Anti-TRAIL Polyclonal Antibody
品牌：solarbio | 货号：K106468P
| 英文名称 | Anti-TRAIL Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | Apo-2L;APO2L;CD253;TL2;TNLG6A; |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 42kDa |
| Gene ID | 8743 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human TRAIL |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human TRAIL |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P50591 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |