Anti-HLA-A Polyclonal Antibody
品牌：solarbio | 货号：K007358P
| 英文名称 | Anti-HLA-A Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | HLAA |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:20-100. |
| 交叉反应 | Human |
| 蛋白分子量 | 41kDa |
| Gene ID | 3105 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human HLA-A |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human HLA-A |
| Subcellular Locations | Cell membrane |
| Swiss Prot | P01891 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. |