Type IV Collagen is the primary collagen found in the extracellular basement membranes separating a variety of epithelial and endothelial cells.  It is a major component of the dermal-epidermal junction where it is mostly found in the lamina densa.  It is a heterotrimeric molecule containing two α1-like and one α 2-like chains.

This Type IV Collagen is isolated from human placenta and is purified using a multi-step process.  The product is supplied as a non-sterile powder containing  5 mg of Type IV collagen per vial.  A Certificate of Analysis is available with the purchase of each product.

Type IV Collagen is typically used as a thin coating on tissue culture surfaces.  Specific instructions are found in the Directions for Use. This product is generally used in vitro as a substrate scaffold to enhance cell attachment, adherence and proliferation. Type IV collagen may be used to culture epithelial, endothelial, muscle, nerve and many other cell types. Additionally, this product is suitable for use as a substrate for collagenase assays and positive controls.

AlignCol® Matrix is a revolutionary nanostructure product with a 3D oriented collagen fibril matrix which mimics the matrices found in the body. The collagen fibrils are oriented, aligned and organized into nano-scale structures.

Using Fibralign nanoweave collagen-based materials, the purified collagen is deposited onto borosilicate glass chips at a thickness of ~ 1-3 micrometer while aligning the collagen fibrils in an exact orientation.

This product provides aligned-crimped collagen fibrils, which are aligned in the same direction on a lateral plain with additional modulation in orthogonal plane resulting in ‘ridges’ oriented perpendicular to fibril direction. This configuration replicates the organized collagen fibril bundles found in heart, ligament and tendon tissues.

AlignCol® Matrix, aligned-crimped collagen is provided on glass slides that  measure 8 X 15 mm.  An indicator is placed on the glass slide indicating the side on which the aligned collagen matrix is provided. Directions for use provide instruction on the handling of the product.