Anti-OGDH Polyclonal Antibody
| 英文名称 | Anti-OGDH Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AKGDH;E1k;OGDC |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:10-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 116kDa |
| Gene ID | 4967 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human OGDH |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human OGDH |
| Subcellular Locations | Mitochondrion matrix |
| Swiss Prot | Q02218 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |