Anti-HIF2alpha Polyclonal Antibody
品牌：solarbio | 货号：K106456P
| 英文名称 | Anti-HIF2alpha Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | EPAS-1;HLF;Mhlf;HRF;Epas1 |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 65kDa |
| Gene ID | 13819 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human HIF2alpha |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human HIF2alpha |
| Subcellular Locations | Nucleus |
| Swiss Prot | P97481 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5′-[AG]CGTG-3′ within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD |