Anti-VEGFR3 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-VEGFR3 Polyclonal Antibody

品牌:solarbio | 货号:K106902P

英文名称 Anti-VEGFR3 Polyclonal Antibody
宿主 Rabbit
别名 FLT-4;VEGFR-3;Fms-like tyrosine kinase 4;
应用 WB
稀释比例 WB 1:5000-8000.
交叉反应 Human
蛋白分子量 153/146/93kDa
Gene ID 2324
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human VEGFR3
性状 液体
Public Immunogen Range A synthetic peptide of human VEGFR3
Subcellular Locations Cytoplasm Vessel
Swiss Prot P35916
克隆类型 Polyclonal Antibody
背景资料 Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis.