Anti-MCM10 Polyclonal Antibody
品牌：solarbio | 货号：K106986P
| 英文名称 | Anti-MCM10 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CNA43;DNA43;HsMCM10;MCM10;PRO2249;Protein MCM10 homolog |
| 应用 | WB IHC |
| 稀释比例 | WB 1:10000-15000. IHC 1:25-100. |
| 交叉反应 | Human |
| 蛋白分子量 | 98kDa |
| Gene ID | 55388 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human MCM10 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human MCM10 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q7L590 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified |