Anti-MBP Monoclonal Antibody
品牌：solarbio | 货号：K006383M
| 英文名称 | Anti-MBP Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 别名 | MBP |
| 应用 | WB IHC ICC FCM |
| 稀释比例 | WB 1:500-2000. IHC 1:200-1000. ICC 1:200-1000. FCM 1:200-400. |
| 交叉反应 | Human |
| 蛋白分子量 | 33kDa |
| Gene ID | 4155 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG1 |
| 免疫原 | Recombinant protein of human MBP |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human MBP |
| Subcellular Locations | Cell membrane Membrane Nucleus |
| Swiss Prot | P02686 |
| 克隆类型 | Monoclonal Antibody |
| 背景资料 | The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called “Golli-MBP”) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. |