Anti-RPSA Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-RPSA Polyclonal Antibody

品牌:solarbio | 货号:K005986P

英文名称 Anti-RPSA Polyclonal Antibody
宿主 Rabbit
别名 37LRP;67LR;ICAS;LAMBR;LAMR1;LBP;LBP/p40;LRP;LRP/LR;NEM/1CHD4;SA;lamR;p40
应用 WB
稀释比例 WB 1:500-2000.
交叉反应 Mouse
蛋白分子量 33kDa
Gene ID 3921
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human RPSA
性状 液体
Public Immunogen Range Recombinant protein of human RPSA
Subcellular Locations Cell membrane Cytoplasm Nucleus
Swiss Prot P08865
克隆类型 Polyclonal Antibody
背景资料 Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.