Anti-TEK Polyclonal Antibody
| 英文名称 | Anti-TEK Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | TIE2;VMCM;TIE-2;VMCM1;CD202B |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 126/109kDa |
| Gene ID | 7010 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human TEK |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human TEK |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q02763 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. |