Anti-PDX1 Polyclonal Antibody
品牌:solarbio | 货号:K106453P
英文名称 |
Anti-PDX1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
GSF;IDX-1;IPF1;IUF1;MODY4;PAGEN1;PDX-1;STF-1 |
应用 |
WB IHC |
稀释比例 |
WB 1:2000-5000.IHC 1:50-200. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
48kDa |
Gene ID |
3651 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human PDX1 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human PDX1 |
Subcellular Locations |
Cytoplasm Nucleus cytosol |
Swiss Prot |
P52945 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5′-[CT]TAAT[TG]-3′. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |