Anti-CD8 Polyclonal Antibody
品牌:solarbio | 货号:K106402P
英文名称 |
Anti-CD8 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
CD8A;MAL;Leu2;p32;OKT8 T cell antigen |
应用 |
WB |
稀释比例 |
WB 1:3000. |
交叉反应 |
Mouse |
蛋白分子量 |
28kDa |
Gene ID |
925 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human CD8 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human CD8 |
Subcellular Locations |
Cell membrane |
Swiss Prot |
P01732 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. |