Anti-CD59 Polyclonal Antibody
品牌:solarbio | 货号:K107053P
英文名称 |
Anti-CD59 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
16.3A5,1F5,EJ16,EJ30,EL32,G344,HRF-20,HRF20,MAC-IP,MACIF,MEM43,MIC11,MIN1,MIN2,MIN3,MIRL,MSK21,p18-20,CD59 glycoprotein |
应用 |
WB |
稀释比例 |
WB 1:5000-8000. |
交叉反应 |
Human |
蛋白分子量 |
14kDa |
Gene ID |
966 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human CD59 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human CD59 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
P13987 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. |