Anti-GFRA2 Polyclonal Antibody
英文名称 |
Anti-GFRA2 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
GDNFRB;NRTNR-ALPHA;NTNRA;RETL2;TRNR2 |
应用 |
WB |
稀释比例 |
WB 1:200-2000. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
52kDa |
Gene ID |
2675 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human GFRA2 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human GFRA2 |
Subcellular Locations |
Cell membrane GPI-anchor Lipid-anchor |
Swiss Prot |
O00451 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. |