Anti-KDM3B Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-KDM3B Polyclonal Antibody

品牌:solarbio | 货号:K007080P

英文名称 Anti-KDM3B Polyclonal Antibody
宿主 Rabbit
别名 5qNCA;NET22;C5orf7;JMJD1B
应用 WB IHC
稀释比例 WB 1:1000-5000. IHC 1:50-200.
交叉反应 Human Mouse
蛋白分子量 192kDa
Gene ID 51780
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human KDM3B
性状 液体
Public Immunogen Range Recombinant protein of human KDM3B
Subcellular Locations Nucleus
Swiss Prot Q7LBC6
克隆类型 Polyclonal Antibody
背景资料 JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.