ad-MED Vitrigel ™ 2

ad-MED Vitrigel™ 2 is a cell culture insert using a collagen Vitrigel™ membrane as a scaffold for cell culturing. ad-MED Vitrigel™ 2 indicates high adhesive property against various kind of animal cells. Also, it is useful for fabrication of three- dimensional tissue models appropriate for drugs and cosmetics development. Recently, it’s considered as a material for MPS devices as well, and it’s a product with high potential.

Vitrigel™ is a registered trademark of National Agriculture and Food Research Organization (NARO).
This product is supported by Agri-Health Translational Research Project from the Ministry of Agriculture,Foresty and Fisheries of Japan.

Collagen Vitrigel™

When the moisture of the collagen gel is removed, the collagen fiber density increases and the collagen gel turns into a film. Because this dehydration process is called “Vitrification”, the film produced by this method is called “Vitrigel™ ”.

Features

Excellent visibility for observation
These images indicate transparency of each membranes. Each cell culture inserts were placed on the black cloth after rehydration with PBS. Transparency of collagen Vitrigel™ membrane is higher than that of PET or PTFE membrane. Collagen Vitrigel™ membrane is low fluorescent membrane. It makes high-contrast fluorescent observation.

High adhesive property / Promotion of cell spreading
ad-MED Vitrigel™ 2 indicate excellent cell adhesive property and proliferation acitivity as compare to other cell culture inserts using plastic membrane.

Permeability
FITC-dextran (MW:4,000 or 10,000 or 40,000) was used as a permeable substance.These results suggested that the permeability of collagen vitrigel membrane was higher than that of PET (0.4 μm) membrane and dependent on the molecular weight of a substance unlike the PET membrane.

Long-term culture
The Vitrigel™ culture method can maintain CYP metabolic activities for at least 3 weeks.

*this data is cited by ChemTime 266 B

Designs for easier handling

Appropriate for constructing co-culture systems
ad-MED Vitrigel™ 2 allow to co-culture different type of cells on both inner and outer side of collagen Vitrigel™ membrane by using option ring.

Collagen Vitrigel™ 2 membrane
We also supply Vitrigel™ in processable membrane form in 12 well or 24 well size.
Custom-made products are also available, please contact us.

Product lineup

brochure

ad-MED Vitrigel™ 2 series

References

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