Anti-EGFR Monoclonal Antibody-一抗-抗体-蛋白与免疫

Anti-EGFR Monoclonal Antibody

品牌:solarbio | 货号:K200028M

英文名称 Anti-EGFR Monoclonal Antibody
宿主 Mouse
别名 Epidermal growth factor receptor;erbb 1;Receptor tyrosine protein kinase ErbB 1
应用 WB IP IF IHC
稀释比例 WB 1:1000-3000. IP 1:100-300. IF 1:100-200.
交叉反应 Human
蛋白分子量 170kDa
Gene ID 1956
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG1
免疫原 A synthetic peptide coupled to KLH
性状 液体
Public Immunogen Range A synthetic peptide coupled to KLH
Subcellular Locations Secreted Cell membrane
Swiss Prot P00533
克隆号 M6
克隆类型 Monoclonal Antibody
背景资料 The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades.