Anti-BCCIP Polyclonal Antibody
品牌:solarbio | 货号:K005929P
英文名称 |
Anti-BCCIP Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
TOK-1;TOK1 |
应用 |
WB IHC |
稀释比例 |
WB 1:500-2000. IHC 1:100-200. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
36kDa |
Gene ID |
56647 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human BCCIP |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human BCCIP |
Subcellular Locations |
Nucleus |
Swiss Prot |
Q9P287 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. |