Anti-STAT6 Polyclonal Antibody
品牌:solarbio | 货号:K006647P
英文名称 |
Anti-STAT6 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
STAT6B;STAT6C;D12S1644;IL-4-STAT |
应用 |
WB |
稀释比例 |
WB 1:500-2000. |
交叉反应 |
Human Mouse |
蛋白分子量 |
94kDa |
Gene ID |
6778 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human STAT6 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human STAT6 |
Subcellular Locations |
Cytoplasm Nucleus |
Swiss Prot |
P42226 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. |