Anti-ROCK1 Polyclonal Antibody
品牌：solarbio | 货号：K006828P
| 英文名称 | Anti-ROCK1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ROCK-I;P160ROCK |
| 应用 | IHC |
| 稀释比例 | IHC 1:25-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 158kDa |
| Gene ID | 6093 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ROCK1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ROCK1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q13464 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. |