日度归档：2023年12月12日

Anti-COL1A2 Polyclonal Antibody-一抗-抗体-蛋白与免疫

发表于由

Anti-COL1A2 Polyclonal Antibody

品牌：solarbio | 货号：K004211P

英文名称 Anti-COL1A2 Polyclonal Antibody
宿主 Rabbit
别名 OI4
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Mouse Rat
蛋白分子量 129kDa
Gene ID 1278
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human COL1A2
性状 液体
Public Immunogen Range A synthetic peptide of human COL1A2
Subcellular Locations Secreted extracellular matrix extracellular space
Swiss Prot P08123
克隆类型 Polyclonal Antibody
背景资料 This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.