Anti-NFKB p65 Monoclonal Antibody-一抗-抗体-蛋白与免疫

Anti-NFKB p65 Monoclonal Antibody

品牌:solarbio | 货号:K200045M

英文名称 Anti-NFKB p65 Monoclonal Antibody
宿主 Mouse
别名 MGC131774;NFKB 3;NFKB3;TF65_HUMAN
应用 WB IHC IP
稀释比例 WB 1:1000-3000. IP 1:100-300. IF 1:100-200. IHC 1:200-500.
交叉反应 Human Mouse Rat
蛋白分子量 65kDa
Gene ID 5970
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG1
免疫原 recombinant protein
性状 液体
Public Immunogen Range recombinant protein
Subcellular Locations Cytoplasm Nucleus
Swiss Prot Q04206
克隆号 5G6
克隆类型 Monoclonal Antibody
背景资料 NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.