Anti-GCR Polyclonal Antibody
品牌：solarbio | 货号：K101529P
| 英文名称 | Anti-GCR Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GCCR;GCR;GCRST;GR;GRL |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Human |
| 蛋白分子量 | 86kDa |
| Gene ID | 2908 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human GCR |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human GCR |
| Subcellular Locations | Cytoplasm Mitochondrion Nucleus Nucleus |
| Swiss Prot | P04150 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5′ UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. |