Anti-CHAMP1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CHAMP1 Polyclonal Antibody

英文名称 Anti-CHAMP1 Polyclonal Antibody
宿主 Rabbit
别名 CAMP;CHAMP;MRD40;ZNF828;C13orf8
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:25-100.
交叉反应 Human Mouse
蛋白分子量 89kDa
Gene ID 283489
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human CHAMP1
性状 液体
Public Immunogen Range A synthetic peptide of human CHAMP1
Subcellular Locations Nucleus Cytoplasm
Swiss Prot Q96JM3
克隆类型 Polyclonal Antibody
背景资料 CHAMP1 (chromosome alignment maintaining phosphoprotein 1), also known as ZNF828 or C13orf8, is a 812 amino acid protein containing one C2H2-type zinc finger. CHAMP1 is required for the proper alignment of chromosomes during metaphase, undergoing CDK1-dependent phosphorylation at multiple sites during mitosis. The phosphorylation counteracts the negative chromosomal alignment regulation of the zinc-finger domain of CHAMP1. One region of CHAMP1, the FPE region, is responsible for spindle and kinetochore localization, which is essential for proper chromosome alignment. CHAMP1 interacts with MAD2L2, PGOZ, CBX1, CBX3 and CBX5, and may recruit CENPE and CENPF to the kinetochore. The CHAMP1 gene is located on chromosome 13 and is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat and chicken.