Anti-CD45 Monoclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CD45 Monoclonal Antibody

品牌:solarbio | 货号:K200020M

英文名称 Anti-CD45 Monoclonal Antibody
宿主 Mouse
别名 GP180;L CA;CD45 antigen
应用 WB IHC
稀释比例 WB 1:1000-3000. IHC 1:100-300.
交叉反应 Human
蛋白分子量 147kDa
Gene ID 5788
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG1
免疫原 A synthetic peptide coupled to KLH
性状 液体
Public Immunogen Range A synthetic peptide coupled to KLH
Subcellular Locations Membrane Membrane raft
Swiss Prot P08575
克隆号 12A9
克隆类型 Monoclonal Antibody
背景资料 CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45.