Anti-CAB39 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CAB39 Polyclonal Antibody

英文名称 Anti-CAB39 Polyclonal Antibody
宿主 Rabbit
别名 MO25;CGI-66
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Human Mouse
蛋白分子量 40kDa
Gene ID 51719
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human CAB39
性状 液体
Public Immunogen Range A synthetic peptide of human CAB39
Subcellular Locations Cytoplasm Nucleus
Swiss Prot Q9Y376
克隆类型 Polyclonal Antibody
背景资料 Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).