Anti-MYC Polyclonal Antibody
品牌:solarbio | 货号:K106458P
英文名称 |
Anti-MYC Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
BHLHE39;c-Myc;MRTL;MYCC |
应用 |
WB IHC |
稀释比例 |
WB 1:2000-5000.IHC 1:50-200. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
63kDa |
Gene ID |
4609 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human MYC |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human MYC |
Subcellular Locations |
Nucleus |
Swiss Prot |
P01106 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt’s lymphomas, suggesting its importance in the normal function of this gene. |