Anti-NR1H4 Polyclonal Antibody
品牌：solarbio | 货号：K107059P
| 英文名称 | Anti-NR1H4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | Bile acid receptor;BAR;FXR;HRR1;RIP14 |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 蛋白分子量 | 56/49kDa |
| Gene ID | 9971 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human NR1H4 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human NR1H4 |
| Subcellular Locations | Nucleus? |
| Swiss Prot | Q96RI1 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid, deoxycholic acid and allocholic acid. Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5′-AGGTCA-3′ in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. |