Anti-DTX3L Polyclonal Antibody
品牌:solarbio | 货号:K006729P
英文名称 |
Anti-DTX3L Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
BBAP |
应用 |
WB |
稀释比例 |
WB 1:200-1000. |
交叉反应 |
Human |
蛋白分子量 |
84kDa |
Gene ID |
151636 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human DTX3L |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human DTX3L |
Subcellular Locations |
Cytoplasm Endosome Lysosome Membrane Nucleus |
Swiss Prot |
Q8TDB6 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The Deltex family is responsible for influencing Notch signaling and may regulate transcription through interactions with specific transcription factors. Deltex proteins have a basic N-terminus, a central proline-rich region and a C-terminal RING-type zinc finger domain, a motif often found in ubiquitin-protein isopeptide ligases (E3). The RING-type zinc finger domain binds two Zn2+ atoms and forms a cross-brace motif that is essential for many proteins involved the ubiquitination pathway. DTX3L (Deltex-3-like), also known as BBAP, is a 740 amino acid protein that is similar to Deltex-3 and acts as a ubiquitin ligase in vitro. DTX3L can heterodimerize with Deltex-1, a transcriptional regulator, thereby enhancing the activity of the E3 ubiquitin ligase complex and increasing the influence of E3 on the Notch signaling pathway. |