Anti-PRKAB1 Polyclonal Antibody
品牌：solarbio | 货号：K106998P
| 英文名称 | Anti-PRKAB1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AMPK;AMPK beta 1;AMPK subunit beta 1;AMPKb;HAMPKb;PRKAB1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:8000-12000. IHC 1:100-300. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 33kDa |
| Gene ID | 5564 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PRKAB1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PRKAB1 |
| Subcellular Locations | Nucleus Cytoplasm? |
| Swiss Prot | Q9Y478 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. |