Anti-VEGFR3 Polyclonal Antibody
品牌:solarbio | 货号:K106902P
英文名称 |
Anti-VEGFR3 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
FLT-4;VEGFR-3;Fms-like tyrosine kinase 4; |
应用 |
WB |
稀释比例 |
WB 1:5000-8000. |
交叉反应 |
Human |
蛋白分子量 |
153/146/93kDa |
Gene ID |
2324 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human VEGFR3 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human VEGFR3 |
Subcellular Locations |
Cytoplasm Vessel |
Swiss Prot |
P35916 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. |