Anti-TAK1 Monoclonal Antibody
品牌:solarbio | 货号:K006605M
英文名称 |
Anti-TAK1 Monoclonal Antibody |
宿主 |
Mouse |
别名 |
CSCF;FMD2;TAK1;MEKK7;TGF1a |
应用 |
WB |
稀释比例 |
WB 1:1000. |
交叉反应 |
Human Mouse Rat Monkey |
蛋白分子量 |
67/78kDa |
Gene ID |
6885 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG2b |
免疫原 |
Recombinant protein of human TAK1 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human TAK1 |
Subcellular Locations |
Cell membrane Cytoplasm Membrane |
Swiss Prot |
O43318 |
克隆类型 |
Monoclonal Antibody |
背景资料 |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6 various cytokines including interleukin-1 (IL-1) transforming growth factor-beta (TGFB) TGFB-related factors like BMP2 and BMP4 toll-like receptors (TLR) tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1 MAP2K3/MKK3 MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling plays a major role in the activation of MAPK8/JNK1 but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. |