Anti-PARP Monoclonal Antibody-一抗-抗体-蛋白与免疫

Anti-PARP Monoclonal Antibody

品牌:solarbio | 货号:K200026M

英文名称 Anti-PARP Monoclonal Antibody
宿主 Mouse
别名 PARP-1; Poly(ADP ribose) polymerase 1; sPARP1;ADPRT1; ADP ribosyltransferase NAD(+)
应用 WB IHC
稀释比例 WB 1:1000-3000. IHC 1:200-500.
交叉反应 Human
蛋白分子量 116kDa
Gene ID 142
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG1
免疫原 A synthetic peptide coupled to KLH
性状 液体
Public Immunogen Range A synthetic peptide coupled to KLH
Subcellular Locations Nucleus
Swiss Prot P09874
克隆号 M3
克隆类型 Monoclonal Antibody
背景资料 Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.