Anti-ARNT2 Polyclonal Antibody
| 英文名称 | Anti-ARNT2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | WEDAS;bHLHe1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 79kDa |
| Gene ID | 9915 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ARNT2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ARNT2 |
| Subcellular Locations | Nucleus |
| Swiss Prot | Q9HBZ2 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. |