Anti-MLKL Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-MLKL Polyclonal Antibody

品牌:solarbio | 货号:K004074P

英文名称 Anti-MLKL Polyclonal Antibody
宿主 Rabbit
别名 9130019I15Rik
应用 WB IHC IF
稀释比例 WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
交叉反应 Human Rat
蛋白分子量 54kDa
Gene ID 74568
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of mouse MLKL
性状 液体
Public Immunogen Range Recombinant protein of mouse MLKL
Subcellular Locations Plasma membrane
Swiss Prot Q9D2Y4
克隆类型 Polyclonal Antibody
背景资料 This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene.