗体;Roche、TOYOBO、NEB品牌的酶;中检所、TRC、药典USP、EP、Reagecon标准品;耗材和仪器包括Whatman、日本Advantec滤膜、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Wheaton瓶子、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
上海金畔生物科技有限公司
服务热线:18301939375   QQ:3258089810    3259632176
Email:  info@jinpanbio.com
官网:http://www.jinpanbio.com

Harlan矿物质调节饲料Mineral adjusted diets

Harlan矿物质调节饲料Mineral adjusted diets
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Mineral adjusted diets
A few mineral adjusted formulas are shown below. Please contact us for additional formulas of this nature or for more information about altering the mineral profile of a diet. Read below for more information.
Formula examples:
TD.80396      Iron deficient diet
TD.85419      Zinc deficient diet
TD.88239      Potassium deficient diet
TD.95027      Low calcium diet (0.4% P)
TD.96348      Diet (20% lactose, 2% Ca, 1.25% P)
TD.92163      Selenium deficient diet
TD.95125      Iodine deficient (0.15% PTU)
Unique protein ingredients may be necessary to minimize background levels of certain minerals. Other steps taken to minimize background mineral contamination include the use of reagent grade minerals when necessary or omission of certain ingredients. Specialized mineral premixes may be used in these diets, or minerals are added individually to the diet in order to control the level of specific minerals.
With the exception of sodium, it is necessary to use refined ingredients to achieve the lowest possible levels of minerals in a diet.
From this mineral deficient base, various levels of minerals can be added back. Some formulas adjust multiple minerals, and other related nutrients.
Contact us to discuss other possibilities for the minerals listed above, and for those minerals not listed here.
一些矿物调整公式如下所示。请与我们联系,以获得更多的这种性质的配方,或更多的信息,改变矿物质的饮食。有关更多信息,请阅读下面。
公式示例:
TD.80396缺铁饮食
TD.85419缺锌饮食
TD.88239缺钾饮食
TD.95027低钙饮食(0.4%P)
TD.96348日粮(20%乳糖,2%钙,1.25%P)
TD.92163缺硒饮食
TD.95125缺碘(0.15%PTU)
独特的蛋白质成分可能是必要的,以尽量减少某些矿物质的背景水平。为尽量减少背景矿物污染而采取的其他步骤包括在必要时使用试剂级矿物或遗漏某些成分。在这些饮食中可以使用特殊的矿物预混料,也可以在饮食中单独添加矿物质,以控制特定矿物质的含量。
除钠外,必须使用精制成分,以达到饮食中矿物质含量尽可能低的水平。
从这种矿物缺乏的基础,不同水平的矿物可以补充回来。一些配方调整多种矿物质和其他相关营养素。
上海金畔生物科技有限公司(www.jinpanbio.com)提供生命科学研究领域系列产品,包括生化试剂、诊断试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料;修饰性PEG(Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG);Sigma、Amresco、TCI、MP bio生化试剂;WAKO日本和光纯药、日本关东化学Kanto试剂、日本三菱、日本柴田科学SIBATA;Megazyme食品分析检测试剂盒、日本共立理化学;Research diets、Harlan饲料、Bio-Serv、日本CLEA Japan品牌的动物饲料;Oxoid、Nissui日水、日本荣研、BD difco、Himedia品牌微生物培养基;免疫诊断试剂包括:Bethyl抗体;Biolegend流式抗体、Abcam、CST、Santa Cruz抗体;Roche、TOYOBO、NEB品牌的酶;中检所、TRC、药典USP、EP、Reagecon标准品;耗材和仪器包括Whatman、日本Advantec滤膜、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Wheaton瓶子、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
上海金畔生物科技有限公司
服务热线:18301939375   QQ:3258089810    3259632176
Email:  info@jinpanbio.com
官网:http://www.jinpanbio.com

Harlan teklad 碳水化合物调节饲料Carbohydrate adjusted

Harlan teklad 碳水化合物调节饲料Carbohydrate adjusted
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Harlan teklad 碳水化合物调节饲料Carbohydrate adjusted
Carbohydrate adjusted
A few carbohydrate adjusted formulas are shown below. Please contact us for additional formulas of this nature or for more information about altering the carbohydrate profile of a diet.
Formula examples:
TD.89247      60% Fructose diet
TD.86489      Diet with adjusted sucrose/cornstarch
TD.96348      Diet (20% lactose, 2% Ca, 1.25% P)
TD.98090      70% Carbohydrate diet
TD.96355      Ketogenic diet (almost no carbohydrate)
Carbohydrates often make up the majority (by weight and % kcal) of custom research diets, with the exception of higher fat diets. Commonly used carbohydrate sources include sucrose, cornstarch and maltodextrin. Other sources include fructose, dextrose (glucose), dextrin, and lactose. Maltodextrin is enzymatically derived from cornstarch to have shorter glucose polymers and is helpful in pelleting high fat diets and in diets where cornstarch exceeds sucrose.
Sucrose is a part of most formulas, often making up 10% of the diet or more. This likely adds to the palatability of the diet. The carbohydrate profile of a diet can be manipulated, although some mixtures may not pellet. There are also diets with very little carbohydrate, thus containing high amounts of fat and/or protein.
Cellulose (fiber) is part of many formulas and while not required by rodents, is considered beneficial. It can also be used to make formulas with differing macronutrient profiles isocaloric.
一些碳水化合物调整公式如下所示。请与我们联系,以获得更多的这种性质的配方,或更多有关改变饮食的碳水化合物的信息。
公式示例:
TD.8924760%果糖饮食
TD.86489调整蔗糖/玉米淀粉的饮食
TD.96348日粮(20%乳糖,2%钙,1.25%P)
TD.9809070%碳水化合物饮食
TD.96355生酮饮食(几乎没有碳水化合物)
碳水化合物往往占大多数(按体重和%千卡)的习惯研究饮食,除了高脂肪饮食。常用的碳水化合物来源包括蔗糖、玉米淀粉和麦芽糊精。其他来源包括果糖、葡萄糖、糊精和乳糖。麦芽糊精是从玉米淀粉中得到的酶解物,它含有较短的葡萄糖聚合物,有助于高脂饲料的颗粒化和玉米淀粉超过蔗糖的饮食。
蔗糖是大多数配方的一部分,通常占饮食的10%或更多。这可能会增加饮食的适口性。饮食中的碳水化合物可以被操纵,尽管有些混合物可能不是颗粒。也有很少碳水化合物的饮食,因此含有大量的脂肪和/或蛋白质。
纤维素(纤维)是许多配方的一部分,虽然不是啮齿动物所必需的,但被认为是有益的。它也可以用来制作不同的黄金分割配方等热量。
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Harlan teklad品牌饲料分类

Harlan teklad品牌饲料分类
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Teklad diet, bedding and enrichment + Teklad laboratory animal diets + Custom research diets
Custom diets are developed for a specific purpose and benefit from your input and our expertise
Determining the most appropriate diet for your research model can be challenging, but we are here to help. With more than 20,000 unique formulas in our database attained over 40 years, Envigo nutritionists have vast experience to draw upon. To meet the progressive demands of science and to serve you better, we continually add to our database as we acquire new knowledge.
Common uses for custom diets include:
Control Nutrients
Vitamin or mineral adjusted
Protein or amino acid adjusted
Lipid or fatty acid adjusted
Induce Disease
Atherogenic (cholesterol, fat, cholate)
Diet-induced obesity (40-60% kcal from fat)
High carbohydrate (fructose, sucrose)
NaCl adjusted
Cuprizone demyelination
Dose Animals
Control gene expression – doxycycline or tamoxifen containing diets
Addition of customer-supplied ingredients/compounds
You can select from the wide variety of existing diets, or one designed specifically for your purposes. Either way, we encourage you to contact us for complimentary consultation with our nutritionists.
A small number of representative custom research diet formulas are found on our website. If you are unable to find a product code or formula description cited in a publication, or one used previously by your lab or others, contact us.
定制饮食是为了特定的目的而制定的,并得益于您的投入和我们的专业知识。
为你的研究模式确定最合适的饮食是很有挑战性的,但我们是来帮忙的。在我们的数据库中,已有超过20,000种独特的配方,40多年来,Envigo营养学家有着丰富的经验可供借鉴。为了满足科学进步的需求,并更好地为您服务,我们不断地在我们的数据库中添加新的知识。
习惯饮食的常见用途包括:
控制养分
维生素或矿物调整后
蛋白或氨基酸调整后
脂或脂肪酸调整后
诱发病
动脉粥样硬化(胆固醇、脂肪、胆酸盐)
饮食型肥胖(脂肪40%-60千卡)
高碳水化合物(果糖,蔗糖)
NaCl调节
铜带脱髓鞘
剂量动物
控制基因表达-强力霉素或他莫昔芬含粮
加法客户供应的配料/化合物
你可以从各种各样的现有饮食中选择,或者是专门为你的目的而设计的。无论哪种方式,我们都鼓励您与我们的营养学家进行免费咨询。
Harlan teklad品牌饲料分类

实验动物饲料 Teklad laboratory animal diets
标准天然成分饮食 Standard natural ingredient diets
定制研究饮食 Custom research diets
AIN饮食配方 AIN diet formulas
动脉粥样硬化 Atherogenic
饮食诱导肥胖 Diet induced obesity
脂肪/脂调节 Fat/lipid adjusted
碳水化合物调节 Carbohydrate adjusted
蛋白质调节饮食 Protein adjusted diets
维生素调整饮食 Vitamin adjusted diets
矿物调节饮食 Mineral adjusted diets
盐调节(天然成分) NaCl adjusted (natural ingredient)
氨基酸定义 Amino acid defined
多西环素饮食 Doxycycline diets
他莫昔芬饮食 Tamoxifen diets
客户供应的配料 Customer supplied ingredients
基混合体 Basal mixes
异黄酮调节 Isoflavone adjusted
兔子、猪和其他物种 Rabbit, swine and other species
饮食成分 Diet ingredients
药物饮食 Medicated diets

Harlan MCD饲料 TD.90262 Methionine/Choline Deficient Diet

Harlan MCD饲料 TD.90262 Methionine/Choline Deficient Diet
品牌:Harlan Teklad
货号:TD.90262
英文名称:Methionine/Choline Deficient Diet
别名:MCD饲料
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。

Amino acid defined | Envigo

A few amino acid defined formulas are shown below. This type of diet is used when a diet needs to be deficient in one or more amino acids, or adjustments need to be made to specific amino acid levels.
Formula examples:

  • TD.99366      Amino acid diet
  • TD.90262      Methionine and choline deficient diet
  • TD.00434      Folic acid deficient diet
  • TD.99386      No lysine AA diet

Sometimes this type of diet is used to further reduce the background level of certain vitamins that are found in protein sources such as casein or vitamin-free (alcohol extracted) casein. Some folic acid deficient diets utilize this approach.
The amino acid profile for most amino acid defined diets is based on work by Harper and Rogers (J. Nutr. (1965) 87:267-276) and is not representative of the amino acid profile of an intact protein source such as casein. Other amino acid profiles can be specified. When an amino acid(s) is removed or reduced, isonitrogenous adjustment can be made if required.

Harlan MCD饲料 TD.90262 Methionine/Choline Deficient Diet
 

Harlan TD.09682 高酯饲料 42% Fat Calories Diet (Western, Blue)说明书

Harlan TD.09682 高酯饲料 42% Fat Calories Diet (Western, Blue)说明书
货号:TD.09682
品牌:Harlan
英文名称:42% Fat Calories Diet (Western, Blue)
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Harlan TD.09682 高酯饲料 42% Fat Calories Diet (Western, Blue)说明书
Formula                            g/Kg
Casein                                195.0
DL-Methionine                       3.0
Sucrose                              341.46
Corn Starch                          150.0
Anhydrous Milkfat                      210.0
Cholesterol                            1.5
Cellulose                              49.85
Mineral Mix, AIN-76 (170915)            35.0
Calcium Carbonate                     4.0 +
Vitamin Mix, Teklad (40060)              10.0
Ethoxyquin,                            0.04
Blue Food Color                        0.15
Key Features
+ Purified Diet
+ Atherogenic
+ Modification of TD.88137
+ Color Coded
Key Planning Information
+ Products are made fresh to order
+Store product at 4°C or lower
+Use within 6 months (applicable to most diets)
+ Box labeled with product name, manufacturing date, and lot number
+ Replace diet at minimum once per week  More frequent replacement may be advised
+ Lead time:

  • 2 weeks non-irradiated
  • 4 weeks irradiated

Footnote
Modification of TD.88137 to add blue coloring.
Product Specific Information
+ 1/2″ Pellet or Powder (crumbly)
+ Minimum order 3 Kg
+ Irradiation available upon request
+ Vacuum packaging (1 and 2 Kg)

Harlan肥胖模型高酯饲料 Diet induced obesity

Harlan肥胖模型高酯饲料 Diet induced obesity
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Harlan肥胖高酯模型
Diet induced obesity
 
Purified high fat diets used to induce obesity and obesity-related complications such as diabetes and metabolic syndrome typically have 40-60% of energy derived from fat. The diet tables below summarize relevant diet features for several Teklad custom research diets commonly used in rodent models.
Teklad also creates high-fat diets for other species, including pigs, primates, and dogs. Contact us to discuss the use of these diets or one that better meets your needs.

Commonly-used diet-induced obesity (DIO) Teklad rodent diets with 55-60% of calories from fat
       
Diet features TD.06414 stocked TD.93075 dough TD.07011 pellet
Kcal/g 5.1 4.8
Fat, % Kcal 60 55
Fat Sources,
% by weight
31% lard
3% soybean oil
27.4% vegetable shortening
1.6% corn oil
Fatty acid profile,
% total fat
37% saturated
47% monounsaturated
16% polyunsaturated
28% saturated, 30% trans
28% monounsaturated (cis)
14% polyunsaturated (cis)
Sucrose,
% by weight
12.1 9.6
Notes 60F10S poster data
Compare to D12492
Trans fat
Example modifications TD.08500 coconut oil
TD.09766 milk fat
 
Ingredient matched,
low fat control diets*
TD.06416 (35% sucrose)
TD.08806 (11% sucrose)
TD.93074 (21% sucrose)
TD.120651 (7% sucrose)
References Mouse
Rat
Mouse
Rat

*Control diets can be designed in several ways, depending on what features the researcher wants to modify relative to the high-fat diet. These are just a few examples.

 
Commonly-used diet-induced obesity (DIO) Teklad rodent diets with 40-45% of calories from fat
         
Diet features TD.06415 TD.08811 TD.88137 stocked TD.95217
Kcal/g 4.6 4.7 4.5 4.3
Fat, % Kcal 45 45 42 40
Fat sources,
% by weight
19.5% lard
3% soybean oil
21% milk fat
2% soybean oil
21% milk fat 10.6% vegetable shortening
4% milk fat
4% soybean oil
Fatty acid profile,
% total fat
36% saturated
46% monounsaturated
18% polyunsaturated
61% saturated
31% monounsaturated
8% polyunsaturated
62% saturated
27% monounsaturated
5% polyunsaturated
34% saturated, 18% trans
29% monounsaturated (cis)
19% polyunsaturated (cis)
Sucrose,
% by weight
22.8 36.8 34.5 15.8
Notes Compare to D12451 45F30S poster data “Western Diet”
Cholesterol added
Trans fat
Example modifications TD.110716 milk fat
TD.10670 no dye
TD.130784 lard
TD.120438 no dye
TD.07201 lard
TD.00573 h-coconut oil, no cholesterol
TD.09682 blue dye
TD.07734 green dye
Ingredient matched,
low fat control diets*
TD.06416 (35% sucrose)
TD.110675 (18% sucrose)
TD.120455 (6% sucrose, resistant starch)
TD.120724 (14% sucrose)
TD.05230 (34% sucrose)
TD.08485 (12% sucrose)
TD.06101 (6% sucrose)
References Mouse
Rat
Mouse
Rat
Mouse
Rat
Mouse
Rat

饮食诱导肥胖

用于诱导肥胖和肥胖相关并发症(如糖尿病和代谢综合征)的纯化高脂饮食通常有40-60%的能量来源于脂肪。下面的饮食表总结了一些特克拉德定制研究饮食的相关饮食特征,这些研究饮食通常用于啮齿类动物模型。
泰克乐还为其他物种,包括猪、灵长类动物和狗创造高脂肪饮食。联系我们讨论使用这些饮食或更好地满足您的需要。

通常使用的饮食诱导肥胖(DIO)技术啮齿动物饮食中含有55-60%的热量来自脂肪。
       
饮食特征 TD.06414 备好 TD.93075 面团 TD.07011 球团
千卡/克 5.1 4.8
脂肪,%千卡 60 55
脂肪来源,
按重量计百分比
31%猪油
3%豆油
27.4%蔬菜酥油
1.6%玉米油
脂肪酸谱,
总脂肪百分比
37%饱和
47%单不饱和
16%多不饱和
28%饱和,30%反式
28%单不饱和(顺式)
14%多不饱和
蔗糖
按重量计百分比
12.1 9.6
注记 60F10S海报数据
与D 12492比较
反式脂肪
示例修改 TD.08500椰子油
TD.09766乳脂
 
成分匹配,
低脂控制饮食*
TD.06416(35%蔗糖)
TD.08806(11%蔗糖)
TD.93074(21%蔗糖)
TD.120651(7%蔗糖)
参考文献
大鼠

大鼠

*控制饮食可以通过几种方式来设计,这取决于研究人员相对于高脂肪饮食想要改变什么特征。这些只是几个例子。

 
通常使用的饮食诱导肥胖(DIO)技术啮齿动物饮食中含有40-45%的热量来自脂肪。
         
饮食特征 TD.06415 TD.08811 TD.88137 备好 TD.95217
千卡/克 4.6 4.7 4.5 4.3
脂肪,%千卡 45 45 42 40
脂肪来源,
按重量计百分比
19.5%猪油
3%豆油
21%乳脂
2%豆油
21%乳脂 10.6%蔬菜酥油
4%乳脂
4%豆油
脂肪酸谱,
总脂肪百分比
36%饱和
46%单不饱和
18%多不饱和
61%饱和
31%单不饱和
8%多不饱和
62%饱和
27%单不饱和
5%多不饱和
34%饱和,18%反式
29%单不饱和(顺式)
19%多不饱和
蔗糖
按重量计百分比
22.8 36.8 34.5 15.8
注记 与D 12451比较 45F30S海报数据 “西餐”
添加胆固醇
反式脂肪
示例修改 TD.110716乳脂
TD.10670无染料
TD.130784猪油
TD.120438无染料
TD.07201猪油
TD.00573椰子油,不含胆固醇
TD.09682蓝色染料
TD.07734绿色染料
成分匹配,
低脂控制饮食*
TD.06416(35%蔗糖)
TD.110675(18%蔗糖)
TD.120455(6%蔗糖,抗性淀粉)
TD.120724(14%蔗糖)
TD.05230(34%蔗糖)
TD.08485(12%蔗糖)
TD.06101(6%蔗糖)
参考文献
大鼠

大鼠

大鼠

大鼠

Diets for diet-induced obesity (DIO)
Diets with 55-60% of calories from fat like TD.06414 and TD.93075 are commonly used for inducing obesity in rodents. While considered extreme compared to typical human fat consumption, these diets are effective in initiating rapid weight gain in most rodents. With higher fat content there is less room for carbohydrate, thus the carbohydrate (particularly sucrose) amount is relatively low compared to other obesity inducing diets. If you are interested in high fat and high carbohydrate, look at diets with 40-45% of calories from fat (often referred to as western diets).
As the fat level increases, pellet quality (durability) is often compromised. Some higher fat formulas are available only in non-pelleted form or require specific carbohydrate, maltodextrin, for pelleting. Depending on the fat and carbohydrate sources used, the non-pelleted form could be dense and crumbly, dough-like, or paste-like. Though a little more challenging to work with, non-pelleted diet is still used by many researchers for diet-induced obesity models as these researchers suspect the softer form may enhance obesity development.
Diets with 40-45% of calories from fat, like TD.95217, TD.88137, TD.06415, and TD.08811, represent another popular diet pattern for diet-induced obesity work. These diets have double or triple the amount of sucrose found in higher fat diets. High levels of simple carbohydrate like sucrose and fructose may help to promote hypertriglyceridemia, insulin resistance, and fatty liver. Diets with a pattern of high sucrose and high saturated or trans fat are often referred to as “Western Diets” in obesity and cardiovascular fields. Some “Western Diets” have further modifications to the fatty acid profile or even specific vitamin and minerals adjustments to be even more closely matched to a Western Diet pattern. For specific fatty acid modifications, see examples on our fat/lipid adjusted diets page.
Diets for diet-induced diabetes
Many of the same diets used for inducing obesity in rodents can be used to enhance diabetes related phenotypes like insulin resistance and glucose intolerance. However, fasting hyperglycemia characteristic of diabetes (glucose > 200 mg/dL) is uncommon with a diet only approach. Pre-feeding a high fat diet to induce a certain level of obesity and insulin resistance and then giving low-dose streptozotocin (STZ) may be an effective approach if overt hyperglycemia is desired.
Ingredient matched, low-fat DIO control diets
There are many options with different levels and types of fat in addition to different types of carbohydrate ranging from sucrose (highly refined, simple digestion) to corn starch (refined, but more complex) to resistant starch (refined, but not fully digestible). A very basic purified control diet would be AIN-93M (TD.94048) or AIN-93G (TD.94045). AIN-93 diets have a moderate amount of sucrose at ~10%, and fat is from soybean oil with a healthy fatty acid profile. Additional examples of controls for specific DIO diets can be found in the above tables.
Many researchers choose to compare their high fat fed animals to animals fed a natural ingredient, grain-based diet (also referred to as standard diets or chow). These diets differ in the source and level of nutrients as well as in the presence of non-nutritive factors (such as phytates or phytoestrogens). Depending on what your main comparisons are, it may be suitable to have a grain-based diet as your control/reference group. However, making such comparisons limits inferences to dietary patterns versus a specific dietary component.

harlan teklad官网代理商 动物饲料 动脉粥样硬化 胆固醇和胆酸 TD.88051

harlan teklad官网代理商 动物饲料 动脉粥样硬化 胆固醇和胆酸 TD.88051

harlan teklad官网代理商 动物饲料

动脉粥样硬化

在实验动物模型中,饮食是诱导或加速动脉粥样硬化的有用工具。用于诱发啮齿类动物动脉粥样硬化的主要饮食特征因研究模型、所需终点和喂养时间的不同而不同。尽管动脉粥样硬化饮食的配方在不断发展,但文献中详细描述的备选方案概述如下。有关每个饮食选项和文献参考的更多信息,请参见节目表后面的可扩展选项卡。

研究用途 主要饮食特征 实例
“西方”纯正致动脉粥样硬化饮食
加速高胆固醇血症和斑块形成的转基因模型,如APOE和Ldlr缺乏的小鼠。用于饮食诱导肥胖的各种啮齿动物模型。
  • 高脂饮食(按体重计算占20-23%;脂肪占40-45%)
  • 饱和脂肪酸(SFA>总脂肪酸的60%)
  • 乳脂/乳脂
  • 蔗糖(按重量计占34%)
  • 胆固醇(总数0.2%)
TD.88137
TD.10885
添加胆固醇和胆酸来源的“西方”纯动脉粥样硬化饮食*
在野生型小鼠和大鼠中诱导高胆固醇血症和轻度动脉粥样硬化(泡沫细胞、脂肪条纹)。不会助长肥胖。
  • 高脂饮食(体重15-20%;脂肪34-45千卡)
  • 饱和脂肪酸(SFA>总脂肪酸的55%)
  • 乳脂/黄油、可可脂
  • 蔗糖(重量占30%-50%)
  • 胆固醇(1-1.25%)
  • 巧克力来源(0.5%)*
TD.02028
TD.09237
添加胆固醇和胆酸盐的混合高脂饮食*
在野生型小鼠和大鼠中诱导高胆固醇血症和轻度动脉粥样硬化(泡沫细胞、脂肪条纹)。不会助长肥胖。

也用于造石(胆石)啮齿动物的研究。

  • 75%的啮齿动物饲养员;25%的纯化成分
  • 高脂肪(体重约15%;脂肪37%千卡)
  • 饱和脂肪酸(SFA>总脂肪酸的45%)
  • 胆固醇(1.25%)
  • 巧克力源(0.5%)*
TD.88051
TD.90221
添加胆固醇的标准饮食
在转基因和野生型模型中诱导高胆固醇血症而不促进肥胖。
  • 标准的、以谷物为基础的啮齿动物饮食
  • 最小/中度植物雌激素饮食建议
  • 胆固醇(1-4%)
TD.120097
TD.07841
TD.01383

*胆酸钠或胆酸有助胆固醇和脂肪的吸收,并可透过胆汁酸合成减少胆固醇的排出。然而,如果你的研究不想包括胆酸盐的来源,没有胆酸盐的饮食是可用的。

折叠所有标签

“西式”饮食被喂给基因修饰的心血管模型,如APOE和Ldlr缺乏的小鼠,以加速和促进高胆固醇血症和斑块形成,并引出通常与代谢综合征相关的表型。在动脉粥样硬化的文献中,“西方”饮食通常被描述为含有20-23%乳脂/蝴蝶脂肪、0.2%总胆固醇和34%蔗糖的纯啮齿动物饮食。TD.88137这是一种“西式”饮食的例子,最初的目的是在一种新生成的APOE缺陷小鼠模型中描述和促进动脉粥样硬化的发展。联系我们,以获得更多关于“西方”风格的饮食,修改,或可能的控制饮食。

例子:

  • TD.88137调整卡路里饮食(42%来自脂肪,0.2%总胆固醇)
  • TD.1088545%脂肪KCAL饮食(总胆固醇0.2%)

研究用途:

加速高胆固醇血症和斑块形成的转基因模型,如APOE和Ldlr缺乏的小鼠。

用于饮食诱导肥胖的各种啮齿动物模型。

主要饮食特征:

  • 高脂肪饮食(按体重计算占20-23%;脂肪占40-45%)
  • 饱和脂肪酸(SFA>总脂肪酸的60%)
  • 乳脂/乳脂
  • 蔗糖(按重量计占34%)
  • 胆固醇(总数0.2%)

参考资料:

  1. Febbraio,M,等人,B类清道夫受体CD 36的靶向性破坏对小鼠动脉粥样硬化病变的发展有保护作用。j Clin Investment,2000年。105(8):P。1049-56
  2. Huszar,D,等人,在低密度脂蛋白受体缺乏的小鼠体内增加了低密度脂蛋白胆固醇和动脉粥样硬化,减少了清道夫受体B1的表达。Arteroscler Thromb VASc Biol,2000年。20(4):P。1068-73
  3. Nakashima,Y.,等人,ApoE缺乏的小鼠在整个动脉树形成动脉粥样硬化的各个阶段的病变。Arteroscler Thromb,1994年。14(1):P。133-40
  4. 中岛,Y,等,VCAM-1和ICAM-1在ApoE缺乏的小鼠内皮动脉粥样硬化易发部位上调VCAM-1和ICAM-1的表达。Arteroscler Thromb VASc Biol,1998年。18(5):P。842-51
  5. Plump,A.S.等人,ES细胞同源重组所致载脂蛋白E缺陷小鼠的严重高胆固醇血症和动脉粥样硬化。细胞,1992年。71(2):P。343-53
  6. Towler,D.A.等,饮食诱导的糖尿病激活了低密度脂蛋白受体缺陷小鼠主动脉的成骨基因调控程序。j Biol Chem,1998年。273(46):P。30427-34。
  7. Foxos整合胰岛素在血管内皮细胞中的多向性作用,以保护小鼠免受动脉粥样硬化的影响。Metab细胞,2012年。15(3):P。372-81。

野生型小鼠和大鼠一般对动脉粥样硬化有抵抗力,需要更极端的饮食操作来改变脂蛋白谱,形成轻度动脉粥样硬化(泡沫细胞、脂肪条纹)。现代配方完全是由纯化成分制成的,因为据报道,这种更精细的方法可以减少较少精制和较传统饮食方法引起的胆结石和肝脏损害的发生率。为了在野生型动物中诱导轻度动脉粥样硬化,可对“西方”纯化饲料进行改良,以提高胆固醇(1-1.25%),并添加胆酸钠或胆酸等胆盐。联系我们获得更多的信息,修改,或可能的控制饮食。

添加胆固醇和胆酸盐来源的纯化高脂饮食的例子*:

  • TD.0202821%乳脂(1.25%胆固醇,0.5%胆酸)
  • TD.0923715%乳脂饮食(1%胆固醇,0.5%胆酸钠)

添加胆固醇的纯化高脂饮食的例子(没有胆酸来源):

  • TD.9612121%乳脂(1.25%胆固醇)

研究用途:

主要在野生型小鼠和大鼠诱发高胆固醇血症和轻度动脉粥样硬化(泡沫细胞、脂肪条纹)。

不会助长肥胖。

主要饮食特征:

  • 高脂饮食(体重15-20%;脂肪34-45千卡)
  • 饱和脂肪酸(SFA>总脂肪酸的55%)
  • 乳脂/黄油、可可脂
  • 蔗糖(重量占30%-50%)
  • 胆固醇(1-1.25%)
  • 巧克力源(0.5%)*

参考资料:

  1. 番茄汁番茄红素对大鼠肝脏脂肪变性的影响。j Nutr Biochem,2013年。24(11):P。1870-81
  2. 高,Q,等,动脉粥样硬化饮食加剧了小鼠缺乏谷胱甘肽过氧化物酶结肠炎。炎症肠Dis,2010年。16(12):P。2043-54
  3. Lichtman,A.H.,等,高脂血症和动脉粥样硬化病变的发展,低密度脂蛋白受体缺乏的小鼠,喂食定义半纯化饮食与不含胆酸。Arteroscler Thromb VASc Biol,1999年。19(8):P。1938-44年。
  4. 慢性精神应激和致动脉粥样硬化饮食对小鼠主动脉免疫炎症环境的影响。BrainBehav Immun,2011年。25(8):P。1649-57
  5. Nishina,P.m.,等,动物和植物来源的饮食脂肪对C57BL/6J小鼠因饮食引起的脂肪条纹损害的影响。j Lipid RES,1993年。34(8):P。1413-22
  6. Nishina,P.m.,等,9种近交系小鼠动脉粥样硬化及血浆和肝脏脂质。脂质,1993年。28(7):P。599-605
  7. 月,P,等,增强CD 36空小鼠肝脏载脂蛋白A-I分泌及胆固醇和磷脂的外周流出。PLOS One,2010年。5(3):P。E 9906
  8. Nishina,下午,J.Verstuyft,B.Paigen,合成低脂和高脂肪饮食,用于研究小鼠动脉粥样硬化。j Lipid RES,1990年。31(5):P。859-69

*胆酸钠或胆酸有助胆固醇和脂肪的吸收,并可透过胆汁酸合成减少胆固醇的排出。然而,如果你的研究不想包括胆酸盐的来源,没有胆酸盐的饮食是可用的。看见TD.96121为了纯正的饮食TD.94059混合饮食。请与我们联系,了解其他选项。

贝弗利·派根和他的同事首先通过喂养一种混合性动脉粥样硬化饮食来描述C57BL/6小鼠动脉粥样硬化的发展。这种混合饲料是通过将一种天然成分的老鼠饲料按3:1的比例与浓缩的纯化饲料(含5%胆固醇和2%胆酸钠;称为Thoms-Hartroft饮食)混合而成的。产生的混合物在TD.88051/TD.90221(同配方)含有~15.8%脂肪、1.25%胆固醇和0.5%胆酸钠。这组人后来将混合动脉粥样硬化饮食方法与更现代的“西方”纯化动脉粥样硬化饮食方法进行了比较,并添加了胆固醇和胆酸盐,发现混合动脉粥样硬化饮食会导致更多的胆结石和肝脏损伤。混合饮食含有多种未精制的成分,这些成分可能会改变血脂代谢和动脉粥样硬化的发生,并且不允许对成分和营养物进行精确控制,以用于慢性病的研究。虽然已经开发出了更精细的饮食,但混合动脉粥样硬化饮食仍然是野生型小鼠和大鼠诱发轻度动脉粥样硬化和胆结石的流行食品。联系我们获得更多的信息,修改,或可能的控制饮食。

添加胆固醇和胆酸盐的混合高脂饮食实例*:

  • TD.88051和TD.90221(相同的配方)是特克拉德混合动脉粥样硬化饮食的产品代码。

添加胆固醇的混合高脂饮食的例子(没有胆酸来源):

  • TD.94059

研究用途:

主要在野生型小鼠和大鼠诱发高胆固醇血症和轻度动脉粥样硬化(泡沫细胞、脂肪条纹)。

不会助长肥胖。

也用于造石(胆石)啮齿动物的研究。

主要饮食特征:

  • 75%的啮齿动物饲养员;25%的纯化成分
  • 高脂肪(体重约15%;脂肪37%千卡)
  • 饱和脂肪酸(SFA>总脂肪酸的45%)
  • 胆固醇(1.25%)
  • 巧克力源(0.5%)*

参考资料:

  1. Nishina,下午,J.Verstuyft,B.Paigen,合成低脂和高脂肪饮食,用于研究小鼠动脉粥样硬化。j Lipid RES,1990年。31(5):P。859-69
  2. Clee,S.M.,等,血浆和血管壁脂蛋白脂肪酶在动脉粥样硬化中有不同的作用。j Lipid RES,2000年。41(4):P。521-31
  3. George,J.等人,用热休克蛋白-65免疫C57BL/6J小鼠,促进了脂肪条纹的形成。Arteroscler Thromb VASc Biol,1999年。19(3):P。505-10
  4. Miyake,J.H.,等,胆固醇-7-α-羟化酶基因表达对C57BL/6J小鼠动脉粥样硬化的预防作用。Arteroscler Thromb VASc Biol,2002年。22(1):P。121-6
  5. Paigen,B,等,小鼠动脉粥样硬化病变的定量评估。动脉粥样硬化,1987年。68(3):P。231-40。
  6. Schreyer,S.A.,D.L.Wilson和R.C.LeBoeuf,C57BL/6小鼠以高脂饮食作为糖尿病加速动脉粥样硬化的模型。动脉粥样硬化,1998年。136(1):P。17-24。
  7. Vergnes,L,等,胆固醇和胆酸组成的动脉粥样硬化饮食诱导不同阶段的肝脏炎症基因的表达。j Biol Chem,2003年。278(44):P。42774-84。

*胆酸钠或胆酸有助胆固醇和脂肪的吸收,并可透过胆汁酸合成减少胆固醇的排出。然而,如果你的研究不想包括胆酸盐的来源,没有胆酸盐的饮食是可用的。看见TD.96121为了纯正的饮食TD.94059混合饮食。请与我们联系,了解其他选项。

标准的,添加胆固醇的天然成分饮食是用来诱导高胆固醇血症的。不同水平的胆固醇,脂肪和/或胆汁酸盐可以添加到众多的标准啮齿动物饮食之一,由EnvigoTeclad。在许多应用中,建议将这些成分添加到Envigo的最小到中等植物雌激素的全球啮齿动物饮食中。我们最小的植物雌激素全球啮齿动物饮食是不含豆粕的,限制了植物雌激素对你的研究结果的影响。豆粕是一种常见的植物雌激素来源,它可以减少主动脉脂肪条纹的发育,改善血浆胆固醇,从而降低动脉粥样硬化的风险。限制饮食豆粕可能会减少饮食诱导动脉粥样硬化模型中的混杂变量。联系营养学家讨论其他饮食选择。

添加胆固醇的最小和中度植物雌激素啮齿动物饮食的例子:

  • TD.1200971%胆固醇饮食(2020年-最小植物雌激素)
  • TD.078412%胆固醇饮食(2016年-最小植物雌激素)
  • TD.013832%胆固醇(2018年-中度植物雌激素)

研究用途:

在转基因和野生型模型中诱导高胆固醇血症而不促进肥胖。

主要饮食特征:

  • 标准的、以谷物为基础的啮齿动物饮食
  • 最小/中度植物雌激素饮食建议
  • 胆固醇(1-4%)

参考资料:

  1. 贝尔奇,J,等,对小鼠体内微血管内皮功能的纵向评估。Microvasc RES,2013年。85:P.86-92
  2. 哈特维森,K,等,饮食诱导高胆固醇血症小鼠模型研究动脉粥样硬化无肥胖和代谢综合征。Arteroscler Thromb VASc Biol,2007年。27(4):P。878-85

兔子、仓鼠和猪是动脉粥样硬化的常见模型。请与营养师联系,了解有关信息和公式示例。看见兔子、猪和其他物种有关信息和公式示例。

Atherogenic

Diet can be a useful tool to induce or accelerate atherosclerosis in laboratory animal models.Key dietary features used to induce atherosclerosis in rodents vary depending on the research model, desired endpoint, and length of feeding.While formulations of atherogenic diets continue to evolve, the options that are well-described in the literature are summarized below.For more information on each diet option and literature references see the expandable tabs following the diet table.

Research use Key dietary features Examples
“Western” purified atherogenic diet
Accelerated hypercholesterolemia and plaque formation in genetically modified models such as Apoe and Ldlr deficient mice.

Used for diet induced obesity in a variety of rodent models.

  • High fat diet (20 – 23% by weight; 40 – 45% kcal from fat)
  • Saturated fatty acids (SFA >60% of total fatty acids)
  • Milkfat/butterfat
  • Sucrose (34% by weight)
  • Cholesterol (0.2% total)
TD.88137
TD.10885
“Western” purified atherogenic diet with added cholesterol and cholate source*
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.

Will not promote obesity.

  • High fat diet (15 – 20% by weight; 34 – 45% kcal from fat)
  • Saturated fatty acids (SFA >55% of total fatty acids)
  • Milkfat/butterfat, cocoa butter
  • Sucrose (30-50% by weight)
  • Cholesterol (1 – 1.25%)
  • Cholate Source (0.5%)*
TD.02028
TD.09237
Hybrid high fat diets with added cholesterol and cholate source*
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.

Will not promote obesity.

Also used for lithogenic (gallstone) rodent studies.

  • 75% rodent breeder diet; 25% purified ingredients
  • High fat (~15% by weight; 37% kcal from fat)
  • Saturated fatty acids (SFA >45% of total fatty acids)
  • Cholesterol (1.25%)
  • Cholate source (0.5%)*
TD.88051
TD.90221
Standard diets with added cholesterol
Induce hypercholesterolemia in genetically modified and wild type models without promoting obesity.
  • Standard, grain-based rodent diet
  • Minimal/moderate phytoestrogen diets recommended
  • Cholesterol (1 – 4%)
TD.120097
TD.07841
TD.01383

*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis. However, if including a cholate source is not desired for your research, diets without cholate are available.

COLLAPSE ALL TABS

“Western” style diets are fed to genetically-modified cardiovascular models, such as Apoe and Ldlr deficient mice, to accelerate and enhance hypercholesterolemia and plaque formation and to elicit phenotypes commonly associated with metabolic syndrome. Within the atherogenic literature, a “Western” diet typically is described as a purified rodent diet with 20-23% milkfat/butterfat, 0.2% total cholesterol, and 34% sucrose by weight. TD.88137 is an example of a “Western” style diet that was originally designed to characterize and enhance atherosclerosis development in a newly generated Apoe-deficient mouse model. Contact us for more information about “Western” style diets, modifications, or possible control diets.

Examples:

  • TD.88137    Adjusted calories diet (42% from fat, 0.2% total cholesterol)
  • TD.10885    45% fat Kcal diet (0.2% total cholesterol)

Research use:

Accelerated hypercholesterolemia and plaque formation in genetically-modified models, such as Apoe and Ldlr deficient mice.

Used for diet-induced obesity in a variety of rodent models.

Key dietary features:

  • High Fat Diet (20-23% by weight; 40 – 45% kcal from fat)
  • Saturated fatty acids (SFA >60% of total fatty acids)
  • Milkfat/butterfat
  • Sucrose (34% by weight)
  • Cholesterol (0.2% total)

References:

  1. Febbraio, M., et al., Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J Clin Invest, 2000. 105(8): p. 1049-56.
  2. Huszar, D., et al., Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. Arterioscler Thromb Vasc Biol, 2000. 20(4): p. 1068-73.
  3. Nakashima, Y., et al., ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb, 1994. 14(1): p. 133-40.
  4. Nakashima, Y., et al., Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler Thromb Vasc Biol, 1998. 18(5): p. 842-51.
  5. Plump, A.S., et al., Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell, 1992. 71(2): p. 343-53.
  6. Towler, D.A., et al., Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J Biol Chem, 1998. 273(46): p. 30427-34.
  7. Tsuchiya, K., et al., FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab, 2012. 15(3): p. 372-81.

Wild type mice and rats generally are resistant to atherosclerosis, requiring more extreme dietary manipulation to modify lipoprotein profiles and develop mild atherosclerosis (foam cells, fatty streaks). Modern formulations are made completely of purified ingredients because this more refined approach has been reported to decrease the incidence of gallstones and liver damage associated with less refined and more traditional dietary approaches. To induce mild atherosclerosis in wild type animals, the “Western” purified diet can be modified to increase cholesterol (1-1.25%) and add a bile salt such as sodium cholate or cholic acid. Contact us for more information, modifications, or possible control diets.

Examples of purified high fat diets with added cholesterol and cholate source*:

  • TD.02028    21% milkfat (1.25% cholesterol, 0.5% cholic acid)
  • TD.09237    15% milkfat diet (1% cholesterol, 0.5% sodium cholate)

Examples of purified high fat diets with added cholesterol (without cholate source):

  • TD.96121    21% milkfat (1.25% cholesterol)

Research Use:

Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) primarily in wild type mice and rats.

Will not promote obesity.

Key dietary features:

  • High fat diet (15-20% by weight; 34 – 45% kcal from fat)
  • Saturated fatty acids (SFA >55% of total fatty acids)
  • Milkfat/butterfat, cocoa butter
  • Sucrose (30-50% by weight)
  • Cholesterol (1 – 1.25%)
  • Cholate source (0.5%)*

References:

  1. Bernal, C., et al., Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis. J Nutr Biochem, 2013. 24(11): p. 1870-81.
  2. Gao, Q., et al., Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase. Inflamm Bowel Dis, 2010. 16(12): p. 2043-54.
  3. Lichtman, A.H., et al., Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. Arterioscler Thromb Vasc Biol, 1999. 19(8): p. 1938-44.
  4. Marcondes, M.C., et al., Effects of chronic mental stress and atherogenic diet on the immune inflammatory environment in mouse aorta. Brain Behav Immun, 2011. 25(8): p. 1649-57.
  5. Nishina, P.M., et al., Effects of dietary fats from animal and plant sources on diet-induced fatty streak lesions in C57BL/6J mice. J Lipid Res, 1993. 34(8): p. 1413-22.
  6. Nishina, P.M., et al., Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids, 1993. 28(7): p. 599-605.
  7. Yue, P., et al., Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice. PLoS One, 2010. 5(3): p. e9906.
  8. Nishina, P.M., J. Verstuyft, and B. Paigen, Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res, 1990. 31(5): p. 859-69.

*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis. However, if including a cholate source is not desired for your research, diets without cholate are available. See TD.96121for a purified diet and TD.94059 for a hybrid diet. Contact us for additional options.

Beverly Paigen and colleagues first characterized atherosclerosis development in C57BL/6 mice by feeding a hybrid atherogenic diet. The hybrid diet was created by mixing a natural ingredient mouse diet in a 3:1 ratio with a concentrated purified diet (containing 5% cholesterol and 2% sodium cholate; referred to as Thomas-Hartroft diet). The resulting mixture recreated in TD.88051/TD.90221 (same formula) contains ~15.8% fat, 1.25% cholesterol, and 0.5% sodium cholate. This group later compared the hybrid atherogenic diet approach to the more modern “western” purified atherogenic diet with added cholesterol and cholate and found that the hybrid atherogenic diet induced more gallstones and liver damage. Hybrid diets contain a variety of unrefined ingredients that may modify lipid metabolism and atherogenesis and do not allow for precise control of ingredients and nutrients for the study of chronic diseases. Although more refined diets have been developed, hybrid atherogenic diets are still popular for inducing mild atherosclerosis and gallstones in wild type mice and rats. Contact us for more information, modifications, or possible control diets.

Examples of hybrid high-fat diets with added cholesterol and cholate source*:

  • TD.88051 and TD.90221 (same formula) are Teklad product codes for hybrid atherogenic diets

Example of hybrid high-fat diet with added cholesterol (without cholate source):

  • TD.94059

Research Use:

Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) primarily in wild type mice and rats.

Will not promote obesity.

Also used for lithogenic (gallstone) rodent studies.

Key dietary features:

  • 75% rodent breeder diet; 25% purified ingredients
  • High fat (~15% by weight; 37% kcal from fat)
  • Saturated fatty acids (SFA >45% of total fatty acids)
  • Cholesterol (1.25%)
  • Cholate source (0.5%)*

References:

  1. Nishina, P.M., J. Verstuyft, and B. Paigen, Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res, 1990. 31(5): p. 859-69.
  2. Clee, S.M., et al., Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. J Lipid Res, 2000. 41(4): p. 521-31.
  3. George, J., et al., Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein-65. Arterioscler Thromb Vasc Biol, 1999. 19(3): p. 505-10.
  4. Miyake, J.H., et al., Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice. Arterioscler Thromb Vasc Biol, 2002. 22(1): p. 121-6.
  5. Paigen, B., et al., Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis, 1987. 68(3): p. 231-40.
  6. Schreyer, S.A., D.L. Wilson, and R.C. LeBoeuf, C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis. Atherosclerosis, 1998. 136(1): p. 17-24.
  7. Vergnes, L., et al., Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem, 2003. 278(44): p. 42774-84.

*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis. However, if including a cholate source is not desired for your research, diets without cholate are available. See TD.96121for a purified diet and TD.94059 for a hybrid diet. Contact us for additional options.

Standard, natural ingredient diets with cholesterol added are fed to induce hypercholesterolemia. Various levels of cholesterol, fat, and/or bile salts can be added to one of the numerous standard rodent diets stocked by Envigo Teklad. For many applications, adding these components to Envigo’s minimal-to-moderate phytoestrogen global rodent diets is recommended. Our minimal phytoestrogen global rodent diets are soybean meal free, limiting the effect of phytoestrogens on your research outcomes. Soybean meal, a common dietary source of phytoestrogens, has been shown to decrease aortic fatty streak development and modify plasma cholesterol, which may reduce the risk of developing atherosclerosis. Limiting dietary soybean meal may reduce confounding variables within your dietary-induced atherosclerosis model. Contact a nutritionist to discuss additional diet options.

Examples of minimal and moderate phytoestrogen rodent diets with added cholesterol:

  • TD.120097  1% cholesterol diet (2020 – minimal phytoestrogens)
  • TD.07841    2% cholesterol diet (2016 – minimal phytoestrogens)
  • TD.01383    2% cholesterol (2018 – Moderate phytoestrogens)

Research use:

Induce hypercholesterolemia in genetically-modified and wild type models without promoting obesity.

Key dietary features:

  • Standard, grain-based rodent diet
  • Minimal/moderate phytoestrogen diets recommended
  • Cholesterol (1 – 4%)

References:

  1. Belch, J.J., et al., Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo. Microvasc Res, 2013. 85: p. 86-92.
  2. Hartvigsen, K., et al., A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol, 2007. 27(4): p. 878-85.

Rabbits, hamsters, and swine are common models of atherosclerosis. Contact a nutritionist for information and formula examples. See rabbit, swine and other species for information and formula examples.

Harlan TD.88137 高脂饲料 Adjusted Kcal Diet (42% from fat)

Harlan TD.88137 高脂饲料 Adjusted Kcal Diet (42% from fat)
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Harlan TD.88137 高脂饲料 Adjusted Kcal Diet (42% from fat)
A staple of atherosclerosis research
More than 25 years ago, our nutritionists collaborated with researchers at Rockefeller University to develop a diet with features of a ‘Western Diet’ to characterize and enhance atherosclerosis development in their newly generated Apoe deficient mouse model. With over 200 unique users worldwide, TD.88137 continues to be fed to genetically modified cardiovascular models to accelerate and enhance hypercholesterolemia and plaque formation.
Formula                                             g/Kg
Casein                                              195.0
DL-Methionine                                     3.0
Sucrose                                            341.46
Corn Starch                                       150.0
Andydrous Milkfat                               210.0
Cholesterol                                          1.5
Cellulose                                              50.0
Mineral Mix, AIN-76 (170915)               35.0
Calcium Carbonate                               4.0
Vitamin Mix, Teklad (40060)                10.0
Ethoxyquin                                          0.04
Critical dietary features of TD.88137 related to atherosclerosis development include:
++Cholesterol (0.2% total cholesterol)
++Total fat (21% by weight; 42% kcal from fat)
++High in saturated fatty acids  (>60% of total fatty acids)
++High sucrose (34% by weight)
Typical fatty acid profile of TD.88137
Typical fatty acid analysis,% of diet1                   Mean                             SD
Total                                                                    20.7                                1.5
Saturated fat                                                       12.8                                0.8
Monounsaturated fat                                             5.6                                0.5
Polyunsaturated fat                                             1.0                                  0.2
Unknown2                                                           1.3                                   0.3
Selected nutrient information1
Key points from the literature
TD.88137 has been used to accelerate atherosclerosis development in Apoe and Ldlr deficient models:
++In Apoe deficient mice, plasma cholesterol triples to >1500 mg/dL within three weeks (1, 2). Foam cell and lesion development occurs within 6-10 weeks
(2-4). Fibrous plaque formation is observed at 15 weeks with the development of fibrous caps after 20 weeks (2).
++Ldlr deficient mice fed for two weeks increase plasma cholesterol to >800 mg/dL and triglyceride to >300 mg/dL (5). After six weeks of feeding, hyperglycemia, hyperinsulinemia and dyslipidemia develop with small foam cell lesions in the aortic
arch (6, 7).
With over 420 citations, uses of TD.88137 continue to evolve and include atherosclerosis, obesity, non-alcoholic steatohepatitis (NASH), osteoporosis,
hypertension and metabolic syndrome. Contact us for a more extensive reference list.
Control diet options for TD.88137
Natural ingredient diets
++Also referred to as standard diets or chow
++Diets differ in the source and level of nutrients as well as the presence of non-nutritive factors (such as phytates or phytoestrogens) compared
to TD.88137
++Limits inferences to differences in dietary pattern versus a specific dietary component
Ingredient matched, low fat diets
++Controls for the type of ingredients, non-nutritive components and the source and level of specific nutrients
++Suggested ingredient matched, low fat dietary controls for TD.88137 listed below; data sheets can be found on our website at envigo.com
Suggested ingredient matched, low fat controls

References  参考文献
1. Plump, A.S., et al., Severe hypercholesterolemia and atherosclerosis in
apolipoprotein E-deficient mice created by homologous recombination in
ES cells. Cell, 1992. 71(2): p. 343-53.
2. Nakashima, Y., et al., Apoe-deficient mice develop lesions of all phases of
atherosclerosis throughout the arterial tree. Arterioscler Thromb, 1994.
14(1): p. 133-40.
3. Febbraio, M., et al., Targeted disruption of the class B scavenger receptor
CD36 protects against atherosclerotic lesion development in mice.
J Clin Invest, 2000. 105(8): p. 1049-56.
4. Nakashima, Y., et al., Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone
sites on the endothelium in the Apoe-deficient mouse. Arterioscler Thromb
Vasc Biol, 1998. 18(5): p. 842-51.
5. Towler, D.A., et al., Diet-induced diabetes activates an osteogenic gene regulatory
program in the aortas of low density lipoprotein receptor-deficient mice.
J Biol Chem, 1998. 273(46): p. 30427-34.
6. Tsuchiya, K., et al., FoxOs integrate pleiotropic actions of insulin in vascular
endothelium to protect mice from atherosclerosis. Cell Metab, 2012. 15(3): p. 372-81.
7. Huszar, D., et al., Increased LDL cholesterol and atherosclerosis in LDL receptordeficient
mice with attenuated expression of scavenger receptor B1. Arterioscler
Thromb Vasc Biol, 2000. 20(4): p. 1068-73.
8. Yang, B., et al., Changes of skeletal muscle adiponectin content in diet-induced
insulin resistant rats. Biochem Biophys Res Commun, 2006. 341(1): p. 209-17.
9. Schafer, K., et al., Leptin promotes vascular remodeling and neointimal growth
in mice. Arterioscler Thromb Vasc Biol, 2004. 24(1): p. 112-7.
10. Lijnen, H.R., et al., Nutritionally induced obesity is attenuated in transgenic mice
overexpressing plasminogen activator inhibitor-1. Arterioscler Thromb Vasc
Biol, 2003. 23(1): p. 78-84.
11. Maquoi, E., et al., Modulation of adipose tissue expression of murine matrix
metalloproteinases and their tissue inhibitors with obesity. Diabetes, 2002.
51(4): p. 1093-101.
12. VanSaun MN, et al. 2009. High fat diet induced hepatic steatosis establishes a
permissive microenvironment for colorectal metastases and promotes primary
dysplasia in a murine model. Am J Pathol 175:355-64.
13. Dixon LJ, et al. 2013. Caspase-1 as a central regulator of high fat diet-induced
non-alcoholic steatohepatitis. PLoS One 8:e56100.

Harlan氨基酸调节饲料 Amino acid defined

Harlan氨基酸调节饲料 Amino acid defined
品牌:Harlan
货号:TD.90262
英文名称:Amino acid defined
Harlan氨基酸调节饲料 Amino acid defined
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Amino acid defined | Harlan
A few amino acid defined formulas are shown below. This type of diet is used when a diet needs to be deficient in one or more amino acids, or adjustments need to be made to specific amino acid levels.
Formula examples:
TD.99366      Amino acid diet
TD.90262      Methionine and choline deficient diet
TD.00434      Folic acid deficient diet
TD.99386      No lysine AA diet
Sometimes this type of diet is used to further reduce the background level of certain vitamins that are found in protein sources such as casein or vitamin-free (alcohol extracted) casein. Some folic acid deficient diets utilize this approach.
The amino acid profile for most amino acid defined diets is based on work by Harper and Rogers (J. Nutr. (1965) 87:267-276) and is not representative of the amino acid profile of an intact protein source such as casein. Other amino acid profiles can be specified. When an amino acid(s) is removed or reduced, isonitrogenous adjustment can be made if required.
公式实例:
TD.99366氨基酸饮食
TD.90262蛋氨酸和胆碱缺乏饮食
TD.00434叶酸缺乏饮食
TD.99386不含赖氨酸AA饮食
有时,这种饮食被用来进一步降低某些维生素的背景水平,这些维生素存在于蛋白质来源,如酪蛋白或无维生素的酪蛋白(醇提取的)酪蛋白中。一些叶酸缺乏的饮食使用这种方法。
大多数氨基酸定义的饮食的氨基酸谱是基于哈珀和罗杰斯的工作(J.Nutr)。(1965)87:267-276),不代表酪蛋白等完整蛋白质来源的氨基酸谱。还可以指定其他氨基酸谱。当氨基酸被去除或减少时,如果需要,可以进行等氮调节。
上海金畔生物科技有限公司(www.jinpanbio.com)提供生命科学研究领域系列产品,包括生化试剂、诊断试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料;修饰性PEG(Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG);Sigma、Amresco、TCI、MP bio生化试剂;WAKO日本和光纯药、日本关东化学Kanto试剂、日本三菱、日本柴田科学SIBATA;Megazyme食品分析检测试剂盒、日本共立理化学;Research diets、Harlan饲料、Bio-Serv、日本CLEA Japan品牌的动物饲料;Oxoid、Nissui日水、日本荣研、BD difco、Himedia品牌微生物培养基;免疫诊断试剂包括:Bethyl抗体;Biolegend流式抗体、Abcam、CST、Santa Cruz抗体;Roche、TOYOBO、NEB品牌的酶;中检所、TRC、药典USP、EP、Reagecon标准品;耗材和仪器包括Whatman、日本Advantec滤膜、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Wheaton瓶子、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
上海金畔生物科技有限公司
服务热线:18301939375   QQ:3258089810    3259632176
Email:  info@jinpanbio.com
官网:http://www.jinpanbio.com

Harlan TD.96208氯化钠调节饲料 NaCl dite

Harlan TD.96208氯化钠调节饲料 NaCl dite
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
NaCl adjusted (natural ingredient) | Harlan
The sodium content of natural ingredients such as corn, wheat, and soybean meal is low. Thus, these ingredients can be used to create a base diet that is sodium deficient. To this base diet, various amounts of sodium chloride salt (NaCl) can be added, and other ingredients adjusted slightly to maintain a relatively constant nutrient profile (with the exception of sodium and chloride). Below are examples from a popular series of adjusted NaCl diets. Contact us for more information.

Formula examples
Added NaCl (%) Approx. Na (%) no dye red* dye orange* dye blue* dye
Na deficient 0.01-0.02 TD.90228 TD.08290    
Possible control diets: 0.05% Na (0.1% NaCl) meets est. minimum Na requirement. Typical rodent diets contain 0.2%-0.4% Na (~0.5-1% NaCl).
0.1 0.05 TD.94268   TD.07334  
0.49 0.2 TD.96208   TD.110765  
1 0.4 TD.90229      
Diets for studies that look at effects of excess sodium consumption in rodents.
2 0.8 TD.95078   TD.130345  
4 1.6 TD.92034 TD.110078   TD.03095
8 3.2 TD.92012 TD.03142    

* When added to natural ingredient diets, these water soluble food dyes offer a slight color tint. More intense color can be achieved at higher inclusion rates.
Ask a nutritionist about additional salt concentrations or color options.
These diets are grain-based, with no animal derived ingredients, and have a background sodium content of approx. 0.01-0.02% and a background chloride content of approx. 0.06-0.07%. The selected nutrient content of the diets are as follows: approximately 19% protein, 5% fat, 3% crude fiber, 0.86% Ca, 0.64% P, 0.72% K, and 0.15% Mg.
NaCl adjusted diets are often fed to dahl salt-sensitive/resistant (rapp) inbred rats. These rats are maintained on Teklad traditional diet 7034 (0.12% NaCl) within maximum security production facilities.

盐调节(天然成分)

玉米、小麦、豆粕等天然成分的钠含量较低。因此,这些成分可以用来制造一种缺乏钠的基础饮食。在这一基础日粮中,可以添加各种量的氯化钠盐(NaCl),其他成分也可以稍加调整,以保持相对稳定的营养状况(除钠和氯化物外)。下面是一系列受欢迎的调整NaCl饮食的例子。欲了解更多信息,请与我们联系。

公式实例
添加NaCl(%) 大约。NA(%) 无染料 红*染料 橙*染料 蓝*染料
NA缺乏 0.01-0.02 TD.90228 TD.08290    
可能的对照日粮:0.05%Na(0.1%NaCl)符合EST。最低钠需要量典型的啮齿动物日粮中含0.2%~0.4%Na(~0.5%-1%NaCl).
0.1 0.05 TD.94268   TD.07334  
0.49 0.2 TD.96208   TD.110765  
1 0.4 TD.90229      
用于研究啮齿类动物摄入过量钠的影响的饮食。
2 0.8 TD.95078   TD.130345  
4 1.6 TD.92034 TD.110078   TD.03095
8 3.2 TD.92012 TD.03142    

*将这些水溶性食物染料加入天然成分的饮食中,可提供轻微的色泽。在较高的包合率下可以获得更强烈的颜色。
向营养师询问额外的盐浓度或颜色选择。
这些饮食是以谷物为基础的,没有动物来源的成分,并且背景钠含量约为。0.01-0.02%,背景氯含量约为0.01-0.02%.0.06-0.07%。日粮的营养成分为:蛋白质约19%,脂肪5%,粗纤维3%,钙0.86%,磷0.64%,钾0.72%,镁0.15%。
食盐调节后的饲料通常喂给Dahl盐敏感/耐盐(Rapp)近交系大鼠.这些老鼠传统饮食7034(0.12%NaCl)在最大安全生产设施内。
上海金畔生物科技有限公司(www.jinpanbio.com)提供生命科学研究领域系列产品,包括生化试剂、诊断试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料;修饰性PEG(Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG);Sigma、Amresco、TCI、MP bio生化试剂;WAKO日本和光纯药、日本关东化学Kanto试剂、日本三菱、日本柴田科学SIBATA;Megazyme食品分析检测试剂盒、日本共立理化学;Research diets、Harlan饲料、Bio-Serv、日本CLEA Japan品牌的动物饲料;Oxoid、Nissui日水、日本荣研、BD difco、Himedia品牌微生物培养基;免疫诊断试剂包括:Bethyl抗体;Biolegend流式抗体、Abcam、CST、Santa Cruz抗体;Roche、TOYOBO、NEB品牌的酶;中检所、TRC、药典USP、EP、Reagecon标准品;耗材和仪器包括Whatman、日本Advantec滤膜、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Wheaton瓶子、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
上海金畔生物科技有限公司
服务热线:18301939375   QQ:3258089810    3259632176
Email:  info@jinpanbio.com
官网:http://www.jinpanbio.com

Harlan Teklad动物饲料 Harlan代理

Harlan Teklad动物饲料 Harlan代理
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
harlan是美国最大大的实验动物饲料生产商,产品销售遍布全世界
Harlan is a leading provider of essential, pre-clinical and non-clinical contract research, research models, lab animal diets, and services. Our focus is on providing customers with products and services to optimize the discovery and safety of new medicines and compounds.

CA.170481 AIN-76A Purified Diet AIN-76A 纯化饲料 50kg 询价 harlan
TD.94045 AIN-93G Purified Diet AIN-93G 纯化饲料 50kg 询价 harlan
TD.94048 AIN-93M Purified Diet AIN-93M 纯化饲料 50kg 询价 harlan
TD.94096 version of AIN-76A suitable for irradiation (vitamin levels are increased) 适合辐照的AIN-76A 饲料 维生素含量增加 50kg 询价 harlan
TD.97184 version of AIN-93G suitable for irradiation (vitamin levels are increased) 适合辐照的AIN-93G 饲料 维生素含量增加 50kg 询价 harlan
TD.00102 version of AIN-93M suitable for irradiation (vitamin levels are increased) 适合辐照的AIN-93M 饲料 维生素含量增加 50kg 询价 harlan
TD.95092 modification of AIN-93G where soybean oil is replaced with corn oil. AIN-93G饲料 豆油改为玉米油 50kg 询价 harlan
TD.06414 Adjusted Calories Diet (60/Fat) 卡路里调控饲料 60%脂肪 50kg 询价 harlan
TD.06415 Adjusted Calories Diet (45/Fat) 卡路里调控饲料 45%脂肪 50kg 询价 harlan
TD.03584 35% Lard Diet (Adj., No C) 35%猪油饲料 50kg 询价 harlan
TD.93075 Adjusted Calories Diet (55/fat) 卡路里调控饲料 55%脂肪 50kg 询价 harlan
TD.95217 Adjusted Fat Diet 脂肪控饲料 50kg 询价 harlan
TD.96132 Adjusted Fat Diet 脂肪控饲料 50kg 询价 harlan
TD.88137 Adjusted Kcal Diet (42% from fat 大卡调控饲料 42%脂肪 50kg 询价 harlan
TD.08811 45% Kcal Fat Diet (21% MF, 2% SBO) 45%大卡脂肪饲料 42%脂肪 50kg 询价 harlan
TD.06416 Adjusted Calories Diet (10/Fat) (a possible control for TD.06415 & TD.06414 listed above) 卡路里调控饲料 10%脂肪 50kg 询价 harlan
TD.08810 Low Glycemic Control Diet 低血糖饲料 50kg 询价 harlan
TD.96355 Ketogenic Diet 生酮饲料 50kg 询价 harlan
TD.84224 Essential Fatty Acid Deficient Diet 必须氨基酸缺损饲料 50kg 询价 harlan
TD.88137 Adjusted Calories Diet (42% from fat) 卡路里调控饲料 42%脂肪 50kg 询价 harlan
TD.88051 Cocoa Butter and Purina Chow Diet 椰子油和Purina Chow饲料 50kg 询价 harlan
TD.90221 Cocoa Butter Diet with 75% Purina Mouse (5015) 50kg 询价 harlan
TD.94059 5015, Cocoa Butter, Chol., etc. (excludes cholate) 50kg 询价 harlan
TD.02028 Atherogenic Rodent Diet (1.25% Chol. & 0.5% Cholic Acid) 50kg 询价 harlan
TD.01383 2018 + 2% Cholesterol 50kg 询价 harlan
TD.86143 Vitamin A Deficient Diet 50kg 询价 harlan
TD.89123 Vitamin D Deficient Diet 50kg 询价 harlan
TD.88163 Vitamin E Deficient Diet 50kg 询价 harlan
TD.95247 Folic Acid Deficient Diet 50kg 询价 harlan
TD.80396 Iron Deficient Diet 50kg 询价 harlan
TD.85419 Zinc Deficient Diet 50kg 询价 harlan
TD.88239 Potassium Deficient Diet 50kg 询价 harlan
TD.95027 Low Calcium Diet (0.4% P) 50kg 询价 harlan
TD.96348 Diet (20% Lactose, 2% Ca, 1.25% P) 50kg 询价 harlan
TD.92163 Selenium Deficient Diet 50kg 询价 harlan
TD.95125 Iodine Deficient (0.15% PTU) 50kg 询价 harlan
TD.93328 Protein Free Diet 50kg 询价 harlan
TD.90016 6% Protein Diet 50kg 询价 harlan
TD.91352 20% Protein Diet 50kg 询价 harlan
TD.90018 40% Protein Diet 50kg 询价 harlan
TD.89247 60% Fructose Diet 50kg 询价 harlan
TD.86489 Diet with Adjusted Sucrose/Cornstarch 50kg 询价 harlan
TD.96348 Diet (20% Lactose, 2% Ca, 1.25% P) 50kg 询价 harlan
TD.98090 70% Carbohydrate Diet 50kg 询价 harlan
TD.96355 Ketogenic Diet (almost no carbohydrate) 50kg 询价 harlan
TD.99366 Amino Acid Diet 50kg 询价 harlan
TD.90262 Methionine & Choline Deficient Diet 50kg 询价 harlan
TD.00434 Folic Acid Deficient Diet 50kg 询价 harlan
TD.99386 No Lysine AA Diet 50kg 询价 harlan
TD.90228 Sodium Deficient Diet 50kg 询价 harlan
TD.96208 0.49% NaCl Diet 50kg 询价 harlan
TD.90229 1% NaCl Diet 50kg 询价 harlan
TD.92034 4% NaCl Diet 50kg 询价 harlan
TD.92012 8% NaCl Diet 50kg 询价 harlan
TD.01306 Rodent Diet (2018 + 625 doxycycline) 50kg 询价 harlan
TD.98186 Rodent Diet (7012 + 200 doxycycline) 50kg 询价 harlan
TD.92033 Swine Diet (15% Lard, 1.2% Cholesterol) 50kg 询价 harlan
TD.92052 Swine Diet (15% Lard, 1.5% Cholesterol) 50kg 询价 harlan
TD.93296 Swine Diet (15% Lard, 2% Cholesterol) 50kg 询价 harlan
CA.40060 Teklad Vitamin Mix 50kg 询价 harlan
CA.40077 AIN-76A Vitamin Mix 50kg 询价 harlan
TD.94047 AIN-93 Vitamin Mix 50kg 询价 harlan
CA.170915 AIN-76 Mineral Mix 50kg 询价 harlan
TD.94046 AIN-93G Mineral Mix 50kg 询价 harlan
TD.94049 AIN-93M Mineral Mix 50kg 询价 harlan
TD.79055 Calcium & Phosphorus Deficient Mineral Mixed based on AIN-76 50kg 询价 harlan
TD.98057 Calcium & Phosphorus Deficient Mineral Mixed based on AIN-93 50kg 询价 harlan

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