Anti-PLAT Polyclonal Antibody
品牌：solarbio | 货号：K004111P
| 英文名称 | Anti-PLAT Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | T-PA;TPA |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 63kDa |
| Gene ID | 5327 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PLAT |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PLAT |
| Subcellular Locations | Secreted extracellular space |
| Swiss Prot | P00750 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |