Anti-STAT6 Polyclonal Antibody
品牌：solarbio | 货号：K006647P
| 英文名称 | Anti-STAT6 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | STAT6B;STAT6C;D12S1644;IL-4-STAT |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 94kDa |
| Gene ID | 6778 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human STAT6 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human STAT6 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P42226 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. |