Anti-NPR1 Polyclonal Antibody
品牌：solarbio | 货号：K007384P
| 英文名称 | Anti-NPR1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ANPa;NPRA;ANPRA;GUC2A;GUCY2A |
| 应用 | IHC |
| 稀释比例 | IHC 1:25-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 119kDa |
| Gene ID | 4881 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human NPR1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human NPR1 |
| Subcellular Locations | Nucleus |
| Swiss Prot | P16066 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms . The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively). |