Anti-MLKL Polyclonal Antibody
品牌:solarbio | 货号:K004074P
英文名称 |
Anti-MLKL Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
9130019I15Rik |
应用 |
WB IHC IF |
稀释比例 |
WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
交叉反应 |
Human Rat |
蛋白分子量 |
54kDa |
Gene ID |
74568 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of mouse MLKL |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of mouse MLKL |
Subcellular Locations |
Plasma membrane |
Swiss Prot |
Q9D2Y4 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. |