Anti-NLRP3 Polyclonal Antibody
品牌：solarbio | 货号：K008087P
| 英文名称 | Anti-NLRP3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AII;AVP;FCU;MWS;FCAS;CIAS1;NALP3;C1orf7;CLR1.1;PYPAF1;AGTAVPRL |
| 应用 | WB |
| 稀释比例 | WB 1:200-1000. |
| 交叉反应 | Human |
| 蛋白分子量 | 118kDa |
| Gene ID | 114548 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human NLRP3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human NLRP3 |
| Swiss Prot | Q96P20 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5′ UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5′ UTR splice patterns are biologically valid. |