Anti-DROSHA Polyclonal Antibody
品牌：solarbio | 货号：K005767P
| 英文名称 | Anti-DROSHA Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ETOHI2;HSA242976;RANSE3L;RN3;RNASE3L;RNASEN |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 159kDa |
| Gene ID | 29102 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human DROSHA |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human DROSHA |
| Subcellular Locations | Nucleus nucleolus |
| Swiss Prot | Q9NRR4 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. |