Anti-CASP9 Polyclonal Antibody
品牌:solarbio | 货号:K101548P
英文名称 |
Anti-CASP9 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
APAF-3;APAF3;ICE-LAP6;MCH6;PPP1R56 |
应用 |
IHC |
稀释比例 |
IHC 1:50-200. |
交叉反应 |
Mouse |
蛋白分子量 |
46kDa |
Gene ID |
842 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human CASP9 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human CASP9 |
Subcellular Locations |
Cytosol Nucleus |
Swiss Prot |
P55211 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. |