Anti-CD59 Polyclonal Antibody
品牌：solarbio | 货号：K107053P
| 英文名称 | Anti-CD59 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | 16.3A5,1F5,EJ16,EJ30,EL32,G344,HRF-20,HRF20,MAC-IP,MACIF,MEM43,MIC11,MIN1,MIN2,MIN3,MIRL,MSK21,p18-20,CD59 glycoprotein |
| 应用 | WB |
| 稀释比例 | WB 1:5000-8000. |
| 交叉反应 | Human |
| 蛋白分子量 | 14kDa |
| Gene ID | 966 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CD59 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CD59 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P13987 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. |