Anti-SMAD2 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-SMAD2 Polyclonal Antibody

品牌:solarbio | 货号:K005398P

英文名称 Anti-SMAD2 Polyclonal Antibody
宿主 Rabbit
别名 JV18;JV18-1;MADH2;MADR2;hMAD-2;hSMAD2
应用 WB IHC IF
稀释比例 WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 52kDa
Gene ID 4087
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human SMAD2
性状 液体
Public Immunogen Range A synthetic peptide of human SMAD2
Subcellular Locations Cytoplasm Nucleus
Swiss Prot Q15796
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic’ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.