Anti-CD8 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CD8 Polyclonal Antibody

品牌:solarbio | 货号:K106402P

英文名称 Anti-CD8 Polyclonal Antibody
宿主 Rabbit
别名 CD8A;MAL;Leu2;p32;OKT8 T cell antigen
应用 WB
稀释比例 WB 1:3000.
交叉反应 Mouse
蛋白分子量 28kDa
Gene ID 925
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human CD8
性状 液体
Public Immunogen Range A synthetic peptide of human CD8
Subcellular Locations Cell membrane
Swiss Prot P01732
克隆类型 Polyclonal Antibody
背景资料 Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.