Anti-RPH3A Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-RPH3A Polyclonal Antibody

品牌:solarbio | 货号:K004741P

英文名称 Anti-RPH3A Polyclonal Antibody
宿主 Rabbit
别名 RPH3A
应用 WB
稀释比例 WB 1:500-2000.
交叉反应 Mouse Rat
蛋白分子量 77kDa
Gene ID 22895
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human RPH3A
性状 液体
Public Immunogen Range Recombinant protein of human RPH3A
Subcellular Locations Cell junction Membrane Peripheral membrane protein synapse
Swiss Prot Q9Y2J0
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is thought to be an effector for RAB3A, which is a small G protein that acts in the late stages of neurotransmitter exocytosis. The encoded protein may be involved in neurotransmitter release and synaptic vesicle traffic.

Anti-EGLN3 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-EGLN3 Polyclonal Antibody

品牌:solarbio | 货号:K008225P

英文名称 Anti-EGLN3 Polyclonal Antibody
宿主 Rabbit
别名 PHD3;HIFPH3;HIFP4H3
应用 WB
稀释比例 WB 1:200-1000.
交叉反应 Human Mouse Rat
蛋白分子量 27kDa
Gene ID 112399
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human EGLN3
性状 液体
Public Immunogen Range Recombinant protein of human EGLN3
Swiss Prot Q9H6Z9
克隆类型 Polyclonal Antibody
背景资料 Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis.