Anti-NEDD4L Polyclonal Antibody
品牌：solarbio | 货号：K005649P
| 英文名称 | Anti-NEDD4L Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | NEDD4-2;NEDD4.2;PVNH7;RSP5;hNEDD4-2 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 112kDa |
| Gene ID | 23327 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human NEDD4L |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human NEDD4L |
| Subcellular Locations | Endosome Golgi apparatus |
| Swiss Prot | Q96PU5 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |