Anti-CDK4 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CDK4 Polyclonal Antibody

品牌:solarbio | 货号:K106719P

英文名称 Anti-CDK4 Polyclonal Antibody
宿主 Rabbit
别名 CDK4;Cell division protein kinase 4;CMM3;cyclin dependent kinase 4;PSK J3
应用 IHC
稀释比例 IHC 1:50-200.
交叉反应 Human
蛋白分子量 34kDa
Gene ID 1019
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human CDK4
性状 液体
Public Immunogen Range Recombinant protein of human CDK4
Subcellular Locations Cytoplasm Nucleus
Swiss Prot P11802
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers.