日度归档：2023年7月28日

Anti-HIF2alpha Polyclonal Antibody-一抗-抗体-蛋白与免疫

发表于由

Anti-HIF2alpha Polyclonal Antibody

品牌：solarbio | 货号：K106456P

英文名称 Anti-HIF2alpha Polyclonal Antibody
宿主 Rabbit
别名 EPAS-1;HLF;Mhlf;HRF;Epas1
应用 WB
稀释比例 WB 1:3000.
交叉反应 Human Mouse Rat
蛋白分子量 65kDa
Gene ID 13819
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human HIF2alpha
性状 液体
Public Immunogen Range A synthetic peptide of human HIF2alpha
Subcellular Locations Nucleus
Swiss Prot P97481
克隆类型 Polyclonal Antibody
背景资料 Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5′-[AG]CGTG-3′ within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD