Anti-WISP2 Polyclonal Antibody
品牌：solarbio | 货号：K007978P
| 英文名称 | Anti-WISP2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CCN5;CT58;CTGF-L |
| 应用 | IHC |
| 稀释比例 | IHC 1:30-150. |
| 交叉反应 | Human |
| 蛋白分子量 | 27/23kDa |
| Gene ID | 8839 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human WISP2 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human WISP2 |
| Subcellular Locations | Secreted |
| Swiss Prot | O76076 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.? |