Anti-EGFR Monoclonal Antibody
品牌：solarbio | 货号：K200028M
| 英文名称 | Anti-EGFR Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 别名 | Epidermal growth factor receptor;erbb 1;Receptor tyrosine protein kinase ErbB 1 |
| 应用 | WB IP IF IHC |
| 稀释比例 | WB 1:1000-3000. IP 1:100-300. IF 1:100-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 170kDa |
| Gene ID | 1956 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG1 |
| 免疫原 | A synthetic peptide coupled to KLH |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide coupled to KLH |
| Subcellular Locations | Secreted Cell membrane |
| Swiss Prot | P00533 |
| 克隆号 | M6 |
| 克隆类型 | Monoclonal Antibody |
| 背景资料 | The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. |