Anti-DHFR Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-DHFR Polyclonal Antibody

品牌:solarbio | 货号:K007462P

英文名称 Anti-DHFR Polyclonal Antibody
宿主 Rabbit
别名 DYR;DHFRP1
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-300.
交叉反应 Human Mouse Rat
蛋白分子量 21kDa
Gene ID 1719
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human DHFR
性状 液体
Public Immunogen Range Recombinant protein of human DHFR
Subcellular Locations Cytoplasm
Swiss Prot P00374
克隆类型 Polyclonal Antibody
背景资料 Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene.

Anti-SPATA13 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-SPATA13 Polyclonal Antibody

品牌:solarbio | 货号:K006838P

英文名称 Anti-SPATA13 Polyclonal Antibody
宿主 Rabbit
别名 ASEF2;ARHGEF29;RP11-307N16.3
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:25-100.
交叉反应 Human Mouse
蛋白分子量 75kDa
Gene ID 221178
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human SPATA13
性状 液体
Public Immunogen Range Recombinant protein of human SPATA13
Subcellular Locations Cytoplasm
Swiss Prot Q96N96
克隆类型 Polyclonal Antibody
背景资料 Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.

Anti-CCNA2 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CCNA2 Polyclonal Antibody

品牌:solarbio | 货号:K003520P

英文名称 Anti-CCNA2 Polyclonal Antibody
宿主 Rabbit
别名 CCN1;CCNA
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 49kDa
Gene ID 890
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human CCNA2
性状 液体
Public Immunogen Range Recombinant protein of human CCNA2
Subcellular Locations Cytoplasm Nucleus
Swiss Prot P20248
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M.