Anti-HRG Polyclonal Antibody
| 英文名称 | Anti-HRG Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | HPRG;HRGP;THPH11 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-100. |
| 交叉反应 | Mouse Rat |
| 蛋白分子量 | 60kDa |
| Gene ID | 3273 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human HRG |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human HRG |
| Subcellular Locations | Secreted |
| Swiss Prot | P04196 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein’s effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. |