Anti-FLT3 Polyclonal Antibody
品牌：solarbio | 货号：K006909P
| 英文名称 | Anti-FLT3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | FLK2;STK1;CD135;FLK-2 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 113kDa |
| Gene ID | 2322 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human FLT3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human FLT3 |
| Subcellular Locations | Cell membrane |
| Swiss Prot | P36888 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |